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Showing 1 to 20 of 56 for “"Mitochondrion"”.
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Characterization of a Novel Fis1 Interactor Required for Peripheral Distribution of the Mitochondrion of Toxoplasma Gondii
Toxoplasma’s singular mitochondrion is extremely dynamic and undergoes morphological changes throughout the parasite’s life cycle. While intracellular‚ the mitochondrion is maintained in a lasso shape that stretches around the parasite periphery and is in close proximity to the pellicle‚ suggesting …
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Anoxia-Mediated Electrical Suppression in the Cerebral Cortex of the Western Painted Turtle (Chrysemys picta bellii): Role of the Mitochondrion
The vertebrate brain is one of the most oxygen-demanding organs of the body. In animals that are intolerant to severe hypoxia or anoxia, the brain undergoes irreparable harm within minutes of insufficient oxygen supply. The western painted turtle (Chrysemys picta bellii) has evolved the ability to …
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Metabolic downregulation during diapause in embryos of Artemia franciscana
… flux will lead to metabolic 'starvation' of the mitochondrion, and in turn will reduce mitochondrial oxidative phosphorylation during diapause. Measurements of ATP, ADP and AMP show that substantial decreases occur in ATP:ADP ratio and in adenylate energy charge during diapause. Respiration …
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Effects of carnitine on medium-chain fatty acid metabolism in newborn pigs
… because of their passive diffusion into the mitochondrion. However, upon feeding medium-chain triglycerides (MCT) to piglets (n = 16) followed by serial blood sampling, we observed significant changes in free and acyl-carnitines in plasma as determined using a newly developed HPLC procedure …
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… a host of outer membrane proteins, targeting a mitochondrion for autophagy. While most literature details a wholesale removal of all mitochondria from a cell, recent work describes a localized form of mitophagy that removes selective parts of the network. Mitochondria targeted by Parkin during …
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Structural studies of the mitochondrial ribosome and co-translational insertion of membrane proteins
The mitochondrion, a constituent of eukaryotic cells is important in the synthesis of ATP through a process called oxidative phosphorylation. The enzymes that make up the subunits of oxidative phosphorylation in humans and yeast are encoded by both nuclear DNA and in mitochondrial DNA. As such the …
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Estudio de los lncRNAs MDL1 y MDL1AS en diferentes tipos de tumores y su relevancia clínica en adenocarcinoma rectal
… and cell migration. In all these processes, the mitochondrion plays a fundamental role, since it is the organelle in charge of cell metabolism and also participates in communication with the nucleus, regulating different cellular functions. The processes occurring within the mitochondrion as well …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
The mitochondrion plays a vital role in the cellular energy (ATP) provision of the human pathogen Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To maintain the cellular energy provision, ATP has to …
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Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
… of long-chain fatty acid importation into the mitochondrion. In the heart, long-chain fatty acids are transported into the mitochondrion by the rate-limiting enzyme, carnitine palmitoyl transferase 1 (CPT1). CPT1 is potently inhibited by malonyl-CoA, the product of the acetylCoA carboxylation …
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Nuclear Encoded Proteins Important in Mitochondrial Genome Stability
The mitochondrion is widely known to be the site of cellular respiration and the factory of cellular energy. Similar to the nucleus, mitochondria house genetic material (mtDNA), which is responsible for the production of proteins essential to mechanisms required for cellular respiration. …
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Mechanism of Action Studies of Phenotypic Whole-cell Active Antimalarial Leads Through Target Identification
… amounts of KP68 were localized in the ER. The mitochondrion was, however, implicated in the action of KP68. Although colocalization was not observed between the MitoTracker Deep Red and KP68, significant amounts of the compound localize around the mitochondrion membrane. Finally, all compounds …
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Transcription Regulates Biased Mitochondrial DNA Inheritance
… import of nuclearly encoded proteins into the mitochondrion as well as supporting oxidative phosphorylation. Loss of mtDNA causes problems with maintaining membrane potential and mitochondrial ATP production, making mtDNA of critical importance to cells. However, mtDNA inheritance in …
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Lipoic acid protein ligases in Plasmodium spp.
… a plastid related organelle, and in the mitochondrion and thus two organelle specific lipoylation pathways are present in these parasites. Biosynthesis of the cofactor occurs in the apicoplast. Octanoyl-[acyl carrier protein]: protein N-octanoyltransferase (LipB) catalyses the attachment …
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The characterisation of family-13 kinesins in Trypanosoma brucei
… while the rest were found localised to the mitochondrion, cell body or flagellum. Attempts to probe the function of these kinesins using RNAi resulted in a reduction of cell growth in three of the six kinesins studied, but no gross changes in cellular morphology were observed. The distinct …
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Characterization and control of ketonic rancidity in the lauric acid oils.
… Evidence was presented to demonstrate that the mitochondrion was a site of antifungal activity. It was concluded that the conversion of fatty acids into methyl ketones was a detoxification mechanism for their removal from the environment.Extrinsic factors (temperature, pH, aw, preservatives and …
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Identification and functional characterization of the mitochondrial adenine nucleotide carriers of Trypanosoma brucei
… the counter exchange of ADP for ATP in the mitochondrion of all eukaryotes. In the genome of the kinetoplastid parasite Trypanosoma brucei, three putative ADP/ATP carrier sequences (MCP5, MCP15 and MCP16) and one GDP/GTP (MCP13) entries were analyzed by sequence analyses and phylogenetic …
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Analyzing the diet composition of Lake Trout (Salvelinus namaycush) in Upper Priest Lake
… located in the cytochrome oxidase 1 gene of the mitochondrion to identify said fragments. Out of a total of 61 samples 63.4% were identified as Lake Trout; 19.0% were identified as Pygmy Whitefish (Prosopium coulteri); 14.2% were identified as Kokanee Salmon (Onchohynchus nerka); and 1.5% were …
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Live cell proximity biotinylation enables proteomic analysis of mitochondria-endoplasmic reticulum contact sites
… subcompartments to understand how the mitochondrion communicates with the rest of the cell, and in particular, with the endoplasmic reticulum. These proteomes led to the identification of a protein that may be a component of a tethering complex between mitochondria and the endoplasmic …
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Analysis of the subcellular localization of proteins implicated in Alzheimer’s disease
… The MAM is highly enriched in PSEN1 and PSEN2. Mitochondrion-ER appositions are increased in Psen1⁻ʹ⁻/Psen2⁻ʹ⁻ mouse embryonic fibroblasts (MEFs) and also in familial AD (FAD) and sporadic AD (SAD) patient cells. These results, which were performed using mammalian cells, have not been studied in …
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