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Showing 1 to 20 of 75 for “"Molecular Chaperone"”.

  1. The Role of Sacsin as a Molecular Chaperone

    Anderson, JohnThe University of Texas Medical Branch at Galveston2013

    … fold, many proteins require the assistance of molecular chaperones. While substantial gains in our knowledge of the function of general chaperones have been made in the last two decades, the role of molecular chaperones in brain-specific processes is not clearly defined. In this study, we …

    utmb Repository record

  2. Effects and dynamics of the UNC-45B molecular chaperone

    Nicholls, PaulThe University of Texas Medical Branch at Galveston2016

    … of self-folding and assembly. Instead, the molecular chaperones work in a precise network to allow a nascent polypeptide to be protected from aggregation and folded to the precisely native product. The assembly of this myosin into a thick filament can proceed largely from the self-directed …

    utmb Repository record

  3. Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer

    Guo, Wei2016

    … Caenorhabditis elegans UNC-45 acts as a molecular chaperone for myosin. Vertebrate genomes encode two UNC-45 genes: the UNC-45A(a) (general cell isoform) is expressed in many organs, whereas the UNC-45B(b) (striated muscle isoform) is exclusively expressed in striated muscle tissues. Our …

    tdl Repository record

  4. Studies of the UNC-45A Molecular Chaperone Expression in Human Cancer

    Guo, WeiThe University of Texas Medical Branch at Galveston2016

    … Caenorhabditis elegans UNC-45 acts as a molecular chaperone for myosin. Vertebrate genomes encode two UNC-45 genes: the UNC-45A(a) (general cell isoform) is expressed in many organs, whereas the UNC-45B(b) (striated muscle isoform) is exclusively expressed in striated muscle tissues. Our …

    utmb Repository record

  5. The UNC-45 molecular chaperone: Its interactions with myosin and its thermosensing properties

    Bujalowski, PawelThe University of Texas Medical Branch at Galveston2016

    … however for others additional assistance of molecular chaperones is needed. The molecular chaperones are proteins which through interactions with the client proteins, prevent the formation of aggregates and promote the folding process without being present in their final structure. One of the …

    utmb Repository record

  6. Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline

    Bahraminejad, Elmira2019

    … form amorphous aggregates or to facilitate their molecular chaperone activity whereby they stabilize partly unfolded proteins. This thesis (i) examines the sequence and structures of caseins underlying their chaperone ability and fibril-forming propensity; and (ii) explores whether the …

    aus-cath Repository record

  7. Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline

    Bahraminejad, Elmira2019

    … form amorphous aggregates or to facilitate their molecular chaperone activity whereby they stabilize partly unfolded proteins. This thesis (i) examines the sequence and structures of caseins underlying their chaperone ability and fibril-forming propensity; and (ii) explores whether the …

    anu Repository record

  8. Analysis of The Biochemical and Cellular Activities of Substrate Binding By The Molecular Chaperone Hsp110/Sse1

    Garcia, Veronica M, <p>0000-0002-7112-3003</p>2017

    <p>Molecular chaperones ensure protein quality during protein synthesis, delivery, damage repair, and degradation. The ubiquitous and highly conserved molecular chaperone 70-kDa heat-shock proteins (Hsp70s) are essential in maintaining protein homeostasis by cycling through high and low affinity …

    uthsc Repository record

  9. Mechanisms of Molecular Chaperone Surface Binding and Endocytosis: Insights into the Molecular Basis for GRP94 Immune Function

    Jockheck-Clark, Angela Roberta2010

    <p>Extracellular GRP94 can elicit both innate and adaptive immune responses by interacting with endocytic and signaling receptors on professional antigen presenting cells (pAPCs). CD91 was the first receptor proposed to facilitate GRP94-mediated immune responses. Using a GRP94 affinity matrix, a …

    duke Repository record

  10. The development of a molecular chaperone-based system to improve the heterologous production of Plasmodium falciparum AdoMetDC protein in E. coli.

