Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Molecular classification"”.
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Molecular Classification of Bladder Cancer
… medicine, i.e. the exploitation of specific molecular properties in the treatment of tumors. The starting point for personalized medicine is a taxonomy of the tumor type, where genome, transcriptome, and/or proteome data is used to define molecular subtypes that make sense from biological and …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… features, their similarity and heterogeneity at molecular levels are not fully elaborated yet. Here, by performing comparative analysis of gene expression profiling of BCC, SCC, and normal skin tissues, we could classify the BCC into three subtypes of classical, SCC-like, and normal-like BCCs. …
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DEEP LEARNING ALGORITHM FOR MOLECULAR CLASSIFICATION OF ENDOMETRIAL CANCER FROM WHOLE SLIDE HISTOPATHOLOGY IMAGES
… cancer (EC) is a common malignancy whose molecular classification (POLEmut, MMRd, p53-abn, NSMP) guides prognosis and treatment. While MMRd and p53-abn can be assessed through IHC, POLEmut identification requires gene sequencing, which is costly and often unavailable. In this study, we …
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An integrative bioinformatics approach to characterize molecular landscapes and clinical outcomes in acute leukemias
… population-based disease patterns, RNA-seq-based molecular classification, and developmental interpretation. First, nationwide German cancer registry data were used to characterize acute leukemias. The analyses revealed age-dependent differences in incidence, treatment, and survival. Rare …
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Identifying tightly regulated and variably expressed networks by differential rank conservation (DIRAC)
… signal from noise in biology is to convert the molecular data from individual genes or proteins into an analysis of comparative biological network behaviors. One of the limitations of previous network analyses is that they do not take into account the combinatorial nature of gene interactions …
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Molecular Consequences of High Taz Expression In Gliomas
… a range of genetic and epigenetic alterations. Molecular classification of these tumors has identified different transcriptional subtypes, the most notable being Proneural (PN) and Mesenchymal (MES) classes. The most aggressive forms of the disease have a Mesenchymal expression signature, with …
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Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer
… employed to predict different mutational and molecular profiles in CRC. DGEA was also performed to determine the role of GREM1 expression in drug resistance. Hierarchical clustering was used throughout the course of this project using the Partek Genomics Suite software. Additionally, …
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Deconvolute Brain Tumor Genomic Alterations Based On Dna Methylation
<p>Molecular classification based on mutations, expression subtypes, and copy number variants has improved diagnosis and treatment decision-making for patients with brain tumors, particularly malignant gliomas. However, the association between epigenetic signature and genetic alterations is poorly …
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Classificazione su base molecolare dei tumori mammari della cagna mediante metodica immunoistochimica
Background. A new classification system of human breast tumours based on the immunohistochemical characterization has been applied to mammary tumours of the female dog with the aim to verify its association with invasion and grade, and prognostic aid in veterinary medicine. Methods. Forty-five …
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Elucidation of the occurrence of extracolonic cancers in Lynch syndrome
… dominant mode of inheritance. Determine the molecular pathology of extracolonic cancers in Lynch syndrome and to elucidate whether or not the occurrence of these extracolonic cancers are a direct result of the mismatch repair deficiency. First, a modifier study was performed assessing the …
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Hereditary diffuse leukoencephalopathy with spheroids: Insights into an adult onset neurodegenerative disease
… images, cerebrospinal fluid (CSF) biomarkers and molecular genetic data to place HDLS in a nosographic context and define its relationship with other neurodegenerative disorders. We updated the original Swedish HDLS family and created a pedigree consisting of 166 individuals. Fifteen of those …
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Studies on the Roles of PDGFRA and EGFR in the Classification and Identification of Therapeutic Targets for Human Gliomas
… nervous system (CNS). However, the current classification of gliomas is highly subjective and even inaccurate in some cases, which leads to clinical confusion and hinders the development of targeted therapies. EGFR and PDGFRA play crucial roles in glia development and glioma pathogenesis. In …
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Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer with Gene Expression and Computational Pathology
… different response to NAT. The published classification is based on RNA expression from fresh frozen tissue, which is impractical in a clinical setting. Initially, I attempted to build an accurate classifier for IntClusts based on RNA expression from widely available FFPE tissue, using a …
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Dimensionality Reduction, Feature Selection and Visualization of Biological Data
… and facilitate Muscular Dystrophy (MD) subtypes classification, we extract molecular features from MD microarray data by constructing sub-networks using a novel integrative scheme which utilizes protein-protein interaction (PPI) network, functional gene sets information and mRNA profiling data. …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
… as effective approaches for enhancing the molecular classification, diagnosis, prognosis or prediction of therapeutic response towards personalized therapy for cancer patients. Thanks to modern genome-wide profiling technology, scientists are able to build engines leveraging massive genomic …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… an unprecedented opportunity for dissecting molecular mechanisms in cancer biology. Here we present deep profiling of whole proteome, phosphoproteome and transcriptome in two high-grade glioma mouse models driven by mutated receptor tyrosine kinase (RTK) oncogenes, platelet-derived growth …