Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 116 for “"Molecular imaging"”.
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Molecular imaging with engineered physiology
Using molecular imaging in vivo, biomolecular and cellular phenomena can be investigated within their relevant physiological context, addressing a central challenge for 21st century biomedicine and basic research. To advance neuroscience in particular, molecular-level measurements across the brain …
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Towards brain-wide noninvasive molecular imaging
… underlies brain activity, yet studying these molecular events in living whole organisms remains a challenge. Magnetic resonance imaging (MRI) is the most promising imaging modality for development of molecular signaling sensors with deeper tissue penetration than optical imaging, and better …
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Absolute Quantitation for MR Molecular Imaging of Angiogenesis
<p>Medical imaging is undergoing a transition from an art that is used to make static images of human physiology into a scientific tool that employs advanced techniques to measure clinically relevant data. Recently, the role of magnetic resonance imaging in cardiovascular and oncological research …
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Molecular imaging of gene transduction in cardiac transplantation
… was established with the use of SPECT imaging. Following gene transfer, the recipients were injected with ⁹⁹mTc in the first set of experiments (Chapter 3) or with radioactive ¹²³I (Chapter 4) and imaged under a SPECT scanner. Radioactive isotope uptake in the Ad-NIS group was …
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Novel molecular imaging of cardiovascular disease in man
… of abdominal aortic aneurysms. Conventional imaging modalities have consistently failed to identify atherosclerotic plaques or aneurysms with high-risk pathological features that are at highest risk of rupture or progression. The development of modern molecular imaging techniques targeted at …
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Single quantum dot tracking for quantitative molecular imaging
… biomolecules. However, QD single-molecule imaging studies have almost been exclusively limited to the extracellular space, due to limitations in intracellular delivery techniques and a limited understanding of how nanoparticles behave in the intracellular space. In the first half of this …
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Engineering nanomaterials for molecular imaging and targeted therapy
… variety of applications in biology including bioimaging and drug delivery. Despite tremendous progress, applications of these materials for disease detection and treatment are restricted by several limitations such as lack of a multiplexed platform for molecular imaging and low targeting …
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New MRI Techniques for Nanoparticle Based Functional and Molecular Imaging
… use for several decades, magnetic resonance imaging: MRI) is undergoing a transition from a qualitative anatomical imaging tool to a quantitative technique for evaluating myriad diseases. Furthermore, MRI has made great strides as a potential tool for molecular imaging of cellular and tissue …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
The causes underlying the extent and character of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of individual patients. Tumors are complex and organized tissues that include …
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Genetically engineered sensors for non-invasive molecular imaging using MRI
… advance science and medicine. Magnetic resonance imaging (MRI) is a tool uniquely suited to this task because of its ability to image deep inside tissues at relatively high spatial and temporal resolution. However, the range of molecular phenomena currently accessible to MRI is limited by a lack …
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Developing osteoarthritis treatments through cartilage tissue engineering and molecular imaging
… native cartilage tissue. Biochemical assays and imaging techniques can be used to study some of the main components of cartilage and assess the value of potential therapies. Agarose and self-assembling peptides have been used to make hydrogels for in vitro culture of bovine bone marrow stromal …
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Development of Quantitative Ultrasound-Mediated Molecular Imaging of The Tumor Microenvironment
<p>While conventional diagnostic imaging modalities provide anatomical information to clinicians, these techniques are not sensitive to critical physiological processes. In order to properly classify cancer, it is necessary to investigate noninvasive methods which can provide insight into these …
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Development of small molecule probes for fluorescence and photoacoustic molecular imaging
Molecular imaging enables the visualization, characterization and quantification of biochemical processes taking place at the molecular levels within intact living subjects. As such, it has become an indispensable tool for both basic research and biomedical applications. In particular, fluorescence …
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Development and Evaluation of Approaches for Quantitative Optical Molecular Imaging of Neoplasia
… and evaluates three approaches for quantitative molecularly-targeted optical imaging of neoplasia. The first approach focuses on widefield imaging of biomarkers near the tissue surface for early detection applications; this approach is demonstrated in freshly resected oral tissue. Most oral …
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Molecular imaging of calcification and inflammation in aortic valve disease and atherosclerosis
… is able to demonstrate both anatomy (CT) and molecular processes (PET) in vivo. The 18F-sodium fluoride (18F-fluoride) isotope has shown promise in early cardiovascular studies. The purpose of this thesis was to elucidate the mechanisms of cardiovascular 18Ffluoride uptake and define how …
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Engineering Microbubbles with the Buried-Ligand Architecture for Targeted Ultrasound Molecular Imaging
… they are being developed for targeted diagnostic molecular imaging applications. Previous studies have shown that targeted microbubbles could induce complement activation and reduce their circulation persistence. In order to avoid the undesired immune response, a novel stealth microbubble design …
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Molecular imaging with mass spectrometry: instrumental and methodological advances for biological applications
Mass spectrometry imaging (MSI) is an analytical technique providing a unique combination of capabilities: label-free, non-targeted, and highly multiplex detection and imaging of chemical species ranging in mass from single protons to large proteins exceeding 100 kDa, identifiable by mass and …
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High-resolution multi-parametric molecular imaging via multi-dimensional MR spectroscopic imaging
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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