Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Mitotic Checkpoint Complex"”.
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Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores
… attachments, the spindle assembly checkpoint (SAC), activates the mitotic checkpoint complex (MCC), to inhibit the E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C). Inhibition of the APC/C then delays premature chromosome segregation by preventing APC/C-mediated …
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Mechanism of APC/C activation and substrate specificity in mitosis
… strictly controlled by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate …
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Molecular Mechanisms Involved in Chromosome Segregation
… and couples it to the microtubules (MTs) of the mitotic spindle. In human cells, the details of CCAN-CENP-ANuc assembly are unknown. This thesis investigates the structure and assembly of the human CCAN-CENP- ANuc complex, showing that CCAN tightly grips the linker DNA of the CENPANuc. CENP-C …
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Safeguard of Mitosis: The Spindle Checkpoint
… attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been implicated in cancers, birth defects, and other human diseases. In presence of kinetochores that are not attached or …
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Characterisation of the KA1 & KA2 domains and interaction with APC/C
… One important ligase is the anaphase promoting complex/cyclosome (APC/C) which is responsible for faithful segregation of chromosome during mitosis. Failure to regulate this process can lead to aneuploidy, one of the main causes of cancer. It is therefore important to understand the function and …
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TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
… cells are equipped with multiple defenses. Checkpoints can sense problems and halt a cell’s progression through the cell cycle in order to allow repairs. More drastically, cells can also prevent passing on mutations to progeny by triggering apoptosis, or programmed cell death. This work will …