Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 168 for “"Molecular Targets"”.
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G-Quadruplexes As Molecular Targets For Transcriptional Control
… shift assays differentiated inter- and intra-molecular structures, further distinguishing the distribution of isoforms. Other studies included chemical footprinting, FRET compound screening, luciferase, and in vitro cytotoxicity. This comprehensive understanding of the physiological conditions …
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… neuropathic pain. Finally, we explored the molecular mechanism of a selective T-type calcium channel blocker. Our data demonstrated a mix of loss- and gain-of-function in the CaV2.1 channel mutant P2455H, and a gain-of-function in a CaV3.1 channel variant (R706Q). For the CaV3.2 channel …
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Identifying Molecular Targets and Validating Novel Therapies For Ovarian Cancer
… effects and impact relevant oncogenic gene targets, such as Notch3,<strong> </strong>in this disease. In our pre-clinical models, we demonstrated that BETis produce therapeutic effects and prolong survival. Furthermore, we discovered that BRD4 directly regulates Notch3 transcription and its …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
… remains limited by scant data on druggable targets in dogs. This doctoral thesis aimed to systematically assess the expression and distribution of selected molecular targets in canine tumors, focusing on aggressive, frequent, or therapeutically challenging neoplasms, and to evaluate their …
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Proteomic investigation of the molecular targets of mycophenolic acid in human cells
… present study was undertaken to identify novel molecular targets of MPA using a proteomics approach. Two dimensional gel electrophoresis (2-DE) and mass spectrometry were used to identify proteome alterations in human embryonic cells (HEK-293) following exposure to therapeutic concentrations of …
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Unique glycolytic pathway enzymes as molecular targets for novel anti-cryptosporidial drugs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Identification of molecular targets regulating fatty acid synthesis in bovine mammary epithelial cells
… objective of the present studies was to identify molecular proteins that regulate fatty acid synthesis in bovine mammary epithelial cells. The regulation of lipogenic genes including acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) is controlled by transcription factors including sterol …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
… deep sequencing) to determine genome wide gene targets of three histone modifications: H3K4me3, H3K9me3 and H3K27me3. Our data suggest these chromatin marks are associated with genes responsible for cellular organization and morphology, proliferation and survival, neuron development. Taken …
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Identification of Molecular Targets for the Treatment of the Skeletal Phenotype in Lysosomal Storage Disorders
Autophagy is a lysosomal pathway deputed to the recycling of cellular components. Regulation of autophagy is essential for tissue homeostasis. The mTORC1 kinase tunes autophagy according to nutrient levels and environmental factors. Recently the laboratory in which I performed the experiments used …
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An in vitro chemogenomic screening system to identify the molecular targets of antimalarial drug candidates
… promising hit compounds, but elucidating the targets of these compounds, often a necessary step in the hit-to-lead development process, has been slow. This is because target identification has rested primarily on one technique, *in vitro* evolution and whole genome sequencing (IVIEWGA), which …
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Functional Investigation of RNA Viral Helicases as Molecular Targets for the Discovery of Novel Antiviral Agents
… proteins across several viral families, are a molecular class still underexplored, that lacks approved antiviral agents. In this respect, the identification of first-in-class inhibitor scaffolds is a promising achievement to pursue. The work is focused on the helicases of Coronaviruses, …
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Uncovering Molecular Targets to Overcome Immunosuppression In Non-Small Cell Lung Cancer With Acquired Tki Resistance
… This work seeks to further elucidate the role of molecular targets, like IL-6 and estrogen, in promoting immunosuppression in NSCLC tumors with acquired resistance to an EGFR-TKI or anti-VEGF therapy. Using preclinical in vitro human NSCLC cell lines and in vivo murine NSCLC models in addition to …
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
Cystic fibrosis (CF) is an autosomal recessive disease, caused by mutations in the gene which codes for the CF transmembrane conductance regulator (CFTR). Mutations in CFTR cause multi-organ dysfunction, including in the lungs, pancreas, gastro-intestinal system and the reproductive system. …
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Unravelling novel molecular targets for photobiomodulation in human hair follicle towards the development of more effective light-based therapies for hair growth
… by a virtual lack of proof about the exact molecular targets that mediate the physiological response of skin and hair follicles (HF) to low levels of light. The goal of this project was to investigate the expression of light-sensitive receptors in the human HF and to study the impact of …
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Synthesis of bespoke matrices to investigate a novel anti-tumour molecular target using affinity chromatography. The design, synthesis and evaluation of biotinylated biarylheterocycles used as novel affinity probes in the identification of anti-tumour molecular targets.
… function. The identity of likely protein targets was explored using a chemical proteomic strategy. Bespoke affinity matrices for chromatography were prepared in which test compounds were attached to a solid support through a biotin tag. A synthetic route to hit compounds containing a …
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