Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Mitoxantrone"”.
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THE DESIGN OF A NOVEL ANTI-TUMOUR DRUG DELIVERY SYSTEM USING IMMUNE-DERIVED CELLS.
… phase, or the anticancer drugs doxorubicin or mitoxantrone which located in the lipid bilayer. Unelicited murine peritoneal macrophages were chosen as the mcrophage model for the present study and attempts were made to isolate them from murine peritoneal exudate. The isolation of monocytes …
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Synthesis, DNA interactions and activation of novel cytotoxic anthraquinones.
Mitoxantrone is a dihydroxyanthracenedione derivative with significant clinical activity against advanced breast cancer, lymphoma and several types of leukaemia. However, as with all conventional anticancer agents, its non-specific nature results in dose-limiting systemic toxicity. The …
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Development of a TSM Biosensor for the Determination of DNA- Drug Interactions: A Novel Method to Assist Drug Development
… w ith different modes of binding. These were mitoxantrone. and two other anthraquinones, which exhibit intercalation and surface binding; bisbenzamide that exhibits groo\e binding, and cisplatin that forms cross-links with DNA. Measurement of the resonant frequency of the coated DNA sensors …
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Mass Spectrometric Analysis of Cytoplasmic Ribosomal Proteins in Drug Resistant and Drug Susceptible Human Cell Lines
… were examined. Ribosomes were isolated from mitoxantrone susceptible and mitoxantrone resistant MCF-7 cells. The acid extracted ribosomal proteins were subjected to optimized 2DGE using a "zoom" strip (pI 7-11) for the first dimension separation. Further optimization of 2DGE included the use …
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COMPARATIVE PROTEOMICS STUDIES OF SOLUBLE NUCLEAR PROTEINS OF DRUG SUSCEPTIBLE AND RESISTANT HUMAN BREAST CANCER MCF-7 CELLS
… breast cancer cell lines resistant to etoposide, mitoxantrone, adriamycin in the presence of verapamil by both gel comparisons and isotope labeling. Abundances of cytoskeleton proteins, such as cytokeratin 8, cytokeratin 19, septin 2, and alpha tropomyosin, are altered in common across the three …
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Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
… the cells to treatment with the BCRP substrate mitoxantrone. Combination index calculations suggested synergism between nutlin-3a and mitoxantrone in cell lines over-expressing BCRP. Upon further investigation, it was confirmed that nutlin-3a increased the intracellular accumulation of BCRP …
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Molecular modeling of DNA with minor groove binding agents and intercalators
… AMBER 4.0. Intercalators ethidium, ellipticinc. mitoxantrone, and bisantrene were modeled with an oligonucleotide d(CGCG)~ using SpartanPlus and DOCK 4.0. The binding site was prepared from an x-ray study of this oligonucleotide interacting with ditercalinium, a bis-intercalator. The purpost: of …
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Investigation of anthracycline based topoisomerase II inhibitors in triple negative breast cancer
… primarily relies on chemotherapy for treatment. Mitoxantrone (MTX), a topoisomerase II inhibitor belonging to the anthracenedione class, is used in BCa therapy. This thesis investigates the potential and mechanism of action of the MTX analogue KP71 and two metal organic frameworks (MOFs), UiO-66 …
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Properties and biomedical applications of magnetic nanoparticles
… and triggered the release of an anticancer drug mitoxantrone . We also parameterized the chain length dependence of drug release from dextran coated iron oxide nanoparticles, finding that both the release rate and equilibrium release fraction depend on the molecular mass of the surfactant. …
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Proteomic Analysis of Plasma Membrane Proteins from Drug Susceptible and Drug Resistant Breast Cancer Cell Lines
… identify protein expression changes between the mitoxantrone drug susceptible and drug resistant MCF-7 breast cancer cell lines.
