Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Mobile elements"”.
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P53 Genes Act to Restrain Mobile Elements
… normal human p53 alleles restrained these mobile elements, but mutant p53 alleles from cancer patients could not. Consistent with these results, we also found patterns of unrestrained retrotransposons in p53-driven human cancers. Together, these observations indicate that ancestral …
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Molecular evolution of primates - featuring mobile elements
Mit mindestens 66 Gattungen und über 350 Spezies ist die Diversität der Ordnung der Primaten eine der größten innerhalb der Säugetiere. Obwohl die phylogenetischen Beziehungen von den Hauptlinien geklärt sind, finden sich innerhalb der Familien immer noch viele ungeklärte und umstrittene Fälle. In …
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The role of mobile elements in recent primate genomes
Mobile elements (MEs), which constitute ~50% of the primate genomes, have contributed to both genome evolution and gene function as demonstrated by ample evidence discovered over the last few decades. The three studies in this thesis aims to provide a better understanding of the evolutionary …
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Epigenetic repression of intronless mobile elements by the HUSH complex
… genome is under constant threat from invasion by mobile genetic elements including transposons and viruses. To defend the genome, cells recognize incoming DNA and limit its transcription through repressive chromatin modifications. The human silencing hub (HUSH) complex transcriptionally represses …
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A comprehensive analysis of recently integrated human LINE-1 mobile elements
Long INterspersed Elements (LINE or L1) have had an enormous influence on human genomic structure, comprising about 20% of the mass of the human genome. In this analysis the most recent L1 insertions in the human genome belonging to L1Hs Ta and preTa subfamilies were examined to further understand …
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The Genome of Vibrio orientalis : A Luminous Bacterium.
… the genes that are in the genome. Genes and mobile elements were compared to other Vibrio species to determine the presence of mobile elements related to important cell functions and adaptive functions that provided evidence related to the environments in which the bacterium is able to adapt …
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Helper phage capsid size redirection by staphylococcal pathogenicity island SaPI1 involves internal scaffolding proteins.
… virulence factors are encoded on staphylococcal mobile genetic elements. Members of the SaPI family of S. aureus mobile elements encode superantigens and are mobilized at high frequency by specific helper bacteriophages. One remarkable feature of helper phage exploitation by SaPIs is remodeling …
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Experimental investigation of the fluid driven carbonation of serpentinites and spinel-peridotites: implications for the carbon and trace element cycle in the forearc region of the mantle wedge
… texture. Partitioning coefficients for fluid mobile elements between carbonates and COH-fluids are established experimentally. The results are applied to carbonated high pressure rocks from the Western European Alps. The volatile composition of experimentally derived fluids is quantified in an …
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Experimental investigation of the fluid driven carbonation of serpentinites and spinel-peridotites: implications for the carbon and trace element cycle in the forearc region of the mantle wedge
… texture. Partitioning coefficients for fluid mobile elements between carbonates and COH-fluids are established experimentally. The results are applied to carbonated high pressure rocks from the Western European Alps. The volatile composition of experimentally derived fluids is quantified in an …
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Annotation of Non-Model Species’ Genomes
… pathways, and response to viral sequences and mobile elements. Characterization of the biogenesis pathways of noncoding RNAs has facilitated the development of RNA interference strategies which are increasingly being used in therapeutics, agriculture, and pest control. The focus of this project …
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Complete computational sequence characterization of mobile element variations in the human genome using meta-personal genome data
… structural variants (SVs) and in particular mobile elements insertions (MEIs). Moreover, almost all these methods can detect only the breakpoints of an occurred SV, sometimes with approximation, and do not provide complete sequences representing the SVs. The main objective of our research is …
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Conjugative transfer and expression of an integrative and conjugative element in Pectobacterium atrosepticum : A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… credited to the almost ubiquitous association to Mobile Genetic Elements, the means of Horizontal Gene Transfer enabling rapid exchange of genetic information between bacterial populations. Integrative and Conjugative Elements (ICEs) are Mobile Genetic Elements (MGEs) that are transferred largely …
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Hypermutation and adaptation of experimentally evolved marine Vibrio bacteria
… environment, where horizontal gene transfer and mobile elements play known, significant roles in bacterial evolution.
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Establishing a Trustworthy First Approximation for Evolutionary Distances
… includes several optional features for removing mobile elements from proteomes, for reducing proteomes to their conserved core, for automatically identifying poor quality proteomes in large inputs, and for explicitly identifying pairs of organisms that have horizontally transferred genes and then …
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A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
The Ty retrotransposons of S. cerevisiae are mobile elements that resemble retroviruses, both in their genetic structures and replication cycles. Ty retrotransposition begins in the nucleus with the transcription of Ty RNA. Following translation of Ty proteins, virus-like particles (VLPs) assemble …
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Alu retrotransposition-mediated genomic variation within the primate order
Retrotransposons are an active family of mobile elements within primate genomes and the Short INterspersed Element (SINE) Alu is the most abundant member. These non-autonomous elements are responsible for introducing genomic diversity on an intra- and inter- species level that is useful in studies …
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Conformational Entropy in PEPCK Catalysis: Dynamic Motions Critical to Function
… concert during the catalytic cycle. One of these mobile elements, termed the omega-loop due to its architecture, acts like a lid that closes over the active site and has been hypothesized to serve multiple functions during the catalytic cycle. Furthermore, the act of opening and closing the lid …
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Comparative genomic approaches for investigating evolution in the microbial and viral populations of the rumen
… flavefaciens genomes, there were several mobile elements and clustered regularly interspaced short palindromic repeat (CRISPR) sequences detected, both of which indicate interactions with bacteriophages. The rumen virome sequences revealed a great deal of diversity in the viral …
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Examination of the nematostella vectensis holobiont by comparative bacterial genomics and metatranscriptomics
… of lateral gene transfer or shared phage or mobile elements among the isolates was observed. Isolate genomes did, however, reveal conserved holobiont specific orthologs within members of the same bacterial population that could be reflective of the ecology of the anemone holobiont; for …
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Fluid-mobile element cycling (halogens, boron, lithium) and sourcing through the Costa Rican convergent margin
… in convergent margins can be traced using fluid-mobile elements such as Cl, Br, I, B, and Li. However, previous studies have often overlooked the forearc. Describing fluid loss from subducting oceanic crust to the forearc is difficult for several reasons including differences in pathways due to …
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