Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Mnk1"”.
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… factors. Map Kinase Integrating Kinase 1 (Mnk1) relays signals to its major downstream target eIF4E. Activation of Mnk1 and subsequent phosphorylation of eIF4E results in changes in translation rates for subsets of mRNAs. Both the Erk1/2 and p38 MAPK pathways activate Mnk1 meaning that Mnk1 …
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Assessing eIF4E-S209 Signaling and Translationally Regulated Mechanisms in Neurodegeneration
… serine/threonine kinases (MNKs) 1 and 2. MNK1 or 2 then phosphorylate eIF4E, at a specific residue; serine 209 (S209). Phosphorylation of eIF4E-S209 by the MNKs can alter the subsets of mRNAs translated in response to stimuli that activate MAPKs. Differential translation induced by …
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TNFalpha expression in monocytes/macrophages
… and translation of the transcripts. The kinase Mnk1, activated by ERK and/or p38, phosphorylates the translation initiation factor eIF4E and this correlates with TNF production. A proposed signalling pathway to translational regulation of TNF in mouse macrophages is presented.
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The role of cellular signalling pathways and translation initiation factors in Herpesvirus infection
… activities of the down stream substrate of ERK, Mnk1, along with the mTORC1 substrate 4E-BP, both of which regulate the mRNA translation initiation factor eIF4E were shown to be required for efficient reactivation. To further investigate the role of translation initiation during reactivation, we …
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Caractérisation des facteurs de transcription impliqués dans l'expression génique de cytokines chez les neutrophiles humains
… nous avons documenté l'activation de la kinase MNK1 par la MAPK p38, et son rôle dans la régulation traductionnelle des cytokines. L'ensemble de ces travaux a permis d'identifier des molécules-clés dans la génération de cytokines, plus particulièrement de chimiokines, chez le neutrophile humain. …