Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 118 for “"Molecular changes"”.
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Mapping Molecular Changes in Human Neuropsychiatric Disorders to Zebrafish Behavioral Profiles
… has remained elusive. Recent advances in molecular profiling have allowed researchers to probe genetic and transcriptomic differences in post-mortem samples from individuals with healthy and diseased brains, which has provided some hints into the underlying biological dysregulation in …
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Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation
… and therapeutic relevance to understand the molecular event, involved at different stages of oral cancer. Using a unique series of primary cultures from biopsies of normal oral mucosa, dysplasias and squamous cell carcinomas we have identified molecular changes characteristic of early oral …
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Histopathological and Molecular Changes in Intestinal Tissue Following Proton Exposure in Varying Mouse Models
… previously unknown and hopefully elucidate molecular insight into the early disease processes associated with irradiation. The significance of this study is provided in that the knowledge obtained here can be used to better select low dose radiation exposure limits, discover effective …
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The precision of initial context fear memory encoding determines the behavioural, cognitive and molecular changes that occur following recall
Maintaining memory relevance in the face of an ever-changing world is essential for survival. When animals form memories about specific environmental contexts and their associations, they must be able to continually assess the validity of both those associations and of the contextual memories …
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Investigations into the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy and maternal immune activation
… This thesis investigated the cellular and molecular changes in the amygdala in models of temporal lobe epilepsy (TLE) and maternal immune activation (MIA). The kainic acid (KA) model of temporal lobe epilepsy (TLE) was used to induce Ammon’s-horn sclerosis (AHS) and to investigate …
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Development of a Non-Invasive Proteomic Approach to Profiling Molecular Changes in the Microenvironment to Investigate Stages of Breast Health
Early detection of breast cancer is critical for increasing survival rates. However, currently available screening strategies provide ambiguous results, leaving invasive tissue biopsy procedures necessary for definitive diagnosis. Considerable efforts have investigated using nipple aspirate fluid …
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The differential effects of short-term physical exercise, environmental enrichment and their combination, and short- and long-term environmental enrichment on behavior and associated molecular changes in the brain of C57BL/6 mice
… activity, accompanied by neurobiological changes, such as enhanced inflammation, decreased neurotrophins, and altered neurotransmitter levels. Evidence suggests that external environmental conditions can modify the effects of aging. Environmental enrichment (EE), where the immediate …
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Exploring Risk Factors of Alzheimer’s Disease Using Mouse Models
… (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and compared their whole- and phosphoproteomes …
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The Role of Mitochondria in Oxygen Sensing of the Ductus Arteriosus and Fetal Pulmonary Arteries
… respectively. Objectives: 1) determine the molecular changes in human DA smooth muscle cells (DASMC) induced by exposure to postnatal oxygen concentrations, 2) examine the contribution of individual mitochondrial electron transport chain (ETC) subunits to DASMC oxygen response, and 3) …
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Effects of Natural Antioxidants on Motor and Cognitive Deficits in an Animal Model of Aging and Obesity and Dopaminergic-Like SH-SY5Y Cell Line
… to evaluate resveratrol-mediated behavioral and molecular changes in a novel over-eating induced obesity and aging model. Our results indicated that prolonged resveratrol supplementation affected molecular changes in the brain, muscle and bone that may be potentially be beneficial for combating …
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Mechanisms of Edema Clearance: The Central Role of Lymphatic Vessels and LYVE1 in Fluid Homeostasis
… this platform, we identified key structural and molecular changes that accompany compensatory lymphangiogenesis. Additionally, we investigated the role of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) in mediating lymphatic vessel function and promoting edema resolution. Together, …
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Understanding the neuroadaptations underlying the effects of (+)-methylenedioxymethamphetamine [(+)-MDMA; ecstasy]: Implications for the serotonin 5-HT2A receptor and its binding partners
… an enhancement of its behavioral effects. The molecular changes underlying behavioral sensitization may be linked to neuropsychological sequelae (e.g., depression, anxiety) seen upon withdrawal from MDMA exposure. Microarray analyses were conducted following administration of a behaviorally …
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The KATP -Knockout Mouse: A Model of Susceptibility to Post-Concussion Syndrome
… study was designed to assess behavioral and molecular changes post-mTBI in an animal model of genetic susceptibility to poor neurological outcomes, the Kir6.2-knockout mouse. We conducted multiple behavioral tests and analyzed the cellular stress response through assessment of heat shock …
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A two-stage thermal modification of wood
… are discussed in relation to anatomical and molecular changes found in wood after heat treatment. The results are based on investigations of a full-scale industrial heat treatment method under relative mild conditions (< 200°C) including a moist and dry treatment stage. Several changes and/or …
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Pathophysiological changes in cardiomyocyte metabolism and bioenergetics during stress-induced cardiomyopathy.
… thesis is focused on metabolic and bioenergetic changes in cardiomyocytes during stress exposure. Stress exposure leads to pathophysiological changes in myocardium, which can lead to heart failure. It is important to know exact pathophysiological changes to prevent the development of heart …
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The effects of histone acetylation on the maize allele PL1-blotched
… rather than uniform, pigmentation. At the molecular level, this phenotype is associated with low expression of pl1 mRNA, a novel pattern of DNA methylation and condensed chromatin structure. To ask if acetylation of nucleosomal histone proteins might be involved in regulating the chromatin …
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Multi-modal Multi-Level Neuroimaging Fusion with Modality-Aware Mask-Guided Attention and Deep Canonical Correlation Analysis to Improve Dementia Risk Prediction
… disorder characterized by structural and molecular changes in the brain. Early diagnosis and accurate subtyping are essential for timely intervention and therapeutic planning. This thesis presents a novel multimodal deep learning framework that integrates T1-weighted MRI and Amyloid PET …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive properties that allow them to migrate through the extracellular matrix. EMT inducers or regulators have been shown to induce cancer cells to form populations with cancer stem cell-like …
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Involvement of MicroRNAs in the Regulation of Porcine Follicle Maturation
… growth and maturation of the oocyte. The complex molecular changes that occur within follicular cells in response to hormone signaling have been overlaid with a network of non-coding microRNAs (miRNAs) that post-transcriptionally regulate gene expression. The somatic components of the ovary have …
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