Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"Molecular Pathology."”.
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Life Style, Molecular Pathology, and Breast Cancer Risk
The breast cancer diagnosis covers a wide range of tumours with different geno- and phenotypic characteristics. The diversity among studies on life-style factors and their impact on breast cancer risk might be clarified by recognizing breast cancer as a heterogeneous disease. A major aim of this …
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Theoretical and computational investigations of membrane associated molecular pathology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Molecular Pathology: Potential Biomarkers For The Detection Of Down Syndrome Pregnancies
Down Syndrome (DS), also called trisomy 21, is the most common non- lethal fetal aneuploidy that affects 1 in 800 live births. The disease appears mostly due to the existence of an extra copy of chromosome 21. In the UK, the screening of DS is offered to all pregnant women in the antena- tal care …
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The molecular pathology of BRCA1 and BRCA2 in breast cancer patients from the West of Scotland
Abstract available p. i-iii
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
… experience disease relapse following surgery. Molecular and histological subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of epithelial-to-mesenchymal transition (EMT) signalling and an abundance of stroma (particularly fibroblasts) in their tumour …
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The application of genomic technologies to cancer and companion diagnostics.
… a wave of change in our understanding of its molecular pathology. Molecular pathology and personalised medicine are being driven by discoveries in genomics, and genomics is being driven by the development of faster, better and cheaper genome sequencing. The next decade is likely to see …
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Synaptic loss in the primary tauopathies of Progressive Supranuclear Palsy and Corticobasal Degeneration
… density in vivo with dynamic [11C]UCB-J PET, and molecular pathology with [18F]AV1451 PET. Brain structural changes are quantified by MRI. Disease severity and cognition are assessed with the PSP rating scale, and neuropsychological tests. Patients with CBD are negative on amyloid-imaging …
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Owning the code of life : human gene patents in America
… Supreme Court heard the case of Association of Molecular Pathology v. Myriad Genetics. The case asked one question: are human genes patentable? Gene patents became commonplace during the biotechnology revolution of the 1980s, but generated a complex web of moral, legal, and biological questions. …
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… cases, 30% are additionally classified with TNBC molecular pathology, a diagnosis that significantly worsens patient’s prognosis. The current lack of TNBC and IBC molecular understanding prevents the development of effective therapeutic strategies. To identify effective treatments, we explored …
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Virtual reality navigation assessment and 7 tesla MR imaging of the entorhinal-hippocampal circuit in asymptomatic at-risk Alzheimer's disease
… aiming to understand how the effect of AD molecular pathology on cellular function results in clinical manifestations of disease.
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Loss of rad51 in zebrafish (Danio rerio): a novel Fanconi anaemia model
… and cancer predisposition. The cellular and molecular pathology of FA is poorly understood, resulting in a severe lack of effective treatment options. In this thesis, I describe the first viable vertebrate model of RAD51 loss. Phenotypic characterisation of zebrafish rad51 loss-of-function …
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Epidemiological risk factors, related biomarkers and oesophageal adenocarcinoma survival
… review and three cohort studies of which two had molecular pathological epidemiology components.<br/><br/>A systematic review and meta-analysis investigated the association between alcohol, smoking and oesophageal cancer survival. In the smoking analysis there was no significant difference in …
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Hippocampal Subfield Transcriptome Analysis in Schizophrenia Psychosis
… symptom manifestations of schizophrenia lack a molecular pathology. Consequently, advances in novel treatment directions are limited. Schizophrenia is recognized as a polygenic disorder influenced by environmental factors. This dissertation aims to examine this polygenic nature of this disorder. …
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Elucidation of the occurrence of extracolonic cancers in Lynch syndrome
… dominant mode of inheritance. Determine the molecular pathology of extracolonic cancers in Lynch syndrome and to elucidate whether or not the occurrence of these extracolonic cancers are a direct result of the mismatch repair deficiency. First, a modifier study was performed assessing the …
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Cotranslational Folding of CFTR
… of CF mandates the understanding of the molecular events leading to CFTR loss-of-function. The mechanisms by which different mutations throughout the CFTR protein result in misfolding are unclear. The correction of these processes and ultimately the treatment of CF require elucidation of …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
… factors play an important role in the ASD pathology. It has been shown that there is a remarkable genetic heterogeneity among ASD cases and thousands of genes may be associated with this disorder. The human brain can be separated into different regions in terms of their functions, and these …
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Analisi genetico-molecolare dei linfomi a cellule T periferiche
Molecular profiling of Peripheral T-cell lymphomas not otherwise specified Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of tumors that the WHO classification basically subdivides into specified and not otherwise specified (NOS). In Western countries, they represent around 12% of …
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Inorganic nanoparticles for applications in biomedical sciences
… are available for NSCLC because of its complex molecular pathology. CD22 is an adhesion molecule that is shown to be broadly expressed on NSCLC cell lines. Hence, in this project, we developed CD22 targeted gold nanoparticles to deliver Pt(IV) complex for the treatment of NSCLC. Synthesis and …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
Herpes Simplex Virus (HSV) – 1 also known as Human Herpes Virus (HHV) – 1 is a common infectious agent of humans which can cause a wide variety of clinical outcomes, ranging from mild mucocutaneous lesions to long term morbidity and possible mortality. Viral entry into cells requires the …
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Constraints on the CD8 T cell response in chronic HBV infection
The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total …
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