Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Models, Genetic"”.
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Parsing genetic models
… of computer vision applications for parsing genetic models. Genetic models are a visual illustration often used in the biological sciences literature. These are used to demonstrate how a discovery fits into what is already known about a biological system. A system that determines the …
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Synthesis of Local Thermo-Physical Models Using Genetic Programming
Local thermodynamic models are practical alternatives to computationally expensive rigorous models that involve implicit computational procedures and often complement them to accelerate computation for real-time optimization and control. Human-centered strategies for development of these models are …
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Stochastic regulation of signaling in lymphocytes
… transitions in two biochemical models: genetic toggle switches (GTS) and self/non-self peptide-major histocompatibility complex (MHC) discrimination models. In the GTS model, we introduce dynamical disorder in rate coefficients and study its influences in optimal transition …
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Context-Dependent Function of the Splicing Factor hnRNP L
Based on the number of genes impacted (~95% of humans genes), alternative splicing is one of the most extensively used mechanisms for generating proteomic diversity and cellular complexity. Splicing of pre-mRNAs is carried out by a highly specialized, RNA-based macromolecular enzyme known as the …
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Systematic and combinatorial approaches for metabolic engineering of optimal yeast strains to produce fuels and chemicals
… Due to the limited scope of stoichiometric models, genetic screening was combined with the model-based technique, and this led to identification of three knockout mutants (∆cox9, ∆qcr6, and ∆qcr9) with superlative characteristics for enhancing fermentation of glucose and other hexoses …
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Modeling Alzheimer's Disease Using CRISPR/CAS9 Gene Editing and Induced Pluripotent Stem Cells Reveals Conserved Cellular Mechanisms
… autosomal dominant familial AD (fAD) result from genetic mutations in three key genes: amyloid precursor protein (APP), and two APP processing-related genes (presenilin-1 (PSEN1), and presenilin-2 (PSEN2)), supporting the theory that altered APP metabolism is a central cause of AD. However, which …
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Experiments augmented computational analysis of structural materials: A focus on metallic and biological systems
Over the past few decades, the demand for energy-efficient treatment processes to reduce carbon emissions and the need for high performance materials in advanced engineering applications have posed significant challenges for materials scientists. This research first investigates the influence of …