Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Molecular Signaling"”.
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Molecular Signaling and Agonist Discovery for GPR52
… work herein describes the investigation of GPR52 signaling mechanisms, molecular determinants for GPR52 activation, and discovery of biased GPR52 agonists. GPR52 was determined to couple to both Gs and Golf to increase cAMP signaling, with constitutive activity driven by Gs. GPR52 is co-expressed …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
… invading pathogens. While these matrix-specific signaling events have emerged as crucial elements for proper migration and recruitment of neutrophil cells, the underlying signaling networks remain poorly defined. We have identified Pyk2, a FAK (focal adhesion kinase) family non-receptor tyrosine …
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Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation
… a functional link between cAMP and ESR1 signaling. Using a proteomic approach, we identified MED1 as a target of cAMP-activated protein kinase (PKA) during HESC differentiation. The PKA-dependent phosphorylation of MED1 enhanced its ability to interact efficiently with ESR1. Furthermore, …
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Interaction of Quantal Inhibitory and Excitatory Neurotransmission in Regulation of Synaptic Homeostasis via Molecular Signaling
… Therefore, studying the organization and signaling capacity of the variety of synapses present in our nervous system is critical to understanding how information is shaped and communicated between neurons. Neurotransmission can be classified into two broad types: spontaneous and evoked. …
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LisNRs : a novel class of liposomal contrast agents for molecular MRI
Biological systems depend on numerous molecular messengers that transduce information across large distances. Understanding the spatial and temporal dynamics of molecular signaling networks is crucial for the construction of systems- and organism-level models of biological function. Molecular …
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Bioprobes and Genetics Reveal the Signal Integration That Initiates Dendrites in a Neuron in Vivo
… rearrangements by orchestrating intrinsic signaling molecules. Monomeric Rho GTPases are capable of mediating diverse transmembrane signal pathways. However, the means to monitor and dissect molecular signaling within a subcellular compartment are limited, and the role of Rho GTPases and …
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Guidance of Developing Motor Neurons into the Periphery
… MNs subtypes begins with Sonic Hedgehog (Shh) signaling in the spinal cord and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. …
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Dact Family Molecules In Wnt Signaling In Mouse Development
The Wnt: Wingless-Integration) molecular signaling pathways are known to be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted …
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Uncovering Phosphorylation Circuitries that Control DNA Replication Fork Dynamics
… overcome replication barriers by mounting robust molecular signaling responses. Kinases phosphorylate hundreds of proteins that halt cellular processes, facilitate the removal of replication barriers, and promote genomic stability. Kinase mediated signaling ensures that errors with DNA are fixed …
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The Involvement of Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) as a Critical Modulator of Macrophage Migration
… conditions, is mediated by integrated cellular signaling processes and cytoskeleton rearrangement. Recent advances indicate that the innate immunity signaling process plays a key role in the regulation of macrophage migration. Furthermore, our lab has provided evidence demonstrating the …
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Models and analysis of yeast mating response : tools for model building, from documentation to time-dependent stimulation
Molecular signaling systems allow cells to sense and respond to environmental stimuli. Quantitative modeling can be a valuable tool for evaluating and extending our understanding of signaling systems. In particular, studies of the mating pheromone response system in yeast (Saccharomyces cerevisiae) …
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Towards brain-wide noninvasive molecular imaging
An intricate interplay of signaling molecules underlies brain activity, yet studying these molecular events in living whole organisms remains a challenge. Magnetic resonance imaging (MRI) is the most promising imaging modality for development of molecular signaling sensors with deeper tissue …
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AKAP12 Signalosome Regulates Cardiac β2-Adrenergic Receptor Signaling
… extensive network of intertwined intracellular signaling pathways regulates cardiac remodeling (a general determinant of HF). The ability of signalosomes (molecular signaling complexes) to compartmentalize several cellular pathways has been recently established. One example of these signalosomes …
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Gonadal intersex in teleosts: Mechanisms, molecular biomarkers and diagnostic assays
… field and laboratory studies to investigate the molecular signaling pathways behind the development of gonadal intersex; and 2) establish molecular biomarkers and assays for testing the ability of environmental pollutants to develop this condition using a battery of molecular, cellular and …
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The Role of Oxygen and Oxygen-Dependent Enzymes in Protein Folding, Metabolism, and Redox Homeostasis
… Here, we provide a comprehensive review on how molecular signaling in hypoxia represents an intricate, coordinated response triggered by oxygen dependent enzymes. Our work also highlights the lack of understanding of the requirement for oxygen in protein folding and the biological roles of an …
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The Molecular Components of Estrogen Receptor Beta (ERβ) Signaling in Neuronal Sytems
… there is an age-related `switch' in estrogen signaling around menopause. These age-related effects of HT expose a gap in scientific knowledge as to how estrogen receptors, ERα and ERβ signal when the body is deprived of estrogen and under the natural context of aging. ERβ …
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The Neural Circuitry Of Social Behavior In C. elegans
… the surrounding environment. Understanding the molecular and cellular underpinnings of these social behaviors remains a central challenge in neurobiology. I used the nematode C. elegans as a model system to study the genetics and neural circuitry that underlie social behavior. First, I evaluated …
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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
… that responds to its external environment. Cell signaling cascades are initiated within bone cells when changes in mechanical loading occur. To describe these molecular signaling networks that sense a mechanical signal and convert it into a transcriptional response, we proposed the mechanosome …
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Bioimage informatics for understanding the effects of chemotherapy on cellular signaling, structure, and function
… Consequently, quantitative characterization of molecular signaling pathways and changes in cancer cell phenotypes induced by chemotherapy through the use of in vitro model systems would expand our understanding of drug mechanisms and provide for putative strategies to counteract drug-induced …
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Role of 5-Lipoxygenase in Interleukin-4-Induced Oxidative Stress and Inflammation in Vascular Endothelium
… events of atherosclerosis. However, the detailed molecular signaling mechanisms underlying this process are not yet completely understood. Recently, the role of interleukin-4 (IL-4) in atherogenesis became controversial and gained attention. IL-4 is a pleiotropic immunomodulatory cytokine secreted …
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