Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Mole-rat"”.
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Understanding the Cancer Resistance Mechanisms of the Naked Mole-Rat
The naked mole-rat (NMR, Heterocephalus glaber) is a highly unusual mammal: eusocial, cold-blooded and with remarkable resistance to hypoxia, hypercapnia and acid-induced pain. Furthermore, NMRs are exceptionally long-lived and extremely cancer resistant. Few studies have attempted to explain the …
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Hormones and cooperative behaviours in the Damaraland mole-rat (Fukomys damarensis)
Large individual differences in cooperative contributions are common within animal societies such as cooperative breeders, where helpers care for offspring which are not their own. Understanding this variation has been a major focus in behavioural ecology and while evidence has shown that …
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Population genetic structuring in the common mole-rat, Cryptomys hottentotus hottentotus
… regimes in two study populations of the common mole-rat Cryptomys hottentotus hottentotus. Aspects relating to the relationship between, gene flow and genetic variation, the roles of mutation and drift in promoting genetic structuring, and the role of genetic parentage in the species' mating …
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DNA Damage Response in Huntington’s Disease and Naked Mole Rat Brain Ageing
This thesis investigates the molecular mechanisms underlying healthy brain ageing in the exceptionally long-lived naked mole rat (NMR) and the role of the DNA damage response in the pathogenesis of Huntington's disease (HD). Multi-omic analyses of NMR brain ageing revealed a lack of a canonical …
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Hormonal aspects of reproductive suppression in the naked mole-rat, Heterocephalus glaber
Subordinate, female naked mole-rats (Heterocephalus g/aber) are anovulatory as a result of extremely low luteinising hormone (LH) levels. Evidence suggests that aggression from the dominant female naked mole-rat directed towards subordinates could produce these lowered levels of LH. This study …
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Sociality in the common mole-rat, Cryptomys hottentotus hottentotus : the effects of aridity
… and maintenance of sociality in the African mole-rats. Specifically, the common mole-rat was used as a model to assess the Aridity Food-Distribution Hypothesis (AFDH), as an explanation for the evolution of bathyergid sociality. The AFDH correlates mole-rat sociality with habitat aridity and …
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Sociality in African mole-rats : exploring how rainfall affects dispersal and genetic exchange in the Natal mole-rat (Cryptomys hottentotus natalensis)
The Natal mole-rat (Cryptomys hottentotus natalensis) is a social subspecies of African mole-rat related to the common mole-rat (Cryptomys hottentotus hottentotus). They inhabit mesic grassland in eastern South Africa from coastal regions to well over 2000m elevation. There have been a few studies …
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Social suppression of reproduction in the naked mole-rat, Heterocephalus glaber : -Plasma LH concentrations and differential pituitary responsiveness to exogenous GnRH
The naked mole-rat provides possibly the most extreme example of socially-induced reproductive suppression observed in any mammal. The majority of colony members remain reproductively suppressed for their entire lives, nevertheless they are not sterile, and can become reproductively active soon …
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The Life History of Damaraland Mole-rats Fukomys damarensis: Growth, Ageing and Behaviour
The social mole-rats have often been typecast as extreme examples of mammalian sociality. With their pronounced reproductive skew, status-related contrasts in lifespan and morphology, and the suggestion of a division of labour amongst helpers, mole-rat societies have repeatedly been likened to the …
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The trend towards sociality in three species of southern African mole-rats (Bathyergidae) : causes and consequences
Three species of southern African mole-rats, possessing a wide range of social organisation were used to investigate the trend towards increasing sociality occurring in species inhabiting increasingly arid environments. The strictly solitary Georychus capensis, the weakly social Cryptomys …
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The tangled history of olfaction in African mole-rats, Bathyergidae: insights from Olfactory Receptor genes
… to 119 unique OR genes are characterised from 14 mole-rat species. Bathyergidae OR genes are classified using sequence similarity and phylogenetic comparison with more than 50 mammalian OR subgenomes.
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Role of High Molecular Weight Hyaluronan in Ultraviolet B Light-Induced Transformation
Keratinocyte carcinomas (KCs) are the most common cancers globally. Ultraviolet light is the key risk factor for these cancers but sunscreen has proven ineffective in their prevention, indicating a need for new prophylactic agents. Chronic elevation of high molecular weight (HMW) tissue hyaluronan …
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The gonadotropin-releasing hormone (GnRH) system: a comparison between breeding and non-breeding naked mole rats (Heterocephalus glaber)
… is the hypophyseal-portal system found in vertebrates, and one of the functions of this system is to mediate reproduction. Mammalian reproduction is controlled by a hormonal cascade which begins in distinct brain regions, namely the hypothalamus and the pituitary gland. Gonadotropin-releasing …
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Profiling extracellular vesicles signatures and deiminated protein cargo across phylogeny and pilot assessment of in vitro application of EVs in tissue regeneration, with focus on selected taxa displaying unusual immunological properties.
… a hypoxia-resistant species, such as the naked mole-rat, identifies pathways linking the brain citrullinome alterations to changes in circulatory EV profiles. Moreover, the thesis explores the regenerative potential of EVs derived from Atlantic cod mucus and serum. Proteomic analysis of …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… model rodent clades: mice species and African mole-rats, this research offers insights into the molecular drivers of evolution and disease susceptibility across different evolutionary timescales. In the first part of the thesis, I present a project I worked on as part of the Liver Cancer …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… essential for cancer cell survival and proliferation. The unique behaviours, phenotypic and molecular adaptations found in the naked-mole rat (NMR) suggest a high stability and effective functioning of the molecular machinery that counteracts damage accumulation in its genome. NMR can reach 32 …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… essential for cancer cell survival and proliferation. The unique behaviours, phenotypic and molecular adaptations found in the naked-mole rat (NMR) suggest a high stability and effective functioning of the molecular machinery that counteracts damage accumulation in its genome. NMR can reach 32 …
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Molecular detection and characterization of Bartonella in small mammals from southern Africa
… Gerbilliscus and Rhabdomys and one subterranean mole-rat species (Bathyergus suillus). The latter was sampled in close proximity to an informal human settlement, whereas the afore-mentioned murid rodent genera were sampled across a range of landscapes inclusive of natural, agricultural, urban, …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
The naked mole-rat (NMR) is a fascinating animal which has unique biological features including eusociality, strict subterranean inhabitation and poikilothermy. It is the longest-living rodent, showing negligible senescence over the majority of its lifespan and high resistance to diseases such as …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… is thus considerable interest in elucidating the molecular mechanisms underlying inflammatory pain. Animal studies represent a valuable tool for studying the complexities of inflammation, which involves a concert of cell types. However, the interplay between changes at the cellular level and the …
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