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Optimization of Optical Nanosensor Response for the Detection of Anthracyclines Using a Binary Machine Learning Classifier
… Daunorubicin, Doxorubicin, Epirubicin, Mitoxantrone and Idarubicin, were used to interrogate 12 SWCNT preparations wrapped with separate oligonucleotide sequences. In triplicate, the near-infrared fluorescence responses of each combination of oligonucleotide and anthracycline were …
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Φασματοσκοπικός έλεγχος ενδεχόμενης αποδέσμευσης (νανο)υλικών από βιοπολυμερικές συσκευασίες σε προσομοιωτές τροφίμων
… στις μελέτες των τριών υποστρωμάτων ήταν το Mitoxantrone. Όσον αφορά στα κολλοειδή αιωρήματα, πραγματοποιήθηκε συστηματική μελέτη της επιρροής του παράγοντα συσσωμάτωσης των νανοσωματίδιων Ag και της συνεπακόλουθης εξάρτησης της ενεργότητας SERS από τον ρυθμό αύξησης της υδροδυναμικής ακτίνας …
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PREPARATION OF NANO- AND MOLECULAR COMPOUNDS FOR ANTITUMORAL APPLICATIONS TRIGGERED BY LIGHT
… The antitumoral drug selected in this thesis (mitoxantrone) can be replaced with an organic photosensitizing agent to introduce an additional PDT treatment. In the third project HNT were functionalized in their inner lumen to serve as carriers for hydrophobic photosensitizers, such as …
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Purging e alte dosi di chemioterapia con reinfusione di cellule staminali autologhe in linfomi non Hodgkin follicolari resistenti/refrattari
… 3-4 weeks. The conditioning regimen was based on Mitoxantrone 60mg/mq + Melphalan 180 mg/mq, followed by SC re-infusion 24-hours later and G-CSF starting 24 hours after re-infusion. In 19 pts the SC underwent purging: in 10 harvests the CD34+ were selected by immunomagnetic beads, while in the …
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Silver (I) Complexes as Antimicrobial and Anticancer Drugs
… than the anthracene-containing anticancer drug, Mitoxantrone.
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Formulation Devlopment Of Mesoporous Silica Nanoparticles As An Injectable Delivery System
… loading, release and activity of mitoxantrone (MTX), we synthesized thiol (SH), mixed thiol/amine (SH/NH2) and amine (NH2) functionalized MSN by sol-gel process. We observed that NH2</p> <p>modification of MSN has limited MTX loading. In contrast, modifications of MSN with SH …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… GCDCA-S + cyclosporine A for OAT3, atenolol + mitoxantrone for OCT2) were identified to disentangle overlapping transport and establish selectivity towards OAT2, OAT3, and OCT2. These data provided a practical panel of substrates and substrate-inhibitor pairs that enables uptake …
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Quantitative 31P-MR-Spektroskopie am menschlichen Herzen und Etablierung von SLOOP am Skelettmuskel
Die vorliegende Arbeit setzt sich mit dem Einsatz der 31P-Magnetresonanzspektroskopie (MRS) zur Untersuchung des menschlichen Herz- und Skelettmuskelstoffwechsels auseinander: [1] Mit der Anwendung und Implementierung der akquisitionsgewichteten CSI (AW-CSI) am menschlichen Herzen konnten wir den …
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Σχεδιασμός, σύνθεση και αξιολόγηση πεπτιδικών και μη πεπτιδικών αναλόγων της εκλυτικής ορμόνης των γοναδοτροπινών (Gonadotropin Releasing Hormone, GnRH)
Η εκλυτική ορμόνη των γοναδοτροπινών (GnRH ή LHRH) είναι ένα δεκαπεπτίδιο υπεύθυνο για τον έλεγχο και την απελευθέρωση των γοναδοτροπινών ορμονών LH και FSH και κατ’ επέκταση για τη ρύθμιση της λειτουργίας του αναπαραγωγικού άξονα. Τροποποιημένα πεπτιδικά ανάλογα της GnRH χρησιμοποιούνται για τη …