Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Molecular factors"”.
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Improving Mixture Cure Modelling of Multiple Molecular Factors in Cancer Prognosis
… strategy to incompletely measured prognostic factors.
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MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS
… two hypotheses put forward to explain the molecular mechanisms responsible for this. Additionally, guanine nucleotides competitively inhibit AMPA receptors and a second goal has been to further characterize guanine nucleotide binding, and to create mutations that selectively diminish this …
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Investigating genetic and molecular factors contributing to sexual dimorphism in lung disease
… sex and disease, the contributory genetic and molecular factors remain poorly understood. Preliminary analysis of patient-derived primary airway cells identified that female-derived cells produce increased levels of the proinflammatory cytokine IL6 compared to male cells, irrespective of …
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Genetic and molecular factors regulating growth and morphology in Senegalese sole (Solea senegalensis)
… are complex trait regulated by genetic factors, phenotypic plasticity, and other life cycle aspects, such as reproduction. This thesis aims to explore the phenotypic and genetic factors controlling morphology and growth in Senegalese sole (Solea senegalensis) through an integrative …
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Biochemical Analysis of the Molecular Factors of Leucyl -Trna Synthetase That Ensure Aminoacylation Fidelity
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
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Biochemical Analysis of the Molecular Factors of Leucyl-Trna Synthetase That Ensure Aminoacylation Fidelity
The tRNA synthetases catalyze aminoacylation of transfer RNA (tRNA) with specific amino acids. Accurate aminoacylation is critical to the fidelity of protein synthesis. Leucyl-tRNA synthetase (LeuRS) can misactivate a broad scope of non-leucine amino acids. In these cases, mischarged tRNA products …
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On the Origin of Phenotypic Variation: Novel Technologies to Dissect Molecular Determinants of Phenotype
… techniques applied to the dissection of molecular factors underlying phenotypic variation. The first part of my work is focused on finding rare genetic variants in pooled DNA samples, leading to the development of a novel set of algorithms, SNPseeker and SPLINTER, applied to …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
… class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a panel of 17 gastric cancer cell lines with multiple …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
… a long-lived protein, it contains an intrinsic molecular clock, deamidation, that accumulates over time. Misfolding and aggregation of SOD1 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and, more recently, Parkinson's disease. To investigate the …
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The Influence of Quercetin, Curcumin, and Resistance Exercise On Anabolic Signaling In the Skeletal Muscle of Cachectic Mice
… been shown to indirectly or directly influence molecular factors involved in increasing net protein synthesis. Thus the purpose of this study was to examine if quercetin or curcumin supplementation, with or without the combination of resistance exercise, could blunt muscle mass loss in colon and …
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Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
… in time and in space. However, the genetic and molecular factors underlying these behaviors are difficult to study in their native contexts and, as a result, are often not well understood. Although next-generation sequencing and image-based methods have enabled high-throughput profiling of cell …
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A Free Heme Perspective to Sickle Hemoglobin Polymerization
… in the sickle cell anemia. Many cellular and molecular factors have been identified so far as contributor towards the polymerization event. The free heme, prosthetic group of hemoglobin, is one such small molecule which has been previously shown to enhance the polymerization by orders of …
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The racial disparities of the Gamma-secretase/Notch pathway and inhibition in triple negative breast cancer
… This master's thesis aims to delve into the molecular intricacies that contribute to these disparities, with a specific focus on gamma secretase activity, a key regulator of cellular processes.</p> <p>The research methodology encompasses a multi-faceted approach, amalgamating clinical data …
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Investigation of the mechanism of transfer of a-tocopherol by the human a-tocopherol transfer protein (H-a-TTP) /
… membranes by a-TTP, is still unclear and the molecular factors influencing transfer remain elusive. To investigate the mechanism of ligand transfer by the h-a-TTP, a fluorescent analogue of a-toc has been used in the development of a fluorescence resonance energy transfer (FRET) assay. …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… the current dissertation was to define intrinsic molecular mechanisms that govern these skeletal muscle capillary remodelling responses in obesity. Administration of a 16-week high-fat (HF) diet was associated with and expansion (angiogenesis) of the skeletal muscle capillary network and promoted …
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Deciphering Underlying Mechanisms Of Photoreceptor Outer Segment Degradation; Involvement Of Intracellular Trafficking
… diseases it is important to uncover the molecular factors that are involved in the phagocytic activity of RPE uptake and clearance of POS. Lack of molecular methods and assays have limited our knowledge of these factors. In this project I developed a novel method which is used to uncover …
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Enhancing Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering
… to compare these two cells types and a set of molecular factors were identified as mis-expressed during MSC chondrogenesis. Although work up to this point focused on optimizing compressive properties, the tensile properties of articular cartilage are also critical to its functional role. In …
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Maximum Entropy Optimization: a General Approach to Study Ordered and Disordered Proteins Reveals Key Features of Protein Phase Separation
… regulation and signal sensing. The molecular factors that dictate these condensates' stability and spatial organization are not fully understood, and it remains challenging to predict their microstructures. Computational modeling could provide high-resolution structural …
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Mechanistic studies of ion binding and inactivation in the potassium channel KcsA by solid state NMR
… The results have led to insights into the molecular factors that stabilize the collapsed or inactivated state of the channel, and firmly establish KcsA as a model membrane protein system for future studies of structure and dynamics by solid state NMR.
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