Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Mitotic catastrophe"”.
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Regulatory Mechanisms of Mitotic Catastrophe Induced by Doxorubicin
… membranes and induce apoptosis, senescence or mitotic catastrophe. Because low dose of doxorubicin induce senescence or mitotic cell death, we attempted to investigate the possible link between the drug-induced senescence and mitotic cell death as comparing with apoptotic cell death induced by …
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Quantitative analysis of signaling networks in proneural glioblastoma
… of CDK₁ Y₁₅. MK-₁₇₇₅ treatment resulted in mitotic catastrophe of these cells, as measured by increased DNA damage, abnormal percentages of cells in cell cycle phases, and death by apoptosis. This response was abrogated by inhibiting CDK₁ with roscovitine, a CDK inhibitor, demonstrating the …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… persistent DNA damage, telomere dysfunction, and mitotic catastrophe. We find that Atrx deleted tumors have impaired cGAS-STING signaling, with accompanying sensitivity to the novel clinical therapy oncolytic herpesvirus. Translation of these results to patients with ATRX mutant cancers could …
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The physiological role of the two isoforms of DNA topoisomerase II in human cells
… topoisomerase IIalpha which bound to the mitotic chromatin with low affinity. Consequently an increased rate of nondisjunction is observed in these cells. It is concluded that high affinity chromatin binding of topoisomerase IIalpha is essential for chromosome condensation/disjunction and …
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Methods to Investigate Hyperthermia Induced By Tumor Treating Fields
… interruption of the spindle structure leading to mitotic catastrophe and the formation of non-viable daughter cells. Tumor Treating fields do not stimulate nerves and muscle because of their high frequency, and do not generate heat because of their low intensity. However, there is no study to …
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Genome-wide CRISPR Screening in FBXW7-mutant Cells Uncovers Multiple Druggable Synthetic Lethal Interactions Involving Cell Cycle Control
… stress and that ATR inhibition will force mitotic entry leading to mitotic catastrophe.
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Identification and Characterization of Potential Novel Targets in Thyroid Carcinoma: Evidence of Non-Oncogene Addiction Unveiling Tumor Cell Vulnerabilities
… tumor cells inhibited cell growth, led to mitotic catastrophe and induced DNA damage and cell death. COPZ1 depletion induced abortive autophagy, endoplasmic reticulum stress and apoptotic cell death in thyroid tumor cells, as well as tumor growth inhibition in vivo. Together, our studies …
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Mathematical Modeling Reveals That G2/M Checkpoint Override
… 1 (mTORC1) plays an essential role to regulate mitotic entry after irradiation. Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… 1 (mTORC1) plays an essential role to regulate mitotic entry after irradiation. Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… 1 (mTORC1) plays an essential role to regulate mitotic entry after irradiation. Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling …
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A Novel Function For Aurora B Kinase In The Regulation of P53 By Phosphorylation
<p>The mitotic kinase Aurora B plays a pivotal role in mitosis and cytokinesis and governs the spindle assembly checkpoint which ensures correct chromosome segregation and normal progression through mitosis. Aurora B is overexpressed in breast and other cancers and may be an important molecular …
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Identification of TICRR, a novel checkpoint and replication regulator
… the S/M checkpoint, leading to premature mitotic entry of cells with partially replicated genomes and mitotic catastrophe. Therefore, Ticrr is a novel cell cycle regulator essential for genomic integrity with roles in replication as well as in the S/M and G2/M checkpoints. We have …
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Anti-candida and Anti-virulence Activity of Essential Oils and Their Components
… cell-cycle checkpoint deficiency, and mitotic catastrophe, which resulted in C. albicans death. At lower fractional MICs, essential oils had a ROS-independent response that inhibited mycelial growth and biofilm formation, which may be attributable to defects at the cell membrane. …
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DISSECTING THE CLINICAL AND BIOLOGICAL RELEVANCE OF DIS3 GENE IN MULTIPLE MYELOMA
… RNA or amino acid metabolism, translation, and mitotic spindle checkpoint. Overall, our comprehensive assessment of the clinical and transcriptional consequences of DIS3 mutations or its deletion in MM strongly indicates that they may play an important role in the mechanisms of transformation …