Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 57 for “"Mixed Ancestry"”.
-
Investigating local ancestry inference models in mixed ancestry individual genomes
… populations, leading to admixture. Known admixed populations include the mixed ancestry of South Africa, Latin Americans and African Americans. Admixed individuals play important roles in understanding population history, disease aetiology, and personal genomics. Accordingly, efforts have …
-
Growth Analysis of Mixed Ancestry Infants Aged 0 – 18 months, South Africa
… later in life. In South Africa, children of mixed ancestry (MA, 1-10 years) have a significantly higher risk for stunting (according to WHO growth standards) compared to other population groups. Adults of MA have the second highest type II diabetes mellitus prevalence, and hypertension …
-
An investigation into the experiences of mixed ancestry parents with a preschool child with down syndrome
… disability and in the South African (SA) mixed ancestry population a prevalence of 1.54 in 1000 live births have been reported. Children with DS have a unique variety of health concerns and therefore regularly need to be followed-up. In the Western Cape (WC), the Red Cross War Memorial …
-
Temporal changes in the cardiometabolic disease risk profile of the Bellville south mixed-ancestry community between 2008/09 AND 2014/16
… including South Africa. In the South African Mixed-ancestry population, there is a dearth of trend studies examining the changes in cardiometabolic risk factors and their behavioural, socio-demographic, and lifestyle determinants. This thesis aimed to determine the temporal changes between …
-
Elucidating the genetic aetiology of Bipolar Disorder
… Test (FBAT) of 621 individuals of Caucasian and Mixed Ancestry families from South Africa. This was followed by whole-exome sequencing (WES) of eight members of an Afrikaner family to identify rare, coding variation. These two approaches were used to identify both common and rare variation which …
-
The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
… in CYP2C9 and VKORC1 amongst black and mixed ancestry South Africans and clinical surrogates of warfarin metabolism. Medical records were accessed to determine time to INR and warfarin doses. DNA was extracted from blood samples, and genotyping for polymorphism in CYP2C9 (*2,*3,*8,*11) …
-
Stature estimation: evaluating regression equations for different population groups in South Africa
… total skeletal height of South Africans of Mixed Ancestry was investigated as no population-specific standards exist for this group. Additionally, the reliability of the generic femur/stature ratio (Feldesman et al., 1990) to estimate living stature for all three population groups was …
-
A descriptive study of IgG subclasses and allotypes in children with pulmonary tuberculosis in the Western Cape
… tuberculosis positive, 15 of which were of Mixed and 20 were of Black Ancestry. CONTROL GROUP: Sera were selected from 224 Black Ancestry (59 children and 165 adults) and 211 Mixed Ancestry (67 children and 144 adults) that had no evidence for active tuberculosis or a history of previous TB …
-
Detailed investigation of the unstable (CAG) repeat and the immediate surrounding region of the IT15 gene in some South African families with Huntington disease
… families were comprised of seven Caucasian, 6 Mixed Ancestry and two Black African families.
-
Identification of genetic polymorphisms associated with oesophageal squamous cell carcinoma risk in South Africa
… occurring with high incidence in the Black and Mixed Ancestry populations. Previous studies by our research group have reported that genetic polymorphism of xenobiotic metabolizing enzymes influence greatly the detoxification of tobacco-related carcinogens in vivo, and may therefore have an …
-
The assessment of molecular markers for skin colour determination in the South African population
… identified as potentially problematic within mixed ancestry populations. This will be done through designing and analysing a multiplex SNaPshot genotyping assay and independent pigmentation measurements.
-
Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population
… were found in African blacks and individuals of mixed ancestry, while subtypes A1 and A4 are found only in whites and individuals of mixed ancestry. Subtype A5 was associated with >10 KS lesions at presentation in the AIDS-cohort (32/38, p=0,050), but not in the African endemic patients (2/4, …
-
Identification of a suitable SNP for allele-specific silencing of the disease-causing gene in SCA1 patients in South Africa
… a 1997 report of two founder haplotypes in the Mixed Ancestry SCA1 families in the Western Cape of South Africa, using microsatellites. The aim was to narrow the region investigated in the previous study, and confirm the existence of founder haplotypes using a SNP-based haplotype. The SNPbased …
-
Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
… for warfarin dosing among black Africans and the Mixed Ancestry population group in Southern Africa. Method: A total of 302 black Africans and 277 Mixed Ancestry adults undergoing warfarin treatment were recruited at INR clinics in the Western Cape Province, South Africa and Harare, Zimbabwe. …
-
Targeted re-sequencing of a large South African cardiomyopathy cohort
… recruited were Black-African (58%) and Mixed ancestry (33%). We reported a diagnostic yield of 16.9% (76/450) for the DCM probands, where 68.4% of the probands had pathogenic TTN truncating variants. The adult HCM cohort constituted 10.1% (60/594) of the IMHOTEP study probands, with a …
-
Genealogical tracing of founder variants linked to cardiomyopathies in a South African cohort
… BAG3 was linked to French-Huguenot and Canadian ancestry. LMNA tracing was limited due to the number of families as well as limited Mixed-Ancestry family records. TTN variants had issues with haplotyping and genealogical challenges as well as limited records for Black African and Mixed-Ancestry …
-
The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population
… therapy in South African black (SAB) and Mixed Ancestry (MA) participants. Methods: We recruited consenting participants from Groote Schuur Hospital and Gugulethu Community Health Centre comprising 263 of Mixed Ancestry (MA) descent and 109 of South African black (SAB) descent. Demographic …
-
Genetic risk factors for overuse and acute musculoskeletal injuries
… as ACL rupture in a combined cohort of European ancestry (Swedish, South African, Polish and Australian) (Chapter 5) and a South African Mixed Ancestry cohort (Chapter 6) using a case-control genetic association study approach. A secondary aim of the thesis was to investigate hypothesis-driven …
-
A COMPREHENSIVE EXAMINATION OF THE UNIVERSITY OF MONTANA CASE 29
… were analyzed to gain information on the sex, ancestry, age, stature, weight, pathology, and trauma of the individual. This information is helpful in assisting law enforcement personnel or for research purposes. Several different methods used by forensic anthropologists were used to examine …
-
A COMPREHENSIVE EXAMINATION OF THE UNIVERSITY OF MONTANA CASE 29
… were analyzed to gain information on the sex, ancestry, age, stature, weight, pathology, and trauma of the individual. This information is helpful in assisting law enforcement personnel or for research purposes. Several different methods used by forensic anthropologists were used to examine …
Page 1 of 3