Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Modified amino acids"”.
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Studies on the transport of metal ions and modified amino acids and peptides into liposomes in response to transmembrane pH gradients
… of molecules such as certain metal ions, modified amino acids and peptides across the membranes of model (liposome) systems in response to transmembrane pH gradients. This net transport arises from the membrane permeable nature of the neutral form of the molecule or ion complex. For …
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Active Insulin Analogs That Do Not Require Refrigeration
… to hydrophobic interactions between nonpolar amino acid residues, molecules of insulin tend to interact with each other and undergo fibrillation to form linear aggregates when partially unfolded. Formation of these insulin fibrils significantly decreases insulin stability and activity, and has …
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Post-translational modifications of methyl-coenzyme m reductase in methanosarcina acetivorans
… contains several unusual post-translationally modified (PTM) amino acids near its active site. Although some of these modifications are widely conserved, others are rarely observed. However, all MCRs characterized to date have at least three post-translationally modified amino acids, suggesting …
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Cyclodextrin Assisted Enantiomeric Recognition of Amino Acid Imides and Toward Synthesis of Dolabellane Diterpenoid B
… synthetic drugs are by nature amides, therefore, amino acid based models for transformation of racemates into optically pure compounds were selected for this study. Formation of self-assembly molecular aggregates of properly modified amino acids was observed with and without the presence of …
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SALICYLALDEHYDE-TAGGED PEPTIDES FOR THE REVERSIBLE-COVALENT ENGAGEMENT OF PROTEIN LYSINE RESIDUES
… of this thesis focuses on the synthesis of SA-modified amino acids and their incorporation into model peptides. Later on, a more straightforward and versatile approach was devised, consisting in the late-stage peptide functionalization with copper-catalyzed azide- alkyne cycloaddition (CuAAC). …
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Towards targeted post-translational modification of endogenous proteins in complex environments
… of as polymers comprising the twenty natural amino acids. However, in actuality, the proteome of a typical cell contains hundreds of different amino acid side chains, brought about by co- and post-translational modifications (PTMs). Depending on the roles of the modified amino acids and the …
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Evolutionary, structural and functional features of cellular signalling networks
… and extracellular signals. Since thousands of modified residues as well as entirely new modification types have recently been discovered in proteins, elucidating their biological functions and identifying the protein components of these PTM systems is a fundamental problem. Chapter 1 gives an …
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Project Synthesis of N Acetyl L Histidine Ethyl Amide and Standard Operating Procedure for Fractional Collector
… leads to the formation of cross links of the amino acids in the proteins and leads to induction of cataracts, photo aging of the skin and in the Photodynamic therapy of tumors.<strong></strong></p> <p>Oxidation of proteins involves significant modification of particular amino acids residues …
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AGEing Peptides: Synthesis and Analysis of Peptides Site-Specifically Modified by Advanced Glycation Endproducts
… Glycation Endproducts (AGEs) are a family of modified amino acids that form when proteins react with sugars and sugar degradation products. AGEs are commonly found in processed food as well as in human organs, where they accumulate in tissue proteins, such as collagen, during the normal …
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Facile protein and amino acid substitution reactions and their characterization using thermal, mechanical and optical techniques
… The first objective was to quantify protein and amino acid substitution reactions. Michael addition reactions were used to modify the amino acids and protein. Amino acids alanine, cysteine, and lysine, and protein ovalbumin (OA) were substituted with different concentrations of ethyl vinyl …