Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Molecular, Cellular, and Tissue Engineering"”.
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Development and Characterization of an Autologous Whole Cell Breast Cancer Vaccine
… due to metastases, rather than the primary tumor and majority of metastases are due to the recurrence and progression of non-metastatic disease. Current adjuvant treatments, such as chemotherapy and radiation, have severe side effects and may result in overtreatment and drug resistance. </p> …
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Nano-Mechanics of Cartilage Glycosaminoglycans Using Molecular Dynamics Methods
… material in synovial joints {Hamerman, 1962} and degeneration of AC can cause pain in the form of arthritis. Current work is centered on the method of replacing damaged cartilage inside the body (in vivo) with tissue engineered outside the body (ex vivo) {Temenoff, 2000}. In order to engineer …
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Structure and Property of Polymers and Biopolymers from Molecular Dynamic Simulations
<p>Natural and synthetic polymers and biopolymers have been studied for a variety of applications in food emulsion, biopharmaceutical purification, tissue engineering, and biosensor. The structure and property of polymers and biopolymers are critically important to determine their functions. …
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Development and Optimization of Imaging and Image Quantification Techniques for Tissue-Engineered Blood Vessel Mimics
<p>Blood vessels mimics (BVMs) are tissue-engineered blood vessels used to test vascular devices in an environment that mimics some simple anatomical factors of native blood vessels. It is important to accurately and consistently assess tissue-engineered blood vessels, although there is currently a …
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Development of a Cell Depositing System Using Inkjet Technology
In the past decade, advances in tissue engineering have allowed researchers to fabricate simple tissues. However, the process of creating these native tissues is a time consuming and inefficient process. A scaffold must first be fabricated then exposed to a sea of cells in the hopes of seeding. …
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Studying the Efficacy of an Injectable 3-Dimensional Fibrin Extracellular Matrix to Characterize the Effects of Antitumor Agents on SW620 Cells in a Microfluidic Device
… third most common cancer in the United States and there is currently a lot of research going into new antitumor agents to kill the cancer. One method for replicating the tumor response to a drug in vivo is by creating an in vitro drug testing model to replicate the in vivo condition. This …
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Regression Analysis of Fracture Toughness for Secondary Osteons Located in Human Cortical Bone
An experiment was carried out in order to locate and quantify osteon types within a sample of cortical bone taken from a human tibia. This was done using a microscope-camera assembly and the BioQuant computer software. The results of this were correlated with a previous experiment’s results on …
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Controlled Migration of Retinal Progenitor Cells Within Electro-Chemotactic Fields
… diseases is overwhelmingly attributed to damage and death of retinal photoreceptor cells. Studies in mouse retina have suggested that transplantation of isolated post-natal or stem cell-derived retinal progenitor cells (RPCs) to replace apoptotic or damaged photoreceptors may be a novel approach …
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Development of an In-Vitro Tissue Engineered Blood Vessel Mimic Using Human Large Vessel Cell Sources
Tissue engineering is an emerging field that offers novel and unmatched potential medical therapies and treatments. While the vast aim of tissue engineering endeavors is to provide clinically implantable constructs, secondary applications have been developed to utilize tissue-engineered constructs …
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Tissue Engineering a Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing
<p><em>Tissue Engineering A Blood Vessel Mimic While Monitoring Contamination Through Sterility Assurance Testing</em></p> <p>Navid Djassemi</p> <p>Tissue engineering blood vessel mimics has been proposed as a method to analyze the endothelial cell response to intravascular devices that are used in …
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In Vivo Metabolic and Vascular Response to Hypoxia in Twist Knockdown Murine Breast Cancer
… transitions can lead to increased motility and invasiveness. It has also been linked to metabolic reprogramming and increased metastatic risk. Furthermore, metabolic preferences can increase proliferation, enhance metastatic potential, and influence the site of metastasis. We hypothesize …
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Mitochondrial mRNA Translation is Required for Maintenance of Oxidative Capacity
… chronic heart disease could be mitigated and one approach to accomplish this may be through targeting the mt-mRNA translation system. Purpose: This investigation’s purpose was to characterize disruptions in mt-mRNA translation machinery in multiple forms of cardiomyopathy and to determine …
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Evaluation of Human Umbilical Vein Endothelial Cells in Blood Vessel Mimics Through Changes in Gene Expression and Caspase Activity
<p>Blood vessel mimics (BVMs) are simple tissue engineered blood vessel constructs intended for preclinical testing of vascular devices. This thesis developed and implemented methods to characterize two of these components. The first aim of this thesis investigated the effect of cell culture …
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Development and Characterization of Tissue Engineered Blood Vessel Mimics Under "Diabetic" Conditions
<p>The development of tissue engineered blood vessel mimics for the testing of intravascular devices in vitro has been established in the Cal Poly tissue engineering lab. Due to the prevalence of cardiovascular disease in diabetic patients and minimal accessible studies regarding the interactions …
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Development and Characterization of an In-House Custom Bioreactor for the Cultivation of a Tissue Engineered Blood-Brain Barrier
… for neurological disorders such as Alzheimer’s and Parkinson’s disease begins by understanding what these diseases affect and the consequences of further manifestation. One particular region where these diseases can produce substantial problems is the blood-brain barrier (BBB). The BBB is the …
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Design of Human Serum Albumin and Adenovirus Conjugation via Catcher/Tag Molecular Glue
… has been the ideal cargo delivery mechanism, and its moderate immunological response makes it ideal for in vivo gene therapies since its discovery in 1953. However, the robust immunogenicity of the Ad capsid and low vaccine absorption via mucous membranes and epithelium put a limit on the …
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Investigation of Experimental Variation of Bovine Sphingomyelin as a Novel Ingredient for Ultraviolet Protection
… because it was created to be an analog to BSM and allowed for visualization of sphingomyelin within the cell.</p> <p>Differences in p21 intensities were observed with BSM and FSM showing a reduced p21 intensity compared to the no sphingomyelin case. FSM helped locate sphingomyelin within the …
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Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays
… to have significant connections to both cancer and Alzheimer’s disease. γ-secretase cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane protein whose cleavage may result in the formation of β-amyloid plaques in the brain. Notch-1 and APP …
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