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Showing 1 to 20 of 149 for “"Molecular Mass"”.
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Expression and function of low molecular mass PLA2S
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The use of liquid-chromatography mass spectrometry for the absolute quantitation for bio-analytes: fro small molecular mass compounds towards larger molecular mass proteins
… for the absolute quantitation of the small molecular mass compounds pyrimethamine/sulfamethoxypyrazine and glycopyrrolate. Moreover, also for the larger molecular mass protein cystatin C was mass spectrometry investigated for its absolute quantitation. This, by means of marker peptides. In …
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Low molecular mass proteins as markers for renal function and dialysis efficiency
… were tested for their capacity to remove low molecular mass proteins (LMMP) and thus their potential for treatment of patients with kidney failure. The LMMP have been proposed to be uraemic toxins and must therefore be removed from the circulation. The result from our study showed that …
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Laser-Ionization Time-of-Flight Mass Spectrometry of High Molecular Mass Inorganic Complexes
Laser-Ionization Time-of-Flight Mass Spectrometry (LI-TOF-MS) is a sophisticated tool for the molecular-weight determination and structural characterization of a variety of molecules. Advances in instrumentation and ionization methods have recently expanded its role in the analysis of high-mass …
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Enabling early stage drug discovery targeting high molecular mass penicillin-binding proteins in <i>Yersinia pestis</i>
… of interest are given in Chapter one. High molecular mass (HMM) PBPs are well-established targets of β-lactam antibiotics. However, only in the past two decades has information about their structure started to emerge and the application of structure-based drug design against these proteins …
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Molecular characterisation and functional properties of gum arabic
… chromatography (gpc) was used to isolate several molecular mass components of gum arabic. The u. v. (218 nm) gpc elution profile showed the presence of several prominent peaks; however, only one major peak (FAw 3.8 x 10-9 g moll) and a minor peak (FAw 1.45 x 106 g mol-1) were observed in …
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Thermodynamic properties of diamino-diamide ligand as potential anti-inflammatory agent
It has been found that low molecular mass copper(II) complexes are effective in the treatment of rheumatoid) arthritis (RA). Increasing the amount of copper associated with low molecular mass ligands in plasma helps to alleviate the symptoms of rheumatoid arthritis. Low molecular weight ligand, …
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Non-isocyanate routes to urethane-polymers
… chlorine-waste stream. The processing of high molecular mass specialty polyurethanes regularly requires the use of organic solvents. This research aims to address these issues by separately employing enzyme-catalysis in order to synthesise high molecular mass polyurethanes and by investigating …
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Physico-chemical properties of polypropylene glycols
Poly(propylene glycol) (PPG) samples of different molecular mass were characterized using differential scanning calorimetry, modulated differential scanning calorimetry, thermogravimetry and thermally stimulated current (TSC) spectroscopy. It was shown, by TSC, that the glass transition temperature …
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STRUCTURE-FUNCTION ANALYSIS OF THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1
… Electrophoresis, hENTl was found to possess a molecular mass of 160 kDa. This is approximately three times the size of the known 55kDa hENTl monomer. Targeted site-directed mutagenesis of GxxxG motifs within the transporter, known to play a role in oligomerization, did not appear to affect the …
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Urinary Excretion of (1-3)-Beta-D-Glucans.
… fungi and bacteria; they are pathogen associated molecular patterns that circulate during infection and modulate immunity. Our laboratory has previously established the pharmacokinetics of intravenously and orally administered glucans; the present studies investigated the renal excretion of …
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The flocculation of kaolin with polyacrylamides
Flocculation occurs when high molecular mass organic molecules form bridges between particles, causing them to aggregate. This modifies the sedimentation properties of the mineral slurry. Thus classical measures of flocculation, among them the settled bed height and the supernatant turbidity, have …
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A chromatographic investigation into the reactions of urea and formaldehyde.
… rapid reproducible method for investigating the molecular mass distribution of urea formaldehyde resins by size exclusion chromatography has been developed. By using lithium chloride in dimethylformamide as the solvent for chromatography, solubility and molecular association problems have been …
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Biochemical and Molecular Approaches to Characterizing the Myrosinase Enzyme System in Horseradish (Armoracia Rusticana)
… with a deduced protein of 538 amino acid and molecular mass of 61.6 kDa. Heterologous expression of ArM1 in Spodoptera frugiperda insect cells resulted in an immune active myrosinase protein product and gave rise to a band of approximately 66 kDa in western blot analysis. ArM1 has the highest …
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Characterization of the nifUHD cluster and a new myoglobin-like gene from Nostoc commune UTEX 584
… has a predicted length of 118 amino acids and molecular mass of 12,906 Da. A PCR copy of the gene (<i>glbN</i>) was cloned for overexpression of the protein. The recombinant protein was purified and used for spectral analysis and for the production of polyclonal antisera. Treatment of the …
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Purification of Aspartate Transcarbamoylase from Moraxella (Branhamella) catarrhalis
… has been purified. The holoenzyme has a molecular mass of approximately 510kDa, harbors predominantly positive charges and is hydrophobic in nature. The holoenzyme possesses two subunits, a smaller one of 40 kDa and a larger one of 45 kDa. A third polypeptide has been found to contribute …
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Regulation and function of hyaluronan binding by CD44 in the immune system
… and the size of hyaluronan itself, with high molecular mass hyaluronan having a greater effect than intermediate or low molecular mass hyaluronan. The addition of hyaluronan to pre-activated Jurkat T cells induced rapid cell death independently of Fas and caspase activation, identifying a …
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Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
… of A3G from enzymatically-inactive high molecular mass complex to enzymatically-active low molecular mass complex. Virion-associated A3G exhibited elevated cytidine deaminase activity in the presence of RNase L. These results supported a regulatory mechanism for A3G during HIV-1 …
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The development of new methods for the assessment of oxygen radical-mediated oxidative damage to biomolecules with special reference to lipids
… hydroxyl radical (.OH) which is mediated by low-molecular-mass iron chelates such as iron-citrate complexes. The .OH radical is extremely reactive and proving its formation in vivo is very difficult. Hence, assays for the assessment of .OH radical activity in the inflamed rheumatoid joint have …
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Characterization of Moraxella bovis Aspartate Transcarbamoylase
… three classes, class A, B, and C, based on their molecular weight, holoenzyme architecture, and enzyme kinetics. Moraxella bovis is a fastidious organism, the etiologic agent of infectious bovine keratoconjunctivitis (IBK). The M. bovis ATCase was purified and characterized for the first time. It …
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