    Makhoba, Xolani Henry2011

    … of target recombinant malaria proteins with molecular chaperones of malarial origin in Escherichia coli could improve the yield of the target recombinant proteins. A cytosolic heat shock protein 70 (Hsp70) from Plasmodium falciparum (PfHsp70-1), has been previously shown to exhibit chaperone …

    zulu Repository record

  11. The Role of UNC-45 in Heart Development and Human Breast Cancer

    Chen, DaisiThe University of Texas Medical Branch at Galveston2016

    The C. elegans UNC-45 has been demonstrated as a molecular chaperone of body-wall muscle myosins. In human and other vertebrates, two UNC-45 genes code two UNC-45 protein isoforms: UNC-45A/a and UNC-45B/b. UNC-45A/a is expressed in all cell types, whereas UNC-45B/b only exists in heart and skeletal …

    utmb Repository record

  12. The functional analysis of XhLEA3-2 - a LEA_4 from the resurrection plant, Xerophyta humilis

    Dennis, Timothy JamesDepartment of Molecular and Cell Biology2017

    … to survive drought needs to be studied on a molecular level if it is to be implemented in transgenic crops. Currently, the molecular mechanisms of desiccation tolerance are only somewhat understood, and considerable investigation is still required. Xerophyta humilis is a monocotyledonous …

    cape-town Repository record

  13. Exploring the Mitigation of TDP-43 Toxicity by Sis1 in Yeast

    Ham, JacquelineUniversity of Nevada, Reno2016

    … is that these aggregates are titrating away a molecular chaperone protein, Sis1, from the nucleus of the cell. Sis1 is important in the degradation of proteins, and without it, the cell would become non-viable. In order to examine the relationship between the two proteins, they were tagged with …

    unr Repository record

  14. ANALYZING THE FUNCTIONS OF PREFOLDIN COMPLEX IN NEUROBLAST HOMEOSTASIS OF DROSOPHILA MELANOGASTER

    ZHANG YINGJIE2017

    Prefoldin is a molecular chaperone that regulates tubulin function in mitosis. In this thesis, I show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Co-depletion of Prefoldin and Partner of Inscuteable (Pins) …

    nus Repository record

  15. Structural Investigations of Nematode Anhydrobiotic and Rab11-FIP Proteins by Far-UV Circular Dichroism and Mid-IR Fourier Transform Infra-Red Spectroscopy

    Lall, PatrickNational University of Ireland Maynooth2009

    … the conclusion that this protein functions as a molecular chaperone to relieve oxidative and/or heat stress, similar to current opinions on the functionality of the human homolog.[1] The Rab11-FIP3 homo-dimer predicted coiled coil protein fragment was confirmed by CD spectroscopy and TFE …

    maynooth Repository record

  16. Hsp90 as a molecular target

    Munje, ChinmayUniversity of Central Lancashire2011

    Heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, has been proposed to play a vital role in tumorigenesis. Hsp90 has two isoforms, of which Hsp90α is the major isoform of the Hsp90 complex and has an inducible expression profile. The molecular chaperone Hsp90α has been …

    cent-lancashire Repository record

  17. The development of a flow cytometric method to detect the presence of mutated nucleophosmin in Acute Myeloid Leukaemia

    Du Pisani, Louis AlmeroDivision of Clinical Haematology2014

    … seem to disrupt it normal physiologic role as a molecular chaperone, which likely leads to its oncogenic potential.NPM1 if present alone (not associated with FLT3 internal tandem duplications (FLT3-ITD)) is associated with significantly better overall survival and disease free survival in AML and …

    cape-town Repository record

  18. Development of high-throughput screening assays to identify small molecule inhibitors of Plasmodium falciparum Hsp70-1

    Ncube, Hlomphani Rachel2024

    … shock proteins (Hsps) are a special class of molecular chaperones essential for parasite survival and development within the human host. Hsps are also implicated in drug resistance. Hsp70 forms an integral part of the molecular chaperone system, participating in essential processes such as …

    venda Repository record

  19. The interplay between pathogenic bacteria and bacteriophage Chi: New directions in motility and phage-host interactions in Enterobacterales

    Esteves, Nathaniel C.Virginia Tech2024

    … to proceed. We additionally found that the host molecular chaperone trigger factor is important for the χ phage lifecycle. In Chapter III, we outline our characterization of the initial binding interaction between χ and the flagellum, determining that of flagellin's seven domains, C-terminal …

    vt Repository record

  20. BIOINFORMATIC ANALYSIS OF A MAMMALIAN BIP GENE FOR INSERTION INTO GREEN ALGAE AND COMPARISON OF ITS POSSIBLE EFFECTS ON THE SYNTHESIS OF A MAMMALIAN ANTIBODY

    Ghazanfar, Katrina2019

    … bioinformatics to analyze homologues of a molecular chaperone, glucose-regulated protein 78 (grp 78), also known as BiP. The selected homologous proteins originate from organisms of infinitely diverse genera. Comparisons of protein sequence yielded the first clues of a common ancestry among …

    vcu Repository record

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