Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Mitochondrial respiratory chain"”.
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Pathological features of mitochondrial respiratory chain dysfunction
… These processes include ATP generation by the respiratory chain, aspartate synthesis by matrix aminotransferases, and long-chain fatty acid catabolism by the beta oxidation pathway. Given the role of mitochondria in maintaining cellular physiology, mitochondrial dysfunction often leads to …
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Inhibition of the Toxoplasma gondii replication by inhibition of the mitochondrial respiratory chain
… für diese Parasiten notwendig. Die mitochondriale Atmungskette von Toxoplasmen und Plasmodien weist eine Komponente auf, die in Säugerzellen nicht vorkommt und deshalb einen viel versprechenden Angriffspunkt für Antiparasitika darstellt: T. gondii und P. falciparum besitzen anstelle …
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Regulation of fatty acid and mitochondrial respiratory chain genes in a hypobaric hypoxia-induced right ventricular hypertrophy rat model
Includes bibliographical references.
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The Effects of Neuropathy-Inducing Organophasphate Esters om Chick Dorsal Root Gangli Cell Cultures
… alterations of ATP concentrations and changes in mitochondrial transmembrane potential (DYm) following exposure to neuropathy-inducing OP compounds, suggesting that mitochondrial dysfunction occurs. The present dissertation proposed an investigation using chick embryo DRG cultures to explore early …
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Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… MCT4 expression. Both combinations increased mitochondrial membrane permeability, correlating with increased cell death. Proteomic analysis of Met+Ven treated cells revealed decreased expression of core mitochondrial respiratory chain complex 1 protein (NDUFV1) and alterations in complex 4 …
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Exploring neurodegeneration in Ataxia-Telangiectasia
… Cancer predisposition, immunodeficiency and respiratory disease can result in premature death. The life expectancy of a patient with A-T is 30 years old. The phenotype is highly heterogeneous when partially functioning ATM protein and kinase are present. The exact mechanism for disease …
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Cardiac mitochondrial respiration in two rodent models of obesity
… diabetes, increased FFA supply decreases cardiac mitochondrial bioenergetic capacity. Furthermore, we also hypothesized that females possess innate cardioprotective programs that will result in enhanced bioenergetic capacity compared to males. We examined our hypothesis employing two rodent models …
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Modelling and investigating treatments of childhood inherited mitochondrial diseases in zebrafish.
Mitochondrial DNA depletion syndromes (MDDS) are a group of severe, individually rare, clinically heterogeneous disorders that primarily affect children. Affected tissues tend to be those with a high energy demand such as the central nervous system and skeletal muscle. MDDS stem from disruption to …
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The Effect of PDSS2, a Component of the Coenzyme Q Biosynthetic Pathway, on Murine Oocyte Embryo Development
… of coenzyme Q (coQ), a component of the mitochondrial respiratory chain, as it has been previously shown that both transcript and protein expression of various coQ biosynthetic enzymes decrease in aged murine oocytes. To further explore the impact of coQ deficiency on female fertility, we …
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Antioxidants in Normal and Epileptic Brain: Effect on Synaptic Plasticity, Neural Network Physiology, and Memory
… impairment. Oxidative stress and reduced mitochondrial respiratory chain complex I (MRCI) function has been found in human TLE and a mouse model of TLE. The Kv1.1 knockout (KO) mice, a preclinical model of TLE, display cognitive deficits and reduced hippocampal long-term potentiation. …
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Mitochondrial metabolism in cancer transformation and progression
… metabolic landscape. Of note, downregulation of mitochondrial genes is associated with the worst clinical outcome across all cancer types and correlates with the expression of epithelial-to-mesenchymal transition (EMT) gene signature, a feature of invasive and metastatic cancers. Consistently, …
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… (LS) is one of the most prevalent inherited mitochondrial disorders in pediatric population, typically presenting in early childhood with psychomotor regression and progressive neurological decline. Current understanding suggests that pathogenic variants affecting mitochondrial …
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Molecular Mechanisms Underlying Aerobic Respiration and Heme Regulation in Yeast
… expression and oxygen consumption. The levels of mitochondrial respiratory chain complex proteins were found to be increased in Δswi3 cells as compared to the parent cells. Deletion of SWI3 also induced the expression of aerobic respiration genes under high heme conditions. Computational analysis …
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IDENTIFICAZIONE DI UNA NUOVA CAUSA GENETICA IN UN CASO FAMILIARE DI ENCEFALOMIOPATIA MITOCONDRIALE E DEFICIT DI CITOCROMO C OSSIDASI.
… gene as the cause of an infantile progressive mitochondrial myopathy. The human GFER (growth factor ERV1 homolog), also called ALR (augmenter of liver regeneration), belongs to the ERV1/ALR sulfhydryl oxidase family, which requires flavin adenine dinucleotide (FAD) as a cofactor. The …
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Mechanism of Metformin Action in Dermal Fibroblasts
… hyperglycemia is dysregulated AMPK signaling and mitochondrial complex activity, which regulates both glucose uptake and cellular energy status. Current therapeutic methods to counter hyperglycemia include tight euglycemic control and/or intensive insulin treatment, which are associated with …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
… RTC-1 was found to inhibit complex I of the mitochondrial respiratory chain (NADH:ubiquinone oxidoreductase), leading to a likely increase in the AMP to ATP ratio and the consequential activation of the cellular energy regulator, AMPK. This in turn stimulated the signalling pathway which …
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Using molecular approaches to understand Complex I deficiency in mouse models
… a major electron entry point to the mitochondrial respiratory chain, couples electron transfer from NADH to ubiquinone to proton pumping across the mitochondrial inner membrane, and generates the proton motive force that drives ATP synthesis and transport processes. The ~1 MDa …
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A putative interaction between mitochondrial cytochrome c oxidase subunit II (COX II) to lamin A/C and LAP2α in colon epithelial cells.
… to Lamin A/C and LAP2 α. Cox2 is encoded by the mitochondrial genome and imported into complex IV (COX) of the mitochondrial respiratory chain (MRC). The majority of mitochondrial proteins are encoded by nuclear DNA. However, 13 essential subunits of the MRC are encoded by mtDNA. The MRC is …
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The role of RNA modifications in mitochondrial translation
Mitochondrial gene expression entails multiple steps, one of which is translation, performed by the mitochondrial ribosome. Post-transcriptional RNA nucleotide modifications have been identified in mitochondrial (mt)-rRNAs. However, little is known about their role in terms of mitochondrial …
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Identification and functional characterisation of different inner mitochondrial membrane supercomplexes
… is densely packed with proteins necessary for mitochondrial activity, including oxidative phosphorylation (OXPHOS) complexes and transporters. Mitochondrial respiratory chain (MRC) complexes, which generate ATP by OXPHOS, associate in higher-order assemblies, known as supercomplexes (SC), that …
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