Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 47 for “"Molecular biomarkers"”.
-
Concurrent detection and isolation of cellular and molecular biomarkers
… been developed for detecting either cellular or molecular targets, however there has not yet been a system that can simultaneously detect both cellular and molecular targets effectively. Molecule and cell-based assays are important because each type of target can tell a different story about the …
-
Gonadal intersex in teleosts: Mechanisms, molecular biomarkers and diagnostic assays
… field and laboratory studies to investigate the molecular signaling pathways behind the development of gonadal intersex; and 2) establish molecular biomarkers and assays for testing the ability of environmental pollutants to develop this condition using a battery of molecular, cellular and …
-
DNA adducts as molecular biomarkers of exposure to benzo(a)pyrene
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1997.
-
Molecular Biomarkers in Triple-Negative Breast Cancer // Молекулярни биомаркери при тройно негативни карциноми на гърдата
Тройно негативният карцином на гърдата (ТНКГ), характеризиращ се с липса на експресия на рецептори за естроген, прогестерон и HER2, е с най-агресивно поведение, най-висок риск от метастази и рецидив. Целта на проучването е да се изследва прогностичната ролята на тумор инфилтриращите лимфоцити …
-
Management during the dry period and its effect on hepatic and adipose tissue molecular biomarkers of metabolism and health in grazing dairy cows
A successful transition into lactation determines optimum production, reproduction, and health. The peripartum period is characterized by an inflammatory state that, if not controlled, could be detrimental to the cow. The first experiment examined hepatic and adipose gene expression in response to …
-
Protein regulation in Trichodesmium and other marine bacteria: observational and interpretive biomarkers of biogeochemical processes
… disparate ocean ecosystems. Towards this end, molecular biomarkers are important tools in chemical oceanography because they allow for both the observation and interpretation of microbial behavior. In this thesis, I use molecular biomarkers to develop a holistic, systems biology approach to the …
-
Rock hyraxes (Procavia capensis) and their environments : δ13Ccollagen and δ15Ncollagen as environmental indicators
… shifts in stable isotopes, palynology, and molecular biomarkers that appear to reflect environmental change. Previous studies conducted in east Africa have concluded that rock hyraxes are preferential grazers. There is comparatively little evidence, however, for the dietary preference of …
-
Assessment of Petroleum Hydrocarbon Contamination In Terrestrial Ecosystems Using Conventional and Novel Approaches
… of current toxicological tests, and identify molecular biomarkers in a model springtail species, Folsomia candida, suitable for high-throughput toxicity testing. Weathered PHC-contaminated soils from a Northwestern Canadian site were found to be non-toxic to native soil invertebrate and plant …
-
RNA sensing and programming platforms for mammalian synthetic Biology
… circuits. Generally these gene circuits sense molecular biomarkers, process these inputs and execute a desired calculated response. This is especially relevant for gene and cell therapies where integrating multiple disease-related inputs and/or sophisticated control could lead to safer and more …
-
Regulation of Survivin Gene Expression In The Human Endometrium and Endometrial Cancer
… (25). As of yet, there has not been a dependable molecular predictor of endometrial cancer occurrence in women with these predisposing factors. The goal of our lab is to identify genes that are aberrantly expressed in EC and may serve as molecular biomarkers of EC progression. One candidate …
-
Malignant Glioma: Chemosensitivity testing and Biomarkers
Chemosensitivity testing and molecular biomarkers are commonly used methods during the management of several types of malignant tumours in routine clinical practice. The present work attempts to transfer the use of these two concepts to the management of malignant gliomas. Chemosensitivity testing …
-
Molecular Determinants of Residual Disease In Ovarian Cancer
… clinical issue by identifying and validating molecular biomarkers that can predict the likelihood of residual disease in ovarian cancer patients. Using publically available databases and microarray datasets, we identify FABP4 and ADH1B as markers of residual disease since the high expression …
-
Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… with an elevation of several inflammatory biomarkers, suggesting a possible role for inflammation in its pathogenesis. We aimed to further characterise this relationship by prospectively analysing a wide variety of molecular biomarkers in a cohort of CSX patients thereby charting the …
-
Redox regulation of vascular NO bioavailability during hypoxia: implications for oxygen transport and exercise performance
… profile of these tissues whilst changes in molecular biomarkers of endothelial function could provide some insight into the mechanisms driving systemic and regional O2 delivery and vascular hypoxic sensing capabilities. The first study of this thesis examined the impact of acute hypoxia …
-
Identify Signature Genes/Pathways to Characterize Alzheimer's Disease Subtypes Based on Uncoupled Tauopathies and Cognitive Decline
… for disease prevention. By identifying specific molecular biomarkers associated with each subtype, I hope to help clinicians diagnose various AD subtypes at an earlier stage. In this work, I have performed transcriptomic and proteomic characterization of two atypical AD subtypes on two large …
-
High-Throughput Single-Cell Functional and Molecular Profiling of Immune Cells in Cancer Immunotherapy
… of potencies to understand the phenotypic, molecular, and functional contribution of infusion products at single-cell level. In the first part of this dissertation, we implemented Timelapse Imaging Microscopy in Nanowell Grids (TIMING) to demonstrate that while CD4+CAR+ (CAR4) cells killed …
-
Nonlinear optical microscopy and spectroscopy by pulse shaping of a coherent fiber supercontinuum
… of nonlinear optical imaging is the wealth of molecular contrast derived from various multiphoton processes. Two-photon and three-photon fluorescence microscopy visualizes endogenous fluorophores. Second and third harmonic generation microscopy maps optical non-centrosymmetry and heterogeneity. …
-
A systems approach to the different grades and progression of human astrocytoma
… the most aggressive glioblastoma (WHO grade 4). Molecular biomarkers or signatures—i.e., patterns of gene or protein expression that can reliably distinguish between each grade and provide insight into the underlying molecular events associated with tumor progression—have not yet been well …
-
Novel Diagnostic Methods for Rapid Detection and Identification of Bacterial Infections in Bovine Mastitis
… mass spectrometry was used to identify molecular biomarkers in mastitic milk. Diagnostic performance and individual markers were further investigated using transcriptomic studies. The second method used conserved species-specific primers designed from response regulators which were …
Page 1 of 3