Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Molecular functions"”.
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Developmental and Molecular Functions of Plakophilin-3
… the desmosomal plaque, little is known about its functions in the cytoplasm or nucleus, where it also localizes.</p> <p>My work employed embryos of the amphibian, <em>Xenopus laevis</em>, to examine plakophilin-3’s developmental roles. I first evaluated the expression pattern of endogenous …
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Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3
<p>Mixed Lineage Leukemia protein (MLL) is required for proper embryonic development, and hematopoiesis. It is a SET domain containing histone methyl transferase that trimethylates histone H3 on lysine 4 (H3K4Me3), a histone modification that correlates with active transcription. The 3rd PHD finger …
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Genetic requirements and molecular functions of 5-methylcytosine in Caenorhabditis elegans RNA
… feature in biological systems. Yet, the molecular functions of this modification, as well as the mechanisms through which this mark is interpreted are still poorly understood. In this thesis, I used Caenorhabditis elegans as a model organism for the study of genes and molecular functions …
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The early history and emergence of molecular functions and modular scale-free network behavior
… structural domains requires that biochemical functions, defined by conserved amino acid sequence motifs, be embedded into a structural scaffold. Here we trace domain history onto a bipartite network of elementary functional loop (EFL) sequences and domain structures defined at the fold …
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Characterization of molecular functions of polyamines in fruit development and ripening in tomato (Solanum lycopersicum)
… senescence, and stress responses. To elucidate molecular roles of PAs in fruit development and ripening, I characterized transgenic tomato plants ectopically expressing yeast spermidine synthase (ySpdSyn) or S-adenosylmethionine decarboxylase (ySAMdc) under constitutive CaMV 35S and/or …
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Characterization of molecular functions of polyamines in fruit development and ripening in tomato (Solanum lycopersicum)
… senescence, and stress responses. To elucidate molecular roles of PAs in fruit development and ripening, I characterized transgenic tomato plants ectopically expressing yeast spermidine synthase (ySpdSyn) or S-adenosylmethionine decarboxylase (ySAMdc) under constitutive CaMV 35S and/or …
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Leveraging knowledge networks for precision medicine
… pharmacological, and interactomic data. Other molecular data, including expression profiles, genomic mutations and cell conditions, have also been massively generated and they are further refining our understanding of disease mechanisms. In addition, patient data, gathered by electronic medical …
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Effects of somatic cell nuclear transfer on transcripts related to IGF signaling, EGF signaling and cell adhesion during the peri-implantation period in cattle
… knowledge on temporal regulation of these molecular functions during the peri-implantation period in cattle. On the basis of functional ontology enrichment analysis, integrin signaling, IGF1R signaling, EGFR/ERBB signaling, and PI3K/AKT and ERK1/2 signaling, two signal transduction pathways …
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Foundation Models for Protein Phenotype Prediction
… 20% of human proteins lacking known functions and more than 40% missing context-specific functional insights. Even well-annotated proteins are often poorly characterized in diverse biological contexts, disease states, and perturbations. We present ProCyon, a foundation model for …
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Development of Bioluminescent Biosensors Monitoring Activity of the Merlin Tumour Suppressor
… activity in real time. First, we design an intramolecular biosensor aimed at studying Merlin’s changes in conformation state. In addition, we design a bimolecular split-luciferase system to investigate Merlin’s regulation of the Hippo pathway, a key downstream effector with well-established roles …
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Cloning, Characterization, and Functional Study of Laminin a Chain in Hydra
… used in this study of extracellular matrix (ECM) molecular functions at the genetic level. To clone ECM genes, screening of a hydra cDNA library was accomplished by using a laminin A chain sequence obtained from polymerase chain reaction as a probe. A clone, 1am A1, was sequenced and characterized …
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Specific Roles of Kal-1 in Olfaction: A Model of Kallmann Syndrome in Drosophila
… little is known about the cellular processes and molecular functions underlying KS. Here, I isolated a Drosophila kal-1 null mutant, which removes the entire kal-1 coding region. Antibody staining shows that Anosmin-1 specifically localizes to the dendrites of olfactory receptor neurons (ORNs) …
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… gene. To understand the cellular and molecular processes associated with its role in disease, we generated multiple mouse models with targeted depletion of MED12 in distinct cellular lineages. Our genetically engineered models with induced and conditional deletion of Med12 …
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Investigating the effect of paralogs on microarray gene-set analysis
… have high sequence identity and similar molecular functions also exhibit high correlation in their expression patterns. This, together with the fact that the calculation of gene-set significance by all GSA methods is influenced by the number of genes in the gene set, means that sets with …
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Discovery and engineering of antiviral defense systems in bacteria and archaea
… and archaea have acquired a potent arsenal of molecular defense systems in order to survive. Known defense systems, such as CRISPR, have given rise to transformative technologies including genome editing. However, defense systems as a whole remain underexplored. Continued investigation of these …
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Functional analysis of low grade glioma genetic variants using statistics and physics-inspired deep learning methods
… least 25 risk loci have been identified, whose molecular functions, however, remain largely unknown. Understanding how the risk loci function in tumorigenesis poses a major challenge in the field, owing to potential confounding factors and the lack of relevant types of experimental data in the …
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Analysis of Interrelationships Among NAD+, PARP1, ADP-Ribosylation, and Splicing in Murine Embryonic Stem Cells
… and lineage commitment. Given the diverse molecular functions of PARP1, I sought to determine the potential regulatory role of PARP1 in determining ESC state. PARP1 functions both as an enzyme, through its NAD+-dependent ADP-ribosyltransferase catalytic activity, and as a structural …
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Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
… the developing and adult brain predict important functions in neural circuits mediating vocalization and sensorimotor learning. Their known gene targets regulate neuronal development, activity, and plasticity, and animal models of FoxP2 and FoxP1 function have linked some of these molecular …
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Molecular genetics of abdominal aortic aneurysm
… Genes were then classified according to their molecular functions. A set of consistently differentially expressed genes were confirmed using qRT-PCR with Taqman probes on a larger sample size compared with the microarray experiment. All pathway and network analysis on the differentially …
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