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Showing 1 to 3 of 3 for “"Molecular Combing"”.
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The promise and perils of molecular combing
<p>Dynamic Molecular Combing (DMC) is a method of making visible single molecules of DNA. The method stretches the molecules, attaching them to a glass coverslip; labels them with an intercalating dye or fluorescent antibodies; and images the molecules with fluorescent microscopy. After combing, …
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Aufbau nanoskopischer Netzwerke aus DNA und Bindeproteinen
… wurden sowohl das Beladen des Stempels durch Molecular Combing als auch die Übertragung der Moleküle durch Transfer Printing unter den speziellen Bedingungen der Verwendung von DNA-Molekülen vertieft untersucht. Es konnte gezeigt werden, dass es möglich ist, gestreckte DNA-Moleküle …
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ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
Oncogene Induced Senescence (OIS) is a tumor suppressive barrier that blocks cell cycle permanently. OIS results from a robust DNA damage response (DDR) activation due to oncogene-induced hyper-proliferation. By performing a whole genome analysis of DNA replication dynamics occurring upon oncogene …