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Showing 1 to 1 of 1 for “"Moiramide B"”.
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Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B
… dual-ligand molecules. The natural product moiramide B is a broad spectrum antibiotic that inhibits the carboxyltransferase component of acetyl-CoA carboxylase. A crystal structure of moiramide B was solved in complex with carboxyltransferase. The structure shows that only the (S)-methyl …