Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Molecular epidemiology"”.
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Molecular Epidemiology of Breast Cancer
Hereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously …
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The molecular epidemiology of bluetongue virus in northern Colorado
… based on adequate scientific knowledge of the epidemiology of the disease. Studies in this dissertation were guided by the hypothesis that BTV overwinters in its arthropod vector, Culicoides sonorensis. The overwintering mechanism of BTV was investigated using a variety of traditional virologic …
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Molecular epidemiology of West Nile virus in North America
… changes in WNV and to illustrate novel molecular mechanisms of attenuation of WNV. The results from these aims demonstrate that as WNV has accumulated mutations in its genome, phenotypic variants have emerged with significantly different biological properties when compared to progenitor …
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Molecular epidemiology of rabies in Kwazulu-Natal, South Africa
… order to contribute to the understanding of the molecular epidemiology of rabies in the KwaZulu Natal province, and to thereby assist in future surveillance and control efforts, we conducted a molecular sequence analysis of representative panel of viral isolates which were obtained from the …
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The Molecular Epidemiology of West Nile Virus in North America
West Nile virus (WNV) was introduced into North America in 1999. The original genotype of WNV in North America, NY99, was displaced in 2002 with the current dominant genotype, NA/WN02, which was first identified in 2002. This genotype is characterized by 13 nucleotide changes encoding for one amino …
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A study of norovirus: molecular epidemiology, pathogenesis and antiviral development
… The first aim of this thesis was to study the molecular epidemiology of NoV in the Asia Pacific region including; Singapore, Australia and New Zealand. In this study, three comprehensive molecular epidemiological studies were performed to characterise NoV strains circulating in Singapore (2004 …
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Molecular Epidemiology and Evolution of Corynebacterium diphtheriae and Vibrio cholerae
Molecular Epidemiology and Evolution of Corynebacterium diphtheriae and Vibrio cholerae Robert C. Will The infectious diseases diphtheria and cholera affect thousands of people around the world every year, and are caused by the bacterial species Corynebacterium diphtheriae and Vibrio cholerae …
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The molecular epidemiology of Salmonella Typhi and applications for policy
… I conducted phylogenetic analyses of the first molecularly confirmed azithromycin-resistant S. Typhi isolated in Pakistan and India and put them into context with contemporaneous azithromycin-resistant isolates. I found that single point mutations in acrB (efflux pump) were emerging …
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The Molecular Epidemiology of Enteric Fever in South and Southeast Asia
… the burden of this disease. Understanding the epidemiology of typhoid fever in different endemic settings as well as the impact of AMR on the disease outcome is crucial for disease control and management. <br></br><br></br> First, this thesis utilized whole genome sequences of <i>S.</i> Typhi …
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The Spatial and Molecular Epidemiology of Lyme Disease in Eastern Ontario
Lyme disease is an emerging tick-borne illness in Canada, with human case numbers increasing 15- to 20-fold since Lyme disease became nationally notifiable in 2009 until the present. In Ontario, Canada's largest province by population, average Lyme disease incidence across the province is similar …
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Molecular epidemiology of M. Tuberculosis transmission in the United Arab Emirates
… infection by atypical mycobacterium but further molecular biology work is needed to establish a clear conclusion. There was evidence of exogenous and endogenous strains infecting both the Emirati and non-Emirati population with no bias. The molecular technique was of limited discriminatory power …
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Ecology and molecular epidemiology of tick-borne infection in Kachia Grazing Reserve, Nigeria
… their economic importance, information on the epidemiology of these infections in many SSA countries, including Nigeria, is lacking or inadequate, resulting in potentially inappropriate disease control strategies being implemented. Therefore, the aim of this thesis was to investigate the …
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Molecular epidemiology of human rabies diagnosed in South Africa between 1983 and 2007
… after an animal exposure. The findings from the molecular epidemiology study reinforced the previous findings which correlate most human rabies cases with the coastal KwaZulu Natal canine cluster identified in previous studies. As humans are a dead end host to rabies infection, it was expected …
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Staphylococcus aureus and Staphylococcus pseudintermedius in animals: molecular epidemiology, antimicrobial resistance, virulence and zoonotic potential
Staphylococcus aureus es colonizador común de la piel y mucosas del hombre y otros animales y el perro es el hospedador habitual de S. pseudintermedius. Ambas especies son también importantes patógenos oportunistas. La epidemiología y ecología de estas especies bacterianas en animales ha cobrado …
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Molecular epidemiology of the multidrug-resistant Escherichia coli sequence type 131-H30 lineage among U.S. children
… addresses several knowledge gaps about the epidemiology and transmission dynamics of H30 among U.S. children through the integration of high-resolution molecular data from clinical extraintestinal E. coli isolates with patient epidemiologic data. I observed that although H30 is less common …
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Passive surveillance of STI pathogens in Cape Town, South Africa: A six-month molecular epidemiology study
… prevalence and to evaluate the potential of a molecular assay as a surveillance tool in our setting. Methods: Urogenital swabs, submitted to Groote Schuur Hospital over a period of 6 months, for routine microbiological investigations, were subjected to a commercial multiplex PCR assay to …
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Molecular epidemiology of trypanosomiasis in Ugandan cattle during the Stamping Out Sleeping Sickness control programme, 2006 – 2008
… the reservoir potential of these animals in the epidemiology of human disease. During 2006 a control programme was launched to halt the northward spread of this zoonotic parasite. This programme, entitled ‘Stamping Out Sleeping Sickness’ (SOS) proposed to reduce the prevalence of Human African …
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