Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Molecular Response"”.
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Local Correlation: Implementation and Application to Molecular Response Properties
… scales linearly (in the asymptotic limit) with molecular size. Pulay and Saebø first applied their methods to configuration interaction and later to Møller-Plesset perturbation theory. Werner et al. have have extended the local correlation scheme of Pulay and Saebø to coupled-cluster theory. One …
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Regional whole plant and molecular response of Kochia scoparia to glyphosate
… Dakota, and Alberta. Whole plant glyphosate dose response and shikimate assays were used to confirm resistance and assess the level of resistance. Then PCR, quantitative PCR, sequencing, and immunoblotting techniques were used to determine the mechanism responsible for glyphosate resistance. …
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Molecular response of soybean (Glycine max (L.) Merr) to Phialophora gregata
… determine the mechanism of this resistance, the response of whole plants and soybean cells in culture was studied at the biochemical and molecular level. Soybean cultured cells were treated with culture filtrate of the fungus and the proteins synthesized by the plant cells were extracted at times …
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Characterising the molecular response of Agaricus bisporus to mushroom virus X infection
… A. bisporus. Scant focus has been placed on the molecular responses from the host during infection. The work presented herein provides novel genomic, transcriptomic, proteomic and cellular resources to help address the gaps in knowledge concerning MVX and A. bisporus. The first whole genome …
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Molecular Response of Retinal Pigment Epithelial Cells to Oxidized Lipoproteins: Global and Targeted Studies
… examinations of biological systems at the molecular level complement targeted approaches to scientific inquiry that focus on specific subsets of biomolecules, or on a single molecule of interest. In this dissertation, we utilized both the discovery-based approach to evaluate the proteomics …
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Towards Efficient and Scalable Electronic Structure Methods for the Treatment of Relativistic Effects and Molecular Response
… computer implementation in order to study molecular systems at experimentally relevant scales. Thus, this work outlines several advances in the development of efficient and scalable electronic structure methods for the treatment of relativistic effects and molecular response. As such, the …
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Role of miR-29 family in molecular response to exercise: evaluation of therapeutic targets in neurodegenerative processes
El objetivo general de esta Tesis es estudiar el papel de la familia miR-29 en la adaptación al entrenamiento de resistencia y de fuerza, durante un periodo de cuatro semanas, a través de la comunicación mediada por VEs. Los objetivos específicos consistieron en: 1) caracterizar el perfil de miARN …
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Molecular Expression of Neuroprotective and Neurodestructive Signaling Systems Following Axotomy-Induced Target Disconnection: Relevance to ALS
… genes and suppression of the astrocytic response. Experiments within this dissertation evaluated whether axotomy-induced molecular response in pre-symptomatic SOD1 mice, resembles the disease-induced molecular response within the facial nucleus in symptomatic SOD1 mice. This dissertation …
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The impact of acute heat exposure on the heat shock response (HSR) between males and females
… adults, the influence of ovarian hormones on the molecular response remains unclear, despite their documented role in thermoregulation. This study investigated the molecular response to acute heat stress in males (n=11), eumenorrheic (EUM) females in the mid-luteal phase (n=10), and combined …
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The adaptive response of humans to exercise: Impact of exercise intensity, fibre-type specific responses and molecular patterns of response
… the current understanding of the adaptive response to exercise in humans, this dissertation performed a series of studies designed to examine the impact of training intensity and mode on aerobic capacity and performance, fibre-type specific adaptations to training, and individual patterns …
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The mechanics of mechanotransduction : analyses of cell perturbation
… the cell are candidate mechanosensors and their molecular response to force was hence investigated, A generic model of protein extension under external forcing was created inspired by Kramers theory for reaction rate kinetics in liquids.
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Semiclassical Modeling of Optical Properties of Molecules in Cavity Environments
… provide insights into the effect of collective molecular response on different optical processes involved in such experiments.
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Mechanochromism and Strain-Induced Crystallization in Thiol-yne-derived Stereoelastomers
… is associated with covalent mechanochemical responses, raising the possibility of an interplay between the macroscopic response of SIC, and the molecular response of mechanophore activation. Here we report thiol-yne-derived stereoelastomers, doped covalently with a dipropiolate-derivatized …
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Atomistic simulations of elastic-plastic deformation of amorphous polymers
… work, the thermo-mechanical behavior and the molecular-level origins of plastic deformation of an amorphous glassy polymer were studied using atomistic simulations. Understanding of the molecular response will aid the development of physics-based continuum level models for these materials. A …
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Prognostic markers associated with tyrosine kinase inhibitor treatment response and maintenance of treatment free remission in chronic myeloid leukaemia
… kinase inhibitors (TKIs). However, treatment responses are highly heterogeneous. The aim of this thesis is to identify prognostic markers that may help individualise treatment and optimise outcome by stratifying patients into risk groups. Selective treatment intensification is important - more …
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Implications of the interactions between genetic background and dietary phosphorus on porcine muscle
… of P utilization. Lack of understanding of the molecular response of skeletal muscle to dietary P and the influence of genetics has hindered our understanding of P homeostatic mechanisms. The objectives of my PhD research are to identify changes in gene expression in growing porcine muscle …
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Investigations into the Ulnar Response to Mechanical Stimuli Activating Lamellar and Woven Bone Formation
… mechanical loading. Woven bone forms rapidly in response to damaging loading in a disorganized manner with low mineral density. In contrast, lamellar bone formation can be induced in the absence of damage, and is characterized by its slow, organized deposition and high density. In this …
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Identification of Chlamydial Iron-Responsive Proteins during Intracellular Growth.
… studied organisms rely on iron for growth. In response to iron restriction, the chlamydial developmental cycle arrests at the intracellular reticulate body stage, resulting in a phenomenon termed persistence. Persistence likely plays a role in chlamydial pathogenesis through the expression of …
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Role of the NF-kappaB-HIF Crosstalk in Inflammation and Hypoxia
… essential component responsible to regulate the molecular response to hypoxia in the cell is the transcription factor called Hypoxia Inducible Factor (HIF). HIF has recently been associated with a role in inflammation and immunity. Importantly, HIF-1alpha has shown to be regulated by the major …
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Microrna Functions In Uv-Induced Cutaneous Squamous Cell Carcinoma
… little is understood about the early molecular response of human skin to UV exposure and its connection to acute wounding and cuSCC. Thus, our goal is to find common and specific signatures driven by UV-exposure and wounding as a means of developing new approaches for treating and …
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