Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Mitogen-activated protein kinases (MAPK)"”.
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
The mitogen-activated protein kinases (MAPK) are a family of interrelated signal transduction kinases mediating intracellular responses to extracellular events. They are involved in mediating complex cellular events including, cell differentiation, cell proliferation, and cell death. Extracellular …
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UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
<p>Mitogen activated protein kinases (MAPK) p38 and ERK have both been reported to bind endothelial nitric oxide synthase (eNOS) with submicromolar affinity via proposed interactions with a pentabasic non-canonical MAPK binding sequence in the autoinhibitory insertion of eNOS. The neuronal isoform, …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… concentrations of GPCR agonists such as the mitogens LPA and S1P as well as therapeutically relevant concentrations of cannabinoids. Moreover, this study reveals ADAM17 and HB-EGF as the main effectors of this mechanism in most of the cancer cell lines investigated. However, depending on the …
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Strukturen der Kraftübertragung im quergestreiften Muskel : Protein-Protein-Wechselwirkungen und Regulationsmechanismen
… dramatisch ändert, was mit einer veränderten Proteinzusammensetzung einhergeht. Immunfluoreszenz-Analysen von Skelettmuskelzellen verschiedener Differenzierungsstadien implizieren, dass die Signalwege, welche die Dynamik der Fokalkontakte in Nichtmuskelzellen bestimmen, nur für frühe Stadien …
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Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA
… has thus far been on the oncogenic MCV early proteins, large tumour (LT) and small tumour (sT) antigens, there is a knowledge gap regarding MCV miRNA and its functional significance in MCV pathogenesis. Given the emerging importance of viral miRNAs in virus-host interaction and pathogenesis, …
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Sulfate -Reducing Bacteria and Their Contribution to Intestinal Epithelial Disorders
… cell cycle traverse after 4h. This H2S-induced mitogenic response was mediated by mitogen-activated protein kinases (MAPK) ERK and p38, as revealed by kinase inhibition studies. Microarray analysis using an Affymetrix Rat Array(TM) confirmed that exposure to H2S (90 min) caused acute hypoxia, as …
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Development of a novel co-culture based in vitro model system to study the wound healing process
… 1 mM OTC reduced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) at 21 days post-surgery suggesting potential anti-scarring mechanism. However, large animal to animal variation in the expression levels of collagen biosynthesis markers made it difficult to demonstrate any …
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Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei
… that can be modulated by small molecules. The mitogen-activated protein kinases (MAPK) pathway is a three-tiered signaling cascade that regulates cell responses to stimuli and are involved in essential processes. MAPKs can regulate differentiation, virulence, apoptosis, cell cycle and gene …
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The role of c-Jun N-terminal kinase one and two in motoneuron maturation and maintenance
… 1991; Oppenheim., 2005 ). Subgroups of the mitogen activated protein kinases (MAPK) family have been implicated in neuronal differentiation, death, regeneration, and survival (Bogoyevitch and Kobe, 2006; Frebel and Wiese, 2006). The c-Jun N-terminal kinases (JNKs) are stress-activated …
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Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
… (TJ) and the activation of cellular pathways, as mitogen-activated protein kinases (MAPK) and NLRP3 inflammasome, which are linked to chronic inflammatory diseases. The alteration of epithelial/endothelial barrier in Caco-2 and HUVEC monolayers, treated with LPS or HG alone or together with EVOO …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
… skin tumor growth. The mechanisms of EGFR’s mitogenic effects on keratinocytes were examined using EGFR null keratinocytes and an EGFR inhibitor. Genetic ablation or inhibition of EGFR decreased keratinocyte proliferation and resulted in epidermal hypoplasia. EGFR regulated keratinocyte …
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Investigation of the host-mediated proteolytic response to pulmonary Mycobacterium Avium Complex infection
… disease is driven by host-derived matrix metalloproteinases (MMPs). Unlike Mycobacterium tuberculosis (MTb) infection, the mechanisms of tissue destruction during MAC infection are not well-characterised. Here, I aim to elucidate if MMPs are upregulated during MAC infection, and how MMP …
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Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
… production of the Fragile X Mental Retardation Protein (FMRP) leads to changes in dendritic morphology and resultant cognitive and behavioral manifestations characteristic of individuals with FXS. FMRP is an RNA-binding protein that is believed to regulate the translation of a large number of …