Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"MoA"”.
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Palaeoecology and population demographics of the extinct New Zealand moa (Aves: Dinornithiformes).
… of New Zealand’s megafauna, including the moa (Aves: Dinornithiformes), took place at a time of relative climatic stability, and is thought to be due to over-hunting and habitat destruction. The aim of this thesis, using moa as a case study, is to conduct a detailed examination of a …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… show an incompletely penetrant lethality. moa-1 mutations suppress the<em> apl-1</em>(yn5) lethality at the restrictive temperature. Surprisingly, <em>moa-1</em> is involved in male tail development; the male tail is critical for successful mating. This project focused on studying the …
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The Reciprocal Relationship Among Object Relations, Attention, and Language in a Sample of School-Aged Children
… and OR. The Rorschach Mutuality of Autonomy (MOA) scale (Urist, 1977; Urist & Shill, 1982) and adapted version for the TAT (MOA-TAT) were used to assess OR. Pearson correlation analyses were used to examine the convergence between the MOA and MOA-TAT scales, as well as their relationship to …
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Effektivität der neuen 7-Tage-Tripel-Therapie mit Esomeprazol, Rifabutin und Amoxicillin bei Infektionen mit Makrolid- und Imidazolresistenten Helicobacter pylori Stämmen
… oder der modifizierten Hochdosis-Dualtherapie (mOA – Omeprazol 3 x 40 mg und 3 x 1000 mg Amoxicillin über 14 Tage) behandelt. Die ERA-Therapie wurde von allen Patienten ohne nennenswerte unerwünschte Wirkungen absolviert und sie führte in 30 von 36 Patienten (83.3 %) zur Heilung der chronischen …
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The impact of youth enterprise development fund on the transition of youth to adulthood in Gatanga Sub-County, Kenya
… by Arnett, namely, “Markers of Adulthood” (MoA) and “Inventory of the Dimensions of Emerging Adulthood” (IDEA) scales to assess emerging adulthood related issues to reveal any differences between funded and non-funded youth in Gatanga sub-county. Relevant data were collected using …
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Object Relations in Children's Projective Testing: Applying the Mutuality of Autonomy Scale to the Thematic Apperception Test
… application of the Mutuality of Autonomy Scale (MOA) (Urist, 1977; Urist & Shill, 1982), commonly used as a Rorschach Inkblot Method object relations scale, to examine verbal narratives on the TAT. It was hypothesized that findings from the proposed study would demonstrate that the MOA is a …
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Using biological and chemical information to improve understanding of drug mechanism of action on the systems-level
… of a therapeutic compound’s mechanism of action (MoA) can provide great benefits to the drug discovery process. Biological and chemical information e.g., transcriptomics data is increasingly becoming easier to measure by high throughput methods, and large amounts of this type of data are available …
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Identification of determinants of sensitivity to duocarmycin analogues: A class of potent anti-cancer drugs
… of cancer. Although the mechanism of action (MOA) of duocarmycins has been elucidated as DNA minor groove alkylation, not much is known about the factors involved in the intrinsic sensitivity of cancer cells to duocarmycins. This thesis aims to identify the determinants of sensitivity of …
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Physical, genetic, and biochemical analyses of mannityl opine catabolism genes from the Agrobacterium Ti plasmid pTi15955
… for catabolism of MOP and mannopinic acid (MOA) are encoded by a 16.4 kb region, whereas those for AGR are encoded by a 9.4 kb region located within the MOP catabolic locus. The induction pattern of catabolism shown by transposon insertion derivatives suggests that catabolism of MOP, AGR and …
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Use of Fluridone for Control of Palmer Amaranth (Amaranthus palmeri) in Cotton (Gossypium hirsutum) and on Ditchbanks
… and is unique in that its mechanism of action (MOA) is not currently registered for use in cotton. Studies were conducted to determine the length of residual that fluridone provides in controlling Palmer amaranth in Arkansas glyphosate- and glufosinate-resistant cotton programs and along field …
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Using Heterogeneous Information Sources for Understanding and Predicting Biological Effects of Compounds
… effects such as its Mechanism of Action (MoA) and safety profile is a challenging task in drug discovery process. However, this understanding can facilitate drug discovery process and provide an early warning for potential risks. Biological effects understanding has been significantly …
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In Silico Classification of Industrial Chemicals Associated with Acute Aquatic Toxic Action Utilising Molecular Initiating Events
… non-testing methods towards Mode of Action (MOA) determination as an important part of understanding toxicity to aquatic organisms. However, current MOA classification approaches for acute aquatic toxicity endpoints are limited by their chemical and mechanistic domains. This thesis developed …
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RACE-Seq identifies the Argonaute-2 cleavage products of RNA interference-based oligonucleotides
… peak profiles, an on-target mechanism of action (MOA) for up to four active siRNA derived from siRNA19 is proposed. The shRNA19 RACE-Seq assay predicted that this hairpin molecule probably exists as two distinct forms, one with a 7-nucleotide loop and the other with a 5-nucleotide loop. The …
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Synthesis of FtsZ inhibitors : potential antibiotic agents
… also aimed to explore the mechanism of action (MOA), toxicity profile and resistance potential of 11. It was found that 11 did not inhibit FtsZ; however, S. aureus could not develop resistance to the compound. Although the goal of developing a FtsZ inhibitor was not accomplished, the inability …
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A partnership of peoples : understanding collaboration at the Museum of Anthropology
… project underway at the Museum of Anthropology (MOA) at the University of British Columbia (UBC), designed to facilitate collaborative research at the museum. It also serves as a case study for my consideration of the relationship between museums and the visiting public as a part of the …
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Proteolysis-targeting chimeras as a novel strategy for targeting epigenetic mechanisms in Plasmodium falciparum parasites
… novel drugs with novel modes-of-action (MoA) are needed. Current antimalarial efforts aim to identify small-molecule inhibitors that bind to the active site of essential target proteins, thereby killing the causative organism, Plasmodium falciparum. However, such active site-dependent …
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Discovery of Alternative Artemisinin Binding Sites in Plasmodium falciparum ATPase-6
… there are multiple suggested modes of action (MOA) for artemisinin, none to date have a well-characterized protein target except for PfATP6, proposed by Krishna, et al. His work suggested that artemisinin binds to the homologous thapsigargin binding site of PfATP6. Herein, knowledge of the …
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Synthesis, Chemistry, Biological Evaluation And Structure-Activity Relationships Of Rac- And Chiral 6-Desmethyl-5Β –Hydroxy-D-Secoartemisinin And Analogs
… This is logical as the mechanism of action (MOA) of artemisinin and related 1,2,4-trioxanes appears to be related to protein binding folloby a Fe(II)-mediated C4 radical hypothesized to react covalently with a plasmodial SERCA cysteine moiety, blocking the SERCA Ca-channel. This radical is …
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Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity
… of compounds with novel mechanisms of action (MoA), dual-stage activity, and with immutable targets. Until now, drug discovery has typically focused on the development of antimalarials that are entirely organic in composition. This has left the field of inorganic medicinal chemistry and …
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TOWARDS UNDERSTANDING MODE-OF-ACTION OF TRADITIONAL MEDICINES BY USING IN SILICO TARGET PREDICTION
… but in many cases their modes-of-action (MOAs) remain unclear. Given the increasing data of chemical ingredients of traditional medicines and the availability of large-scale bioactivity data linking chemical structures to activities against protein targets, we are now in a position to …
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