Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Molecular biomarker"”.
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Carbon and sulfur isotopic constraints on Ediacaran biogeochemical processes, Huqf supergroups, Sultanate of Oman
… organic matter, supplemented by geochemical and molecular biomarker proxies, of strata from the Huqf Supergroup, Sultanate of Oman. Within Ediacaran strata, three successive stages of geochemical oxidation are observed and correlated to episodes of biological evolution. The second stage …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
… provided researchers with powerful new tools for molecular biomarker discovery that may benefit early screening of cancer. This dissertation outlines several key advances made toward the application of urinary metabolomics to cancer biomarker discovery. The term urinary metabolomics here refers to …
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Fluorescence correlation spectroscopy: ultrasensitive detection in clear and turbid media
… cerebrospinal fluid and other body fluids as a molecular biomarker for persons at risk of Alzheimer’s disease dementia. The technology could potentially be extended to the diagnosis and therapeutic monitoring of other protein neurologic diseases where oligomeric forms may play a role.
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The Prospects of Personalising Medicine
… patients based on evidence of commonly shared molecular biomarker status among patient subgroups. I argue that in many instances of its use, this strategy has low reliability because biomarker evidence lacks credibility. Lastly, in Chapter 5, I draw attention to African Traditional Medicine as …
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Bronchial gene expression associated with airway pre-malignancy and lung cancer subtypes
… gene expression profiling can identify molecular responses to carcinogen exposure and tumorigenesis. We have previously identified lung cancer-associated gene expression alterations in the normal bronchial airway epithelium of ever smokers with and without lung cancer. These alterations …
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Towards Deep-Sea Toxicology: Experimental Approaches With Echinoderms
… stenotopic<br/>Brissopsis lyrifera. A range of biomarkers was used to assess the responses of the echinoids to<br/>contaminant exposure. Compared with the significant cytological and molecular (assess via qPCR)<br/>responses in P. miliaris, a reduced capacity to respond to contaminant exposure …
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Investigation of key non-coding and coding genes in cutaneous melanomagenesis
… melanoma, an improved understanding of the molecular pathogenesis of melanoma and exploration of more reliable molecular biomarkers are particularly essential. Two different types of molecular biomarker for melanoma have been investigated in this thesis. microRNAs (miRNAs) are …
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Gonadal intersex in teleosts: Mechanisms, molecular biomarkers and diagnostic assays
… field and laboratory studies to investigate the molecular signaling pathways behind the development of gonadal intersex; and 2) establish molecular biomarkers and assays for testing the ability of environmental pollutants to develop this condition using a battery of molecular, cellular and …