Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Mitochondrial turnover"”.
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
… adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function during atrophic conditions. Autophagy is a highly conserved proteolytic pathway responsible for the degradation of dysfunctional organelles and protein …
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The Role of Parkin-Mediated Mitophagy During Aging and Exercise in Skeletal Muscle
… ligase that is involved in mitophagy and the turnover of mitochondria. Parkin is extensively studied in neuronal tissue, but its role in skeletal muscle has not been fully explored. The overall purpose of this dissertation was to examine the effects of aging and exercise on Parkin-mediated …
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Axonal transport and life cycle of mitochondria in Parkinson's disease model
… Parkinson’s disease, has been implicated in mitochondrial dynamics and removal. However, it is not clear how Parkin plays a role in mitochondrial turnover in vivo, and whether the mature neurons possess a compartmentalized Parkin-dependent mitochondrial life cycle. Using the live …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
… elucidate the mechanisms by which IGF-1 promotes mitochondrial protection in cancer. Previously, we determined that the mitophagy receptor BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is induced by IGF-1 to support mitochondrial turnover and protection. Here, we analysed a …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells remains mostly unknown. Mitochondria are key organelles for energy production, and, therefore, cancer cells rely on mitochondrial maintenance to support rapid cell proliferation. In this thesis, the effects …
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Identification of components required for mitophagy and mitochondrial inheritance by genetic screens in yeast
… (ER) and mitochondria are important for the mitochondrial turnover by autophagy, also called mitophagy. Mitophagy is a process ensuring the appropriate quality and quantity of mitochondria by sequestering a mitochondrion within a double membrane and delivering it to degradative organelles. …
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Investigating the role of mitochondrial dysfunction in a Drosophila model of C9orf72 ALS/FTD
Mitochondrial dysfunction is a prevalent feature in many neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). ALS is a debilitating and incurable disease characterised by the loss of upper and lower motor neurons leading to symptoms such as …
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THE ORGANIZATION OF MITOCHONDRIAL QUALITY CONTROL AND LIFE CYCLE IN THE NERVOUS SYSTEM IN VIVO IN THE ABSENCE OF PINK1
Maintenance of healthy mitochondria is crucial in cells, such as neurons, with high