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Showing 1 to 20 of 36 for “"Model membrane"”.
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Model membrane interactions with ions and peptides at the air/water interface
… importance in the functioning of numerous membrane-mediated biochemical processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Alteration of peptide structure could be a cause of many …
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The Nuclear Magnetic Resonance Study of Lipid Protein Interactions in Model Membrane Systems
… acyl chain order and rate of motion in bilayer membranes. In order to determine the effect of membrane protein upon the state of lipid motion, a variety to deuterium labeled phosphatidylcholines have been synthesized and these have been reconstituted with several membrane proteins and peptides. …
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Characterization of the Interaction of Octapeptin With Bacterial Membranes and Model Membrane Systems
Made available in DSpace on 2014-12-14T04:27:49Z (GMT). No. of bitstreams: 1 8009191.pdf: 6047807 bytes, checksum: 12f8488f6fe19df41fa44e16625d4004 (MD5) Previous issue date: 1979
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Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
… believed that the selectivity for bacteria cell membranes over host cells and the potency between different bacteria strains is derived from the ability of the AMPs to exploit the differences in chemical composition of various organism's membranes. The hypothesis guiding this research states: The …
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Influence of osmotic forces and transbilayer membrane area imbalances on the stability and morphology of model membrane vesicles
… asymmetry on the morphology and stability of model lipid vesicle systems. These forces have been implicated in many diverse biological functions including membrane fusion, maintenance of cellular shape and membrane trafficking. The osmotic stability of these large unilamellar vesicles (LUVs) …
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The role of a Polyphenol from Myrothamnus flabellifolius in the protection of membranes during desiccation-using liposomes as a model membrane system
… protein and lipid ultrastructure responsible for membrane stabilisation leading inevitably to the death of the plant. Some plants known as resurrection plants have evolved with the ability to survive dehydration to less than 2% water content, a property known as desiccation tolerance. Recently a …
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INVESTIGATING PROTEIN - BILAYER COMPLEXES: A STUDY OF LIGAND - RECEPTOR INTERACTIONS AT MODEL MEMBRANE SURFACE BY USING ELECTRONIC ABSORPTION SPECTROSCOPY AND FLUORESCENCE RESONANCE ENERGY TRANSFER.
… design, develop and characterize a colorimetric model membrane (liposome) systems, which can bind with proteins, enzymes, bacteria, virus and other biomolecules. PDA molecules are utilized as a scaffold for the bilayer membrane, and a colorimetric assay is carried out. The holy grail of present …
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Tastant interactions with model membranes
… solution and in solution with liposomes, a model membrane system. The observed changes in T1, values are analysed to determine which regions of the tastants are involved in the interaction with the membrane. In Chapters 4 and 5 an investigation is reported of the interaction of tastants with …
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STRUCTURAL INVESTIGATION OF EXTRACELLULAR VESICLES AND THEIR INTERACTION WITH BIOMIMETIC INTERFACES
… extracellular vesicles (EVs), the nanosized membrane bound vesicles, secreted by all kinds of cells to deliver a physiological cargo and their influence on the cell-mediated communication has been rising as a hot topic. Different EVs, have different characteristics and activities, so their …
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Spatial and temporal control of lipid-membrane morphology induced by sphingomyelinase
… the cellular processes by reorganizing the cell membrane morphology. This thesis aims at a more comprehensive understanding of how sphingomyelinase (SMase) can regulate lipid membrane heterogeneity. We develop corralled model raft membranes in a microfluidic device to study the complex phase …
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Protein Dynamics: Studies of Adenylate Kinase Mutants From Escherichia Coli and Characterization of Adenylate Kinase Isoforms From Murine Cells. Applications of Fluorescence Spectroscopy and Microscopy
… AK1beta-EGFP was mainly localized on the plasma membrane. The diffusion rates of AK1-EGFP and AK1beta-EGFP obtained from FCS measurements suggested that AK1 diffused freely in the cytosol of the cell, while AK1beta was bound to the plasma membrane. It has been suggested that AK1beta interacts …
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Energetics of substrate unfolding by ClpA
… maintenance is small, but it serves as an ideal model for energy-dependent molecular machines. The goal of this work is to describe the energetics of ClpA's interactions with both soluble and membrane-bound protein substrates. Green fluorescent protein modified with an 11-amino acid tag that …
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Quantification of membrane transport rates using optofluidics
The transport of ions and small molecules across membranes is a ubiquitous process in biological systems. Effective studies of membrane transport phenomena require suitable model membrane systems, efficient methods to quantify transport kinetics and a robust theoretical framework to derive …
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Understanding Ultrafast Energy Transfer across the Photosynthetic Membrane of Purple Bacteria with Near-Native Systems
… into a larger antenna network within the membrane environment. Peripheral light-harvesting complex 2 (LH2) surrounds the core light-harvesting complex 1 (LH1), which in turn encircles the reaction center (RC). Energy absorbed by LH2 is transferred to LH1 and then finally the RC, where it …
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Studies of the orientational order and bilayer thickness in biological and model membranes
The hydrocarbon order of a membrane bilayer in the hydrocarbon region is suggested to play a fundamental role in maintaining functional integrity in the biological membrane system, Acholeplasma laidlawii strain B. The hydrocarbon order profile, which can be considered to be linearly related to …
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Development of new tools to study drug-lipid interactions and their application to investigating amphotericin b's association with model cell membranes
… of the antifungal drug amphotericin B (AmB) with model cell membranes was studied and new techniques of measuring this interaction using electrochemical and/or spectroscopic methods were developed. Two model cell membrane systems were used: sterol-free lipid monolayers adsorbed to a Hg electrode …
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Using Fluorescent Probes to Study the Location and Interaction of Disaccharides within Lipid Bilayers
… molecule which does not penetrate into the membrane to offer protection during freezing. Our research aims to investigate other disaccharides with varying hydrophilicity as potential cryoprotectants for hydrated cells. In order to study the effectiveness of certain disaccharides as …
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Development and Validation of a Novel Diffusion Chamber for In Vitro Permeability Testing of Topically Delivered Spray Formulations
… of receiving a direct spray application onto a model membrane for the in vitro evaluation of the diffusion of agents from topical spray formulations. This diffusion chamber, as developed in this investigation was coined the Munt/Dash chamber, was validated using two model drugs, diclofenac …
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Model Systems For Studies At The Plasma Membrane: Investigating Lipid Phase Behavior And Protein-Mediated Membrane Remodeling
The plasma membrane is a multicomponent mixture of lipids and proteins. Functional domains ("lipid rafts") that arise from nonrandom mixing of membrane components are believed to be important in governing the spatial organization of lipids and proteins. Proper compartmentalization of lipids and …
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