Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Mitochondrial transfer"”.
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Astrocytes Rescue Neuronal Health After Cisplatin Treatment Through Mitochondrial Transfer.
… health after cisplatin treatment through mitochondrial transfer.</p> <p>Author: Krystal English</p> <p>Advisory Professor: Dr. Cobi J. Heijnen, Ph.D.</p> <p>Chemotherapy-induced cognitive impairments are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used …
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Exogenous Mitochondrial Transfer and IL-6: Modulating Adipocyte Metabolism in Obesity-associated Dysregulation
… explores an innovative strategy for addressing mitochondrial dysfunction in obesity which is a critical aspect of this multifactorial problem. The research findings presented herein uncover the impact of introducing exogenous mitochondria into NIH3T3-L1 adipocytes on various aspects of adipocyte …
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Age-Related Hamster Mitochondrial Changes and Oocyte Changes Following Autologous Platelet Mitochondrial Microinjection
… study's objective was to verify age-related mitochondrial changes in oocytes from old hamsters compared with those from young hamsters. We used autologous platelet mitochondrial microinjection to improve the mitochondrial quality and quantity of aged oocytes to improve their pregnancy …
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From Protein Structure to Clinical Strategy: An In silico Investigation of Mitochondrial DNA Mutations in Type 2 Diabetes and Degenerative Disc Disease for Targeted Nutritional Interventions
… stress intersect. Increasing evidence identifies mitochondrial dysfunction as a shared mechanistic pathway underlying both metabolic and degenerative disease processes. Mitochondrial DNA (mtDNA), which encodes essential structural subunits of the electron transport chain (ETC) as well as critical …
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The molecular genetics of Type 2 diabetes
… mutations in the tRNA<sup>Leu(UUR)</sup> gene of mitochondrial DNA and in the glucagon receptor gene. <br></br><br></br> The Introductory chapter presents an overview of Type 2 diabetes, and the influence of the environment and the contribution of genetics to its development. It then introduces …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
… time, associated with significant attenuation of mitochondrial membrane potential in all three cell types, highlighting a generalised effect of HCA on cell biology. Functional mitochondria were required for the therapeutic potential of MSCs to enhance SAEC wound repair. Mitochondrial transfer from …