Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 118 for “"Molecular and Cellular Neuroscience"”.
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The Molecular Components of Estrogen Receptor Beta (ERβ) Signaling in Neuronal Sytems
… how the brain is changed by estrogen deprivation and also how aging influences these changes. The Women's Health Initiative (WHI) study spurred rigorous debate regarding estrogen therapy for postmenopausal women due to dichotomous effects of estrogens in menopausal and post-menopausal women. …
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Revised - THE ROLE OF GAD67/65 IN THE THERAPEUTIC EFFECTS OF KETAMINE AND FLUOXETINE IN FEAR-CONDITIONED MICE
… (PTSD) is a chronic psychiatric disorder and the most common disorder following exposure to a traumatic event. The most commonly used drugs in PTSD treatment are selective serotonin reuptake inhibitors (SSRIs), though only about 50% of patients respond to this treatment. Previous work in …
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Exploring the Role of Oxytocin Signaling in Aging Using Caenorhabditis elegans
<p>No abstract available</p>
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Modification of Aplysia Feeding Network By L-Dopa and Dopamine-Dependent Learning
… of neuronal networks in the animal kingdom and has a well-established role in modulating motor behavior and encoding reward information. Although the effects of DA and DA-dependent learning at the behavioral and molecular levels are well-understood, many questions still remain concerning the …
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Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
… from Retinal Ribbon Synapses Photoreceptors and bipolar cells in the retina form specialized chemical synapses called ribbon synapses. This type of synapse differs physiologically from “conventional” chemical synapses. While “conventional” synapses exocytose neurotransmitter-filled vesicles …
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Delineating The Mechanism(S) of Bdnf/Trkb Mediated Proliferation In Neuroblastoma
… to patient outcome. High expression of TrkA and TrkC receptors have been linked to favorable biological features and high patient survival, while TrkB is expressed in unfavorable, aggressive tumors. Several studies suggest that high levels and activation of TrkB by its ligand brain-derived …
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Repurposing BT-11 to Treat Alzheimer’s Disease: Exploring the Glutathione-s-transferase LANCL2 as a Target
… that ultimately results in neurodegeneration and cognitive dysfunction associated with the disease. In building a multiplex model of Alzheimer’s it is important to understand its specific biological mechanisms. One of these key pathological mechanisms is neuroinflammation. Understanding the …
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Genetic Circadian Mosaics and the Clock Network’s Contributions to Sleep
<p>Circadian rhythms are physiological and behavioral changes which follow a 24-hour cycle. <em>Drosophila Melanogaster</em>’s circadian clock neuronal network (CCNN) has been identified and several subpopulations have been characterized based on previous studies; the classifications of …
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Non-canonical Activation of CREB/crh-1 Mediates Neuroprotection in a <i>Caenorhabditis elegans</i> Model of Excitotoxic Necrosis
… kinases in the cytoplasm or nucleus, and the activation of CREB by CRTC (an important cofactor). Using a <em>C. elegans</em> model of excitotoxicity, we demonstrate that CREB’s neuroprotective effect is mainly seen in neurons exposed to a moderate insult. Surprisingly, we find that …
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Capsinoids, Non-Pungent TRPV1 Agonists, Induce a Mild Hypothermia That Provides Short- and Long-Term Neuroprotection After Ischemic Stroke
… neuroprotection in instances of cardiac arrest and neonatal hypoxia/ischemia but faces different challenges in application to stroke due to the activation of cold defense mechanisms in conscious patients. This dissertation examines the efficacy and specificity of capsinoids (a purified mixture …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
<p>Maintenance of mitochondrial transport and clearance at the pre- and post-synaptic terminal is an essential function of neuromuscular junctions to meet their high energy demands. Damaged or dysfunctional mitochondria can put stress on these synaptic junctions, ultimately leading to the …
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