Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Molecular factors"”.
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Molecular factors influencing epithelial-mesenchymal transition in breast cancer
Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. In a cell model …
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Improving Mixture Cure Modelling of Multiple Molecular Factors in Cancer Prognosis
… strategy to incompletely measured prognostic factors.
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MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS
… two hypotheses put forward to explain the molecular mechanisms responsible for this. Additionally, guanine nucleotides competitively inhibit AMPA receptors and a second goal has been to further characterize guanine nucleotide binding, and to create mutations that selectively diminish this …
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Investigating genetic and molecular factors contributing to sexual dimorphism in lung disease
… sex and disease, the contributory genetic and molecular factors remain poorly understood. Preliminary analysis of patient-derived primary airway cells identified that female-derived cells produce increased levels of the proinflammatory cytokine IL6 compared to male cells, irrespective of …
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Genetic and molecular factors regulating growth and morphology in Senegalese sole (Solea senegalensis)
… are complex trait regulated by genetic factors, phenotypic plasticity, and other life cycle aspects, such as reproduction. This thesis aims to explore the phenotypic and genetic factors controlling morphology and growth in Senegalese sole (Solea senegalensis) through an integrative …
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Biochemical Analysis of the Molecular Factors of Leucyl -Trna Synthetase That Ensure Aminoacylation Fidelity
Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.
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Biochemical Analysis of the Molecular Factors of Leucyl-Trna Synthetase That Ensure Aminoacylation Fidelity
The tRNA synthetases catalyze aminoacylation of transfer RNA (tRNA) with specific amino acids. Accurate aminoacylation is critical to the fidelity of protein synthesis. Leucyl-tRNA synthetase (LeuRS) can misactivate a broad scope of non-leucine amino acids. In these cases, mischarged tRNA products …
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On the Origin of Phenotypic Variation: Novel Technologies to Dissect Molecular Determinants of Phenotype
… techniques applied to the dissection of molecular factors underlying phenotypic variation. The first part of my work is focused on finding rare genetic variants in pooled DNA samples, leading to the development of a novel set of algorithms, SNPseeker and SPLINTER, applied to …
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Differential neurogenesis in the adult rat dentate gyrus
… region contains several critical cell types and molecular factors that are known to be critical to the neurogenic niche, including stem cells. We also present data that attempt to conceptualize the existence of this region in the context of early agerelated declines in neurogenesis. Finally, we …
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Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells
… class of anticancer epigenetic drugs, however, molecular factors influencing the responses of individual tumors to HDACi therapies remain obscure. Here, we sought to identify genes associated with HDACi resistance in gastric cancer. Treating a panel of 17 gastric cancer cell lines with multiple …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
… a long-lived protein, it contains an intrinsic molecular clock, deamidation, that accumulates over time. Misfolding and aggregation of SOD1 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and, more recently, Parkinson's disease. To investigate the …
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The Influence of Quercetin, Curcumin, and Resistance Exercise On Anabolic Signaling In the Skeletal Muscle of Cachectic Mice
… been shown to indirectly or directly influence molecular factors involved in increasing net protein synthesis. Thus the purpose of this study was to examine if quercetin or curcumin supplementation, with or without the combination of resistance exercise, could blunt muscle mass loss in colon and …
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Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
… in time and in space. However, the genetic and molecular factors underlying these behaviors are difficult to study in their native contexts and, as a result, are often not well understood. Although next-generation sequencing and image-based methods have enabled high-throughput profiling of cell …
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Effect of 2,4-dichlorophenol on biological model membranes
The aim of this work was to examine molecular factors and processes with respect to the uptake, distribution and effects of chlorophenol derivatives inside the cell membrane of microorganisms, particularly in the phospholipid bilayer matrix. 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) …
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A Free Heme Perspective to Sickle Hemoglobin Polymerization
… in the sickle cell anemia. Many cellular and molecular factors have been identified so far as contributor towards the polymerization event. The free heme, prosthetic group of hemoglobin, is one such small molecule which has been previously shown to enhance the polymerization by orders of …
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The racial disparities of the Gamma-secretase/Notch pathway and inhibition in triple negative breast cancer
… This master's thesis aims to delve into the molecular intricacies that contribute to these disparities, with a specific focus on gamma secretase activity, a key regulator of cellular processes.</p> <p>The research methodology encompasses a multi-faceted approach, amalgamating clinical data …
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Einfluss eines kontrollierten Zinkmangels auf die Proteinexpression im Heilungsprozess intestinaler Anastomosen der Ratte
… and experience of the surgeon influences of molecular factors are considered to be important for a successful wound healing. The change of the extracellular matrix is one of the-se factors. Prevention of disturbances of wound healing requires a fundamental knowledge of molecular processes. …
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Investigation of the mechanism of transfer of a-tocopherol by the human a-tocopherol transfer protein (H-a-TTP) /
… membranes by a-TTP, is still unclear and the molecular factors influencing transfer remain elusive. To investigate the mechanism of ligand transfer by the h-a-TTP, a fluorescent analogue of a-toc has been used in the development of a fluorescence resonance energy transfer (FRET) assay. …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… the current dissertation was to define intrinsic molecular mechanisms that govern these skeletal muscle capillary remodelling responses in obesity. Administration of a 16-week high-fat (HF) diet was associated with and expansion (angiogenesis) of the skeletal muscle capillary network and promoted …
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