Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 387 for “"Mitosis"”.
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Safeguard of Mitosis: The Spindle Checkpoint
In mitosis, the kinetochore-microtubule attachment is under surveillance by the spindle checkpoint to ensure the fidelity of chromosome segregation. Defects in the checkpoint could lead to aneuploidy, which has been implicated in cancers, birth defects, and other human diseases. In presence of …
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Characterizing the RanGAP1-RanBP2 complex in mitosis
Der RanGAP1-RanBP2 Komplex stellt ein faszinierendes makromolekulares Gebilde dar, welches mindestens zwei enzymatische Aktivitäten umfasst. Zum einen beinhaltet der Komplex die GTP-Hydrolyse aktivierende Funktion, die RanGAP1 zusammen mit RanBP2 ausübt, zum anderen besitzt RanBP2 zusammen mit Ubc9 …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
… now appears to play a key role in stimulus-mitosis coupling. The increased free calcium concentrations created by enhanced entry, impaired exit or mobilization of intracellular stores provides the link between extracellular mitogenic signals and the intracellular cell cycle regulatory …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
Quiescent thymocytes are stimulated to divide by a variety of compounds. These may be subdivided into four categories. The first group includes parathyroid hormone, vitamin D3 and its metabolites and raised extracellular calcium concentrations. Enhanced calcium influx provoked directly or possibly …
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Mechanisms underlying spatial control of exit from mitosis
During mitosis, cells must accurately segregate their genome in order to produce healthy daughter cells. In budding yeast, cells align their anaphase spindle along a predetermined axis of division in order to partition their genome into the daughter cells. In the event that the spindle becomes …
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The Influence of Cellular Redox State on Mitosis
… B, by changes in mitochondrial metabolism during mitosis. In early mitosis, an increase in mitochondrial membrane potential coincides with a robust reduction in cellular redox status, preventing disulfide bond-mediated activation of Aurora kinase B as a determinant of anaphase onset. In cells …
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Mechanism of APC/C activation and substrate specificity in mitosis
… the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate specificity are controlled by its interactions with two coactivators, Cdc20 and Cdh1. In contrast to Cdh1, APC/C activation by Cdc20 during mitosis …
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Kinetochore-derived Microtubules: from Molecular Regulation to their Role in Mitosis
… of KT–MT interaction in early stages of mitosis.
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Cellular tracking and mitosis detection in dense in-vitro cellular data
… emphasised the growing importance of cell mitosis, as this information can be directly used in the estimation of the cell cycle and in the understanding of complex biological mechanisms. Due to the increasing clinical interest in the automatic analysis of cellular data, a substantial number …
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Effects of prolonged mitosis on neural stem cells in vivo during development
… development. Yet, how perturbed neural stem cell mitosis kinetics affects cell fate following neural stem cell division is not well understood. Our lab recently discovered prolonging mitosis of mouse neural progenitors, either ex vivo or in vitro, alters fate decisions forcing early increased …
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Mathematical Imaging Tools in Cancer Research - From Mitosis Analysis to Sparse Regularisation
… drugs, since atypical duration and outcome of mitosis, the process of cell division, can be an indicator of successfully working drugs. As an imaging modality we focus on phase contrast microscopy, hence avoiding phototoxicity and influence on cell behaviour. As a drawback, the common halo- and …
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Genetic analysis of dynein function in the nervous system and in mitosis
… in interphase cells and plays multiple roles in mitosis. The importance of this motor is underlined by the fact that mutations in Dynein heavy chain, the motor-containing subunit of dynein, cause neurological disorders in humans. How dynein exerts its diverse roles in healthy cells, and how …
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Regulation of Progression through Unperturbed Mitosis and in the Presence of Environmental Stress
During mitosis, the replicated genome is distributed onto two daughter cells. Perfect regulation of progression through mitosis is essential for an error-free segregation and propagation of the genome. Surveillance pathways like the mitotic spindle checkpoint have evolved to prevent mitotic defects …
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Investigating the cellular toxicology of silver nanoparticles using a single-cell, mitosis-focused approach
… of this work was to develop and validate a new, mitosis-based, single-cell toxicity approach. This contributes to the current need of toxicology research to replace animal testing with predictive in vitro models. Cell division-based assays would be better at predicting risk than other commonly …
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Observations on division, nuclear-body-size relation and mitosis of the common marine Ameba ; Flabellula citata
Thesis (M.A.)--University of Kansas, Zoology, 1926.
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Analysis of the S. pombe sister chromatid cohesin subunit in response to DNA damage agents during mitosis.
… cell undergoes two alternative life cycles mitosis or meiosis, the first producing identical daughter cells of a diploid genetic content, and the second for genetic diversity and cells of a haploid genetic content. Studies in various experimental systems, from yeasts to humans, have …
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Effects of altered expression of the sumo conjugating enzyme, UBC9 on mitosis, meiosis and conjugation in Tetrahymena thermophila
… events such as transcription, DNA repair and mitosis. The segregation of the <em>Tetrahymena thermophila</em> genome into two different nuclear compartments provides an unusual context for the analysis of SUMOylation. Each cell contains a transcriptionally silent, diploid germ line …
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Morphological Remodeling of the Endoplasmic Reticulum During Mitosis and Its Influence on the Integrity of the Spindle Apparatus
… the contributions of the ER shaping proteins in mitosis. Through screening ER shaping protein depletions for mitotic failures, we find one, <em>ReepB</em>, that display division failures during cortical divisions. Additionally, <em>ReepB</em> disruption affects the ER coated structure when …
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