Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Molecular Cell Biology"”.
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Reasoning from experiments to causal models in molecular cell biology
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
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Bifurcation Analysis and Qualitative Optimization of Models in Molecular Cell Biology with Applications to the Circadian Clock
… interaction with its cycling environment. The molecular mechanism underlying this physiological process is a cell-autonomous oscillator comprised of a complex regulatory network of interacting DNA, RNA and proteins that is surprisingly conserved across many different species. It is not a …
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Modeling of nucleation-based stochastic processes in cellular systems
Molecular cell biology has been an intensively studied interdisciplinary field with the rapid development of experimental techniques and fast upgrade of computational hardware and numerical tools. Recent technological developments have led to single-cell experiments which allow us to probe the role …
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Statistical physics and biological information : hydrophobicity patterns in protein design and differential motif finding in DNA
… is regulated is one of the main goals of molecular cell biology. To reach this goal, the recognition and identification of DNA motifs--short patterns in biological sequences--is essential. Common examples of motifs include transcription factor binding sites in promoter regions of …
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Computational Systems Biology Analysis of Cell Reprogramming and Activation Dynamics
In the past two decades, molecular cell biology has transitioned from a traditional descriptive science into a quantitative science that systematically measures cellular dynamics on different levels of genome, transcriptome and proteome. Along with this transition emerges the interdisciplinary …
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Characterization of the Role of R7-RGS Proteins in Mammalian Retina and Vision
… David Cain</p><p>Doctor of Philosophy in Biology and Biomedical Sciences</p><p>Molecular Cell Biology</p><p>Washington University in St. Louis, 2014</p><p>Professor Kendall J. Blumer, Chairperson</p><p>GPCR/G protein signaling is a critical component of neuronal signal transduction and …
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Stochastic Simulation and System Identification of large Signal Transduction Networks in Cells
… in many fields of science, especially in molecular cell biology, where, for example, large signal transduction networks are formed, by which cells transfer and process information, based on the biochemical interactions between signal transduction molecules. Complexity arises from the high …
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Identification of novel target genes for the plasticity-related transcription factor Zif268
… (LTP) are widely investigated as a possible cellular correlate of this phenomenon, as it can be induced quickly to elicit long-lasting modifications. These long-term changes in the activity of neuronal circuits are sustained by an altered pattern of gene expression and protein synthesis. The …
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The regulation of the luteinizing hormone (LH) and the follicle stimulating hormone (FSH) by glucocorticoids and progestins
… in the LβT2 mature mouse pituitary gonadotrope cell line. This in vitro model allowed the effects of MPA and NET on the gonadotropins at a transcriptional, post-transcriptional and secretion level to be tested. This study also investigated the effects of MPA, NET, dexamethasone (DEX, a GR …
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Development of microalgae as a biopharming platform
… project tested the feasibility of creating algal cell packs, a novel immobilised microalgae transient production platform for the expression of recombinant protein. First it had to be established whether the available plant expression vectors could be used for the transfer of genetic material into …
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Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)
… degeneration of normal and/or benign tumor cells. Three pathological phenotypes of fibroblast cells, normal, benign and malignant, are exist within an individual despite they are an identical germ line mutation. The influence of tumor-related genes such as TP53, NK4, and ARF, and the impact …
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Flows inside cells: From natural cytoplasmic streaming to microfluidic systems
… streaming, the persistent flow of fluid inside a cell, induces intracellular transport. This plays a key role in fundamental biological processes. In this thesis, we discuss fluid flows inside cells, from naturally occurring cytoplasmic streaming to experimental techniques for inducing cytoplasmic …
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From proteomics to biotechnology. using the resurrection plant eragrostis nindensis to genetically engineer drought tolerant crops
… such as Eragrostis nindensis to survive complete cellular water deficit provides an attractive model for discovery-based omics to not only understand the mechanisms involved in driving desiccation tolerance but to explore the feasibility of potential target genes for orphan crop improvement. The …
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Comparative metabolomic profiling of phenolics in the desiccation-tolerant “resurrection plant” Myrothamnus flabellifolia (Myrothamnaceae) using conventional and green chemistry-based solvent systems
… to an air-dry state, tolerating up to 95% cellular water loss for a prolonged period of time followed by the rapid recovery of metabolism in the tissues within 24–72 h of rehydration. Prolonged cellular water loss is deleterious and is associated with the production of reactive oxygen …