Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Molecular complexity"”.
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DEVELOPING ENANTIOSELECTIVE CYCLOADDITIONS OF REDOX-ACTIVE-DERIVED REAGENTS: A LATENT STRATEGY TO ESTABLISH MOLECULAR COMPLEXITY
… functional groups, thereby establishing C(sp3)-complexity. Moreover, these methods represent a departure from traditional synthetic logic and offer promising avenues for enhancing the practical utility of asymmetric catalytic reactions in the synthesis of complex molecules.
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Chemical diversification of the natural products quinine, abietic acid and pleuromutilin by ring distortion
… molecules and can lead to striking changes in molecular structure. Strategic application of ring distortion reactions to complex molecules, such as natural products, is an effective method for the generation of compounds that exhibit significant molecular complexity, but possess vastly …
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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
… are desperately needed. Understanding the molecular pathways involved in CaP initiation, progression, and resistance to treatment may help identify novel therapeutic targets. However, the molecular complexity of individual CaP genomes along with the heterogeneity observed between patients …
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Characterisation of the role of Sox4 in mouse embryonic development
The molecular complexity of cardiogenesis is revealed by the high incidence of heart phenotypes resulting from mutation to any of a vast number of genes across multiple pathways. Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in …
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Cascade Approaches to Polycyclic Natural Products
… cascade chemistry to rapidly form high levels of molecular complexity and introduce elements of considerable difficulty, such as rigid fused-ring systems and quaternary chiral centers, has been applied to the chosen molecules. The results of these studies have demonstrated the power of …
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Diastereoselective nickel-catalyzed reductive coupling of alkynes and aldehydes and application towards the B-type amphidinolides
… were selected as ideal targets owing to their molecular complexity and the paucity of synthetically viable means for their total construction. The diastereoselective nickel-catalyzed reductive coupling of simple aryl-substituted alkynes and a-oxyaldehydes was developed and applied to the …
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Novel Photochemical Methodologies for Diversity Oriented Synthesis and Screening of Combinatorial Libraries
… This methodology offers a rapid increase in molecular complexity and diversity of the target scaffolds.</p> <p>To develop this novel methodology further and explore its generality, we directed our attention to the <em>Diels-Alder</em> adducts based on various chromones. We discovered that the …
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Advances in Selectivity of the Suzuki-Miyaura and Hofmann-Löffler-Freytag Reactions
… as a result of their ability to rapidly generate molecular complexity. Despite these advances, a chemist’s ability to judiciously, selectively, and predictably perform these synthetic transformations has not yet been fully realized. Herein disclosed are the investigations into new methods for the …
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On the stability of complex ions in ionic liquid Ion sources
… the stability of solvated ions depends on the molecular composition of the ionic liquid. Based on these results, it has been hypothesized that the stability of solvated ions increases with increasing molecular complexity of the ions. The focus of this work is to test this hypothesis by …
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Characterizing in vitro propagation and radiation response of murine mammary stem cells
… could explain the heterogeneity and molecular complexity of breast cancer. However, the involvement and the underlying mechanisms of such targets have yet to be fully elucidated. This study was designed to investigate mammary stem cells as plausible targets of radiation-induced damage …
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Synthetic Study Of Karlotoxins And Investigation Of Alpha-Diaminoboryl Carbanion Chemistry
… potent biological activities as well as novel molecular complexity engaged our interest in the synthesis of KmTx molecules in the purpose of supplying more samples for further biological evaluations. We have successfully established a synthetic route to access the C(40-61) B-ring fragment of …
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Towards a comprehensive human protein-protein interaction network
… Human genes create additional challenges due to molecular complexity, tissue specificity, and alternate splicing. It therefore becomes important to build well-annotated benchmarks and accuracy measures to evaluate new data. Here, we describe three methods that provide a framework to build a …
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Experimental investigations of molecules desorbing from a cold surface with buffer gas cooling and broadband roational spectroscopy : applications in astrochemistry
… it significant relevance in the context of molecular radioastronomy which continues to enrich our understanding of the molecular complexity in the interstellar medium. Furthermore, CPICE is geared to investigate the formation and quantification of complex organic molecules upon the slow …
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Discovery and Development of a Three-Component Oxidopyrylium Cycloaddition and Its Application Towards alpha-Hydroxytropolone Synthesis
… biology, and medicinal chemistry due to their molecular complexity and effects on physiological systems. The total synthesis of natural products has not only produced novel reaction methods and strategies capable of efficiently generating complex structural motifs but also granted access to …
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Rhodium-Catalyzed Asymmetric Ring Opening of Oxabicyclic Alkenes and Palladium-Catalyzed Carbon-Halogen Bond Forming Reactions
… in organic chemistry, since a great deal of molecular complexity can be generated from simple starting materials. Highly regio- and stereoselective processes have been made possible through the use of transition metal catalysts, alongside specialized ancillary ligands and in combination with …
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Transition Metal-Catalyzed Preparation and Functionalization of Nitrogen-Containing Heterocycles
… have paved the way to enable rapid increases in molecular complexity with far less effort than previously required. The active ingredient in traditional cross-coupling reactions is a catalytic quantity of palladium. Provided that the two reactants to be cross-coupled have the appropriate …
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Chemical Biology Tools to Study Bacterial Cell Surface Glycans
… in infections and pathogenesis. Understanding molecular determinants of these important biological functions is critical for both fundamental and translational research. Despite the need to better understand these important biological structures, methods for probing glycan structure and …
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Topology, Symmetry and Mechanics: Deciphering and Controlling information flows in a living cell
… on lengths that are tens of thousands the molecular size. During force-generating processes such as cell divisions, both the spatial and temporal aspects of protein patterning convey essential physiology outcomes. While many advances focusing on the molecular complexity of such …
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Understanding the evolution of the apical organ in the early branching metazoan, Nematostella vectensis
… apical domain of N. vectensis, uncovering the molecular complexity of this sensory organ.<br/>Comparative analyses of tissue-specific transcriptomes across other cnidarian species revealed a high level of conservation of anteroposterior patterning genes between N. vectensis and stony corals, …
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