Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Modified Vaccinia Ankara"”.
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Development and Characterization of a Modified Vaccinia Ankara Vaccine Candidate Expressing the SARS-CoV-2 Spike Glycoprotein
… to vaccines and heavy reliance on donations. Modified Vaccinia Virus Ankara (MVA) is a low-cost production vector platform which is suitable in this context. This project falls into a bigger study where our group compared different vector platforms, including MVA. The project serves as a proof …
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An investigation of memory T cell phenotypes in peripheral blood of Chacma baboons after immunisation with candidate HIV-1 vaccines
… have reported that immunisation with recombinant modified vaccinia Ankara (SAAVI MVA-C) or DNA prime and Pr55 Gag virus-like particle (VLP) boost based on HIV-1 subtype C are able to successfully induce vaccine specific responses in Chacma baboons. The aim of the current study was to characterise …
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Effects of Modified Vaccinia Virus Ankara Expressing Mesothelin and the Poxvirus Immunoregulatory A35R gene in the Treatment of Murine Pancreatic Cancer
… Our current research uses an improved Modified Vaccinia Ankara poxvirus that we developed to express mesothelin to the murine immune system to treat pancreatic tumors and create an anti-cancer vaccine. PCR, Flow Cytometry, and Western Blot confirmed virus construction, purity, and …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
… selected was the well characterised poxvirus modified vaccinia Ankara (MVA).
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The development of novel HIV-1 vaccines using modified recombinant BCG
… novel HIV-1 vaccine vectors, such as modified BCG, combined with modified vaccinia Ankara in the context of heterologous prime boost regimes. The tuberculosis vaccine Bacillus Calmette–Guérin (BCG) has a wellestablished safety profile as well as notable adjuvant activity with an …
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Elucidating the Immunogenicity and Protective Immune Response of a Trivalent Vaccine for Sudan Ebola, Marburg, and Lassa Fever Viruses
… and efficacy of a trivalent DNA and modified vaccinia Ankara (MVA)-based vaccine candidate expressing an optimised SUDV glycoprotein (GP), MARV GP, and LASV nucleoprotein (NP) were investigated. I assessed the impact of combining all three antigens in a single vector and the effect of …
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Investigation of particulate HIV-1 Env vaccine candidates using Zera® and SpyTag/SpyCatcher technologies
… expressing Env and a mosaic Gag, followed by modified vaccinia Ankara expressing the same antigens and then boosted twice with coupled VLPs. Encouragingly, gp140-ST displayed on SC-AP205 VLPs was an effective boost to heterologously primed rabbits, leading to induction of autologous Tier 2 …