Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Molecular Glue"”.
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Design of Human Serum Albumin and Adenovirus Conjugation via Catcher/Tag Molecular Glue
… innovative method for employing the Catcher/Tag molecular glue to shield Ad with HSA at a molecular precision level. The incorporation of Catcher/Tag technology provides us with a high degree of flexibility and precision in manipulating the construction process. This strategy circumvents the …
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Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia
… the extensive knowledge on its cytogenetic and molecular biology, ALL treatment remains highly challenging especially after relapse. Conventional chemotherapy has shown significant improvement in overall survival rates of pediatric patients up to 90%, however, treatment failure due to ALL …
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Mechanisms of amino acid sensing by the mTORC1 pathway
… Sestrin2 and CASTOR1, respectively. However, the molecular mechanisms through which these components detect their respective amino acids have been elusive. To understand how Sestrin2 senses leucine and signals its presence to mTORC1, we solved the X-ray crystal structure of Sestrin2 in complex …