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Showing 1 to 18 of 18 for “"Mole-rats"”.
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Characterisation of Cutaneous Wound Healing Process in Naked Mole Rats
Being the longest-lived rodent, naked mole-rats (NMR; Heterocephalus glaber) are an exceptional model for biogerontological research. However, unlike other rodents, not much is known about their wound healing process. To investigate that, full-thickness wounds were created in the back skin of naked …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
The naked mole-rat (NMR) is a fascinating animal which has unique biological features including eusociality, strict subterranean inhabitation and poikilothermy. It is the longest-living rodent, showing negligible senescence over the majority of its lifespan and high resistance to diseases such as …
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African mole rats as models for regressive evolution of the eye
… aim of this work was to characterize two African mole rate species (Heterocephalus glaber and Bathyergus suillus) and explore their potential use as novel models for evolutionary developmental eye research. To this end, this histological structure of the adult eye, the development of the eye and …
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The Life History of Damaraland Mole-rats Fukomys damarensis: Growth, Ageing and Behaviour
The social mole-rats have often been typecast as extreme examples of mammalian sociality. With their pronounced reproductive skew, status-related contrasts in lifespan and morphology, and the suggestion of a division of labour amongst helpers, mole-rat societies have repeatedly been likened to the …
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The tangled history of olfaction in African mole-rats, Bathyergidae: insights from Olfactory Receptor genes
… to 119 unique OR genes are characterised from 14 mole-rat species. Bathyergidae OR genes are classified using sequence similarity and phylogenetic comparison with more than 50 mammalian OR subgenomes.
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The trend towards sociality in three species of southern African mole-rats (Bathyergidae) : causes and consequences
Three species of southern African mole-rats, possessing a wide range of social organisation were used to investigate the trend towards increasing sociality occurring in species inhabiting increasingly arid environments. The strictly solitary Georychus capensis, the weakly social Cryptomys …
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Pup ontogeny and factors influencing behavioural and morphological variation in naked mole-rats, Heterocephalus glaber (Rodentia, Bathyergidae)
… study was undertaken on laboratory-reared naked mole-rats. The main objective of the study was to provide a detailed qualitative and quantitative description of the behavioural and morphological development of naked mole-rats from birth through to adulthood. This study laid an empirical …
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Functional anatomy, osteogenesis and bone microstructure of the appendicular system of African mole-rats (Rodentia: Ctenohystrica: Bathyergidae)
… aspects, the skeletal system of African mole-rats (Bathyergidae) has been relatively understudied. Only a few studies have assessed their skeletal system, but these have mostly focused on their cranial and dental systems, with little attention on their postcranial skeleton. This PhD …
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The gonadotropin-releasing hormone (GnRH) system: a comparison between breeding and non-breeding naked mole rats (Heterocephalus glaber)
… and without it, reproduction cannot occur. Naked mole rats (Heterocephalus glaber) have a rigid social hierarchy. The "queen" is the most dominant female and is the only female who breeds. All aspects of reproduction are suppressed in other females in the colony: these "subordinates" are in a …
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Sociality in African mole-rats : exploring how rainfall affects dispersal and genetic exchange in the Natal mole-rat (Cryptomys hottentotus natalensis)
The Natal mole-rat (Cryptomys hottentotus natalensis) is a social subspecies of African mole-rat related to the common mole-rat (Cryptomys hottentotus hottentotus). They inhabit mesic grassland in eastern South Africa from coastal regions to well over 2000m elevation. There have been a few studies …
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Social suppression of reproduction in the naked mole-rat, Heterocephalus glaber : -Plasma LH concentrations and differential pituitary responsiveness to exogenous GnRH
The naked mole-rat provides possibly the most extreme example of socially-induced reproductive suppression observed in any mammal. The majority of colony members remain reproductively suppressed for their entire lives, nevertheless they are not sterile, and can become reproductively active soon …
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Hormonal aspects of reproductive suppression in the naked mole-rat, Heterocephalus glaber
Subordinate, female naked mole-rats (Heterocephalus g/aber) are anovulatory as a result of extremely low luteinising hormone (LH) levels. Evidence suggests that aggression from the dominant female naked mole-rat directed towards subordinates could produce these lowered levels of LH. This study …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… model rodent clades: mice species and African mole-rats, this research offers insights into the molecular drivers of evolution and disease susceptibility across different evolutionary timescales. In the first part of the thesis, I present a project I worked on as part of the Liver Cancer …
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Sociality in the common mole-rat, Cryptomys hottentotus hottentotus : the effects of aridity
… and maintenance of sociality in the African mole-rats. Specifically, the common mole-rat was used as a model to assess the Aridity Food-Distribution Hypothesis (AFDH), as an explanation for the evolution of bathyergid sociality. The AFDH correlates mole-rat sociality with habitat aridity and …
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Synapsid Burrows in the Lower Jurassic Navajo Sandstone, Utah
… groups similar to modern vole (social) and mole rats (eusocial), and likely represent permanent dwelling structures for foraging, nesting, hiding, and food storage. Type II burrows are mega diameter with simple, inclined tunnels ~ 35 cm wide and ~ 20 cm high, and exhibit well-preserved …
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Mechanisms Underlying Mesenchymal Stem Cell-Derived Extracellular Vesicle Modulation of Sensory Neuron Excitability
… (EVs), which facilitate the transfer of biomolecular cargo between cells. Our previous work demonstrated that MSC-EVs alleviate pain in a murine model of OA by reducing OA-induced sensory neuron hyperexcitability, rather than altering joint pathology. These findings underscore the …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… is thus considerable interest in elucidating the molecular mechanisms underlying inflammatory pain. Animal studies represent a valuable tool for studying the complexities of inflammation, which involves a concert of cell types. However, the interplay between changes at the cellular level and the …
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Avian fauna, palaeoenvironments and palaeoecology in the late quaternary of the Western and Southern Cape, South Africa
… avian evidence with that from seals, Cape dune mole rats and steenbok/grysbok suggested that small food items comprised part of a seasonal strategy that made maximum use of a range of seasonal resources. Evidence for significant local environmental change in addition to, and in support of, …