Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Molecular and Cellular Biology"”.
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Distinct Examples of Immunologic Analysis in Molecular and Cellular Biology: Small Nuclear Ribonucleoproteins and the T Cell Receptor
<p>Since the discovery (Tan and Kunkel, 1966; Mattioli and Peichlin, 1971; Sharp, et al., 1972) of human SLE autoantibodies directed against RNA-protein complexes in eucaryotic nuclei, a great deal of interest has been generated regarding both the relationships of antibody specificities to disease …
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Using light to control and investigate cell biology
… to be a powerful tool for the interrogation of molecular and cellular biology. Beyond its use in microscopic applications, light has emerged as an attractive modulator of cellular function. Within the last two decades, scientists have begun to harness the power of light and light-sensitive …
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United States stem cells research boundaries
… to be crucial particularly in fields such as molecular and cellular biology in which the materiality of research renders the process of replication and validation more complex. Scientific infrastructure has many interconnecting elements such as the ability to exchange material used in …
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Exploring the mechanism of SHP2 and EGFR/HER2 cooperation in breast cancer cell signaling
… of receptor tyrosine kinases like EGFR and HER2. As such, targeting of SHP2 is being recognized as a potentially viable therapeutic option in HER2-positive and triple-negative breast cancers. In this report, I employed molecular and cellular biology techniques to further elucidate the …
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A microfluidic platform for combinatorial experiments
Experiments in biology are often combinatorial in nature and require analysis of large multi-dimensional spaces, but the scales of these experiments are limited by logistical complexity, cost, and reagent consumption. By miniaturizing experiments across nanoliter-scale emulsions that can be …
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Characterization of Cellular and Genomic Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells
… most frequently-occurring non-cutaneous cancer and the second-deadliest cancer in American men. Early-stage prostate cancer can be eradicated by surgery or radiation with a 100% 5-year survival rate. Late-stage prostate cancer is treated with hormone ablation therapy, but the 5-year survival …
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Development Of Novel Radiotracers For Pet Imaging Of Hdac-Mediated Epigenetic Regulation
… has become a rapidly growing, highly innovative and influential field of biology and medicine. Protein acetylation and deacetylation, two key epigenetic regulatory mechanisms, are mediated by histone acetylase transferases (HATs) and histone deacetylases (HDACs), respectively. To date, the vast …
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Development of CRISPR/Cas9-based gene drive biotechnology in S. cerevisiae
… for investigating the fundamental aspects of molecular and cellular biology. It also can be used to evaluate the technical feasibility of new technologies in eukaryotic cells. In our lab, we aimed to use Saccharomyces cerevisiae as a model to develop CRISPR/Cas9-based gene drive biotechnology. …
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Microfluidic Engineering for Ultrasensitive Molecular Analysis of cells
… of microfluidic technology for ultrasensitive and fast molecular analysis of cells. Chromatin immunoprecipitation (ChIP) assay followed by next generation sequencing serves as the primary technique to characterize the genomic locations associated with histone modifications. However, …
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Development of a Dusky kob scFv gene phage display library for the discovery of antibodies to Brome mosaic virus - a proxy for a novel, emerging fish pathogen
… to infection by opportunistic pathogens and parasites. Antibody phage display is a method that allows foreign peptides or proteins to be expressed on the phage surface through translational fusion with phage coat proteins. Consequently, antibodies expressed by a diverse repertoire of …
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TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… expression of TBX2 is observed in many cancers, and serves as an oncogene to maintain tumor cell proliferative and malignant properties. We found that TBX2 was expressed in both embryonic myoblasts and adult proliferative satellite cells, but was quickly down regulated during muscle …
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An <i>in vitro</i> human 3D co-culture model to study endothelial-astrocyte interactions
… brain microvascular endothelial cells (BMVEC) and astrocytes occur. Most of the knowledge in this area of research is derived from <i>in vitro</i> eo-culture models in which astrocytes are cultured on a stiff, two-dimensional (2D) surface. Three-dimensional (3D) culture models closely mimic the …
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Nanolayer multi-agent scaled delivery from implant surface
… infection. Only recently have we come to understand the significance of addressing infection during the bone wound healing process; however, to apply this understanding toward an effective treatment requires the ability to deliver exacting amounts of therapeutics of different types over the …