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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Modular synthesis"”.
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Modular synthesis for cooperative small molecule ligands and chemical education
Modular synthesis can be leveraged as both a synthetic strategy for accessing cooperatively binding small molecule ligands as well as a pedagogic framework for chemical education. Mimicking hemoglobin’s cooperative binding to oxygen stands as an unclimbed mountain in the field of protein mimicry …
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Modular synthesis-enabled mechanistic characterization of the potent antilipoperoxidant activity of peridinin
… of extreme oxidative stress. Enabled by a modular building-block synthetic platform, the structurally atypical carotenoid peridinin was found to be a potent inhibitor of non-enzymatic bilayer lipid peroxidation. With the goal of maximizing the utility of peridinin as a small molecule probe …
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Modular Synthesis and Hydroalkylation of Vicinally Functionalized Ketopiperazines: A solution to the Piperazine Problem
The stereocontrolled synthesis of functionalized piperazines is of great interest to pharmaceutical companies owing to their multiple biological activities such as antidepressant, antiparasitic, anticancer and antiretroviral. Current methods towards functionalized piperazines include intramolecular …
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Efforts towards the synthesis of fully N-differentiated heparin-like glycosaminoglycans; and, Investigations into the mechanism of inactivation of RTPR by gemcitabine triphosphate
Efforts towards the Synthesis of Fully N-Differentiated Heparin-like Glycosaminoglycans. Heparin-like glycosaminoglycans (HLGAGs) are complex information-carrying biopolymers and are an important component of the coagulation cascade. They have also been implicated in interactions with growth …
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Bipyridine Ligands for use in Polymer-Supported Iridium Catalyzed C-H Borylation
… make a polymer-support linker to use in organic synthesis. Bipyridine ligands, such as 4, 4’-tert-butyl-bipyrine with an iridium precatalyst afford a highly efficient C-H borylation, but studies of polymer-supported bipyridine ligands have not been extensively researched. With an aim to exploring …
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Automated small molecule synthesis for accelerated discovery of photo- and electroactive organic materials
… triplet state manifolds via automated modular synthesis and characterization of only ~1.5% of the theoretical molecular space. This approach yielded a physics-based model for photostability that was validated across diverse test sets and enhanced by modulating triplet-state energies in …
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Design and Application of Probes of Novel Bioactivities
… on 4 methylumbelliferone and fluorescein were synthesised and used in screening experiments against these enzymes. To produce libraries of recombinant proteins molecular biology techniques such as site-directed mutagenesis and error-prone PCR were utilised and Agrobacterium tumefaciens …
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Synthesis and Grafting To of Biomimetic Bottlebrush Polymers
… conformation. In this work, I first develop a modular synthesis to facilitate the production of protein-brush hybrids. I successfully made a range of protein-brush hybrids baring elastin-like polypeptides (ELP) as model proteins by using copper-catalyzed azide-alkyne cycloaddition and newly …
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Applying Trichloroacetimidates to the Synthesis of Benzylic Trichloroacetamides & Functionalized Indoles
… shown to be versatile substrates for the synthesis of C-N bonds through [3,3]-sigmatropic rearrangements. This work explores a similar reaction, the rearrangement of benzylic trichloroacetimidates to access benzylic trichloroacetamides. The benzylic rearrangement was shown to proceed under …
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Modular Construction of Complex-Architected Bottlebrush Block Copolymers and Their Self-Assembly Behaviors
… study of such complex systems. An efficient, modular synthetic route is thus highly desired for Lego-like molecular construction of property-decoupled, individually-tunable target materials. In this thesis, we will highlight the research endeavor in developing a multiblock Janus bottlebrush …
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Efforts toward an enantioselective total synthesis of (–)-oxazolomycin B and simplified chemical probes for proteomics studies; pharmacophore-directed retrosynthesis applied to gracilin A : simplified bioactive derivatives.
… no catalytic enantioselective strategies for the synthesis of the densely functionalized oxazolomycin γ-lactam exist in the literature. We have extended the utility of our previously developed enantioselective nucleophile-catalyzed Michael-proton transfer lactamization organocascade to the …
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Studies Towards the Total Synthesis of Patellazole B
… mechanism of action and has deterred total synthesis efforts. This thesis describes synthetic efforts towards Patellazole B, which exhibits the highest potency of the three main congeners. To fully elucidate the structure and renew interest in the patellazoles as anticancer compounds, we …
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Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides
… to a general platform for small molecule synthesis based on iterative cross-coupling. This synthesis was enabled by the development of a new type of diastereotopic group-selective lactonization and a new directing group for the challenging installation of the mycosamine sugar. This …
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Spiropyrans as color-generating mechanophores
… employed to modify product ratios and in the synthesis of chiral molecules. More direct methods of molecular level manipulation such as scanning tunneling microscopes or single molecule force experiments using atomic force microscopy or optical tweezers are recent developments. However, these …
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Metal-ligand cooperativity in first row transition metals: hydrosilylation catalysis and mechanistic insights
… to the large class of diimine ligands. The modular synthesis of PNpy provides a convenient system to tune the sterics and electron richness of the ligands. Synthesis of several PNpy ligands and the corresponding metal-dihalide complexes are described. Chapter 5 focuses on Co-(PNpy) complexes …
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Transmission+Interference: A New Materialist and Machine-Oriented Approach to Collectively Make-With Noise
… arts practices (see also the re-emergence of modular synthesis). The aim is to unfold an understanding of the creative potential within the movement and flow of noise in machines or systems utilising light and sound. Central to this aim is the discussion around the physical objects at play …
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Preparación estereoselectiva de interesantes líquidos iónicos y carbamatos mediante procesos de resolución cinética y desimetrización enzimática
… V. Luis, V. Gotor, ¿Simple and straightforward synthesis of novel enantiopure ionic liquids via efficient enzymatic resolution of (¿)-2-(1H-imidazol-1-yl)cyclohexanol¿ Tetrahedron Lett. 2007, 48, 5251-5254. N. Ríos-Lombardía, E. Busto, V. Gotor-Fernández, V. Gotor, R. Porcar, E. García-Verdugo, …
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Stereospecific Csp3 cross-coupling for modular polyketide synthesis
… represents a simple strategy for the synthesis of functional molecules that is inherently automatable. However, an important limitation to this platform is an inability to generate Csp3-rich, stereochemically complex molecules due to challenges in the coupling of alkyl groups using …