Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Mlh1-Pms1"”.
-
Investigating DNA remodeling in DNA mismatch repair
… clamp (PCNA)-stimulated endonuclease Mlh1-Pms1/PMS2 (yeast/human), which nicks the DNA distal to the mismatch location and a pre-existing single strand break, that may allow the pathway to distinguish between DNA strands. The Mlh1-Pms1/PMS2-generated nick allows downstream proteins to …
-
Visualizing the One-Dimensional Diffusion of DNA Mismatch Repair Proteins at the Single-Molecule Level
… along DNA by the protein complexes Msh2-Msh6 and Mlh1-Pms1 in order to locate and remove mispaired bases. The details of these critical processes remain poorly understood, largely due to a lack of experimental methods capable of probing these dynamic processes. A custom total internal reflection …
-
New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… interacts with the mismatch repair (MMR) protein MLH1, which, together with MLH3, is indispensable for CAG repeat expansion in HD. Here, I show that FAN1 interacts with MLH1 via a well conserved MLH1- interacting peptide motif (MIP-box) on FAN1, which is necessary for FAN1-MLH1 interaction. I …