Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Mitochondrial oxidative stress"”.
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Chemical probes for the study of mitochondrial oxidative stress
The implication of oxidative stress in ageing, and various disease states, has resulted in great interest in understanding the processes associated with it. Mitochondria are the major source of reactive oxygen species (ROS) via the electron transport chain. ROS may be free radicals, or molecules …
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Consequences of Endogenous Mitochondrial Oxidative Stress in the Heart
<p>For many years, it has been proposed that oxidative stress within the mitochondria causes mutations to the mitochondrial genome, resulting in changes in copy number per single cell. Ultimately, this compensatory increase in mtDNA, coupled with an increase in mutations, has been suggested to play …
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Overexpression of Amyloid Precursor Protein Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptosis Pathway
… co-expression of Bcl-2. APP caused depletion of mitochondrial GSH, induced opening of the permeability transition pore, and triggered cytochrome c release. Each of these events was inhibited by GSH but was unaffected by BOC indicating that they were oxidative stress-dependent and upstream of …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
… Previous studies have demonstrated that oxidative stress-associated genetic, metabolic and biological alterations contribute to CML cell survival and drug refractory. Mitochondria and NAD(P)H oxidase (NOX) are the major sources of BCR-ABL-induced cellular reactive oxygen species (ROS) …
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Role of oxidative stress in photoreceptor degeneration
… and represent the major cellular source of oxidative stress. ROS are capable of attacking molecules such as DNA, proteins and lipids, and of compromising either the structural and functional integrity or the survival of cells. Mitochondria also play a key role in apoptosis, the major …
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Neurodegeneration and behavior in rodents treated with chronic methamphetamine
… a monