Global ETD Search
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Showing 1 to 5 of 5 for “"Mitotic Spindle Apparatus"”.
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The evolution of centrosome and chromosome number in newly formed tetraploid human cells
… the cell's microtubule cytoskeleton and mitotic spindle apparatus. Centrosome number homeostasis is crucial for health, and recent studies have shown inducing extra centrosomes in cells can induce tumor formation in mice. This has led some researchers to propose that the extra centrosomes …
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Eukaryotic chromosome segregation: New aspects of separase regulation by securin, Cdk1, PP2A and auto-cleavage
… when all chromosomes interact properly with the mitotic spindle apparatus does the anaphase promoting complex or cyclosome (APC/C), a multisubunit E3 ligase, mediate the ubiquitylation of securin and cyclin B1. Their subsequent proteasomal degradation then releases active separase. Murine …
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The Mitotic Spindle Mediates Inheritance of the Golgi Ribbon Structures
… reforms in both daughter cells after division. Mitotic Golgi membranes concentrate around the spindle poles, suggesting that the spindle may control Golgi partitioning. To test this, cells were induced to divide asymmetrically with the entire spindle segregated into only one daughter cell. A …
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Synthesis and Molecular Pharmacology of the Diazonamides
… determined that the diazonamides are potent antimitotic agents that induce the formation of mono-aster mitotic spindles. The synthesis of numerous analogs established structure activity relationships which guided the preparation of biotinylated, fluorescent, and radiolabeled forms of the natural …
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The peptidyl-prolyl isomerase Pin1 is required for maintenance of the spindle assembly checkpoint
… with its essential co-activator Cdc20. The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the chromosomes' interactions with the microtubules of the mitotic spindle apparatus. In response to even one erroneous attachment the affected kinetochore emits a "wait …