Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Mitotic Exit"”.
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Mitotic Exit: Thresholds and Targets
… (stability, localization, etc.). As cells exit mitosis, the CDK that has driven many of the cell cycle processes is inhibited and degraded, allowing many of the kinase substrates to return to their unphosphorylated state. This assures that each subsequent cell cycle is begun in the same …
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Peak Mitotic Cyclin Permits Mitotic Exit
… complexes promote replication origin firing and mitotic entry, and conversely, inhibit pre-replication origin loading and exit from mitosis. Cyclin synthesis and degradation, Cdk phosphorylation and Cdk inhibitors are controlled such that Cdk activity oscillates once per cell cycle. Little is …
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Regulation of mitotic exit in Saccharomyces cerevisiae
… division requires the coordination of several mitotic processes, such as chromosome segregation, spindle disassembly, and cytokinesis. Progression into mitosis is driven by mitotic cyclin dependent kinase (CDKs) activity. In order for cells to exit from mitosis, mitotic CDKs must be …
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Mitotic Exit Control in Budding Yeast: Regulators and Dynamics
… Cdc14 is released from nucleolus to promote mitotic exit (ME). Cdc14 release and ME is controlled by mitotic cyclin-Cdk oscillation, the FEAR network including a non-proteolytic function of separase (Esp1), and the Mitotic Exit Network (MEN) indirectly activated by spindle elongation through …
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The Regulation of Autophagy and Its Role in Mitotic Exit
Autophagy is an evolutionarily conserved pathway in which cells enclose cytoplasmic contents in double membrane vesicles and deliver them to the lysosome for degradation. Autophagy plays critical regulatory roles in cancer, aging, neurodegeneration, immunity and many other physiological processes. …
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Identification of novel regulators of mitotic exit in Saccharomyces cerevisiae
… promoted by the activity of CDK complexed with mitotic cyclins. Upon faithful segregation of a full complement of DNA between each daughter cell, exit from mitosis proceeds. In order for cells to exit from mitosis and enter into G 1, mitotic CDKs must be inactivated. In Saccharomyces cerevisiae, …
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The Mitotic Exit Network detects spindle position and anaphase entry
The Mitotic Exit Network (MEN), an essential GTPase signal-transduction cascade, controls mitotic exit in budding yeast. The MEN protects genomic integrity by ensuring chromosome segregation is complete prior to cytokinesis. Two signals are required for MEN activation: (1) movement of the nucleus …
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Regulation and functions of Cdc14 in mitotic exit in Saccharomyces cerevisiae
… cell, the series of events that comprise the mitotic cell division cycle must be carefully regulated. Much of this regulation affects the transitions between the stages of the cell cycle, which are controlled by proteins known as cyclin dependent kinases (CDKs). High levels of CDKs promote …
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Regulation of the localization of Lte1, a S. cerevisiae mitotic exit activator
… Entry into mitosis is initiated by the action of mitotic cyclins complexed with the cyclin dependent kinase (CDK). Once the chromosomes have been successfully segregated, the exit from mitosis ensues. In order for cells to exit from mitosis, mitotic CDKs must be inactivated. The inactivation of …
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Spatial and temporal coordination of genome segregation with activation of the Mitotic Exit Network
… signal transduction cascade known as the Mitotic Exit Network (MEN) governs the final cell cycle transition, the mitosis to G1 transition. To ensure the accurate execution of mitosis, MEN activity is coordinated with other cellular events. The work presented in this thesis elucidates the …
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Regulation of the mitotic exit network components Tem1 and Cde 15 in Saccharomyces cerevisiae
… by cyclin dependent kinase activity (CDK). Mitotic cyclins associated with CDK promote the segregation of genetic material ensuring that each daughter receives a complete complement of the genome. In order for exit from mitosis into G1 to occur, mitotic CDK activity must be inactivated. In …
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Cell cycle regulation during gametogenesis in budding yeast
… during gametogenesis. First, I show that the mitotic exit network, which is a signaling pathway essential for mitotic exit, is dispensable for the meiotic divisions, and in fact signals via a mechanism distinct from mitosis. Second, I present data that the Polo kinase Cdc5, which activates …
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CHARACTERIZATION OF MITOTIC REGULATORS ACM1 AND CDC14
Mitotic exit and cytokinesis are driven by a complex set of processes that serve to
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Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
… An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial quality control during inheritance, and organelle inheritance checkpoints for …
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Mechanisms of regulation of the spindle position checkpoint kinase, Kin4
… is generally solved by the positioning of the mitotic spindle according to these spatial cues. Defects in spindle positioning can lead to the generation of cells with incorrect organelle, genetic and molecular contents, fate and/or, spatial orientation. Cells have evolved feedback mechanisms …
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INSIGHTS INTO SUBSTRATE RECOGNITION BY THE ANAPHASE PROMOTING COMPLEX (APC)
Mitotic exit depends on the proper degradation of numerous cell cycle-regulated proteins, which is executed by an E3 ubiquitin ligase called the anaphase promoting complex (APC). APC adds polyubiquitin chains to numerous substrates, which leads to their subsequent degradation in late mitosis and G1 …
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Regulation of the Intracellular Trafficking of Ajuba by Cell Density and Cell Cycle-Dependent Mechanisms
… signal (NES) in its preLIM domain guides its exit from the nucleus to the cytoplasm. The essential role of the NES signal was underlined by insights into Ajuba variant 1 and its response to Leptomycin B treatment. Specific GFP fusion experiments provided additional evidence for the active …
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Mitotic Dynamics of Normally and Mis-attached Chromosomes and Post-mitotic Behavior of Missegregated Chromosomes
… to the two daughter cells is the major task of mitotic cells. The segregation is controlled by a complex system in the cell and relies mainly on the interaction between microtubules (MTs) of the mitotic spindle and kinetochores (KTs), specialized protein structures that assemble on each …
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The regulation of chromosome segregation by Aurora kinase, protein phosphatase 1 and nucleolar protein UTp7
… through its effect on Cdc14. Furthermore, the mitotic exit block caused by Cdc14 inactivation is relieved partially by the simultaneous inactivation of Utp7. Thus, Utp7 is a multifunctional protein that plays essential roles in the vital cellular processes of ribosome biogenesis, chromosome …
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Regulation of Anaphase Promoting Complex Coactivators
… APC-Cdc20 activity, APC-Cdh1 degrades multiple mitotic proteins from mitotic exit through G1; inhibitory phosphorylation of Cdh1 by CDK and Polo kinase may allow accumulation of Cdh1 targets in the subsequent cell cycle. I demonstrate lethality of exact endogenous gene replacement of CDH1 with …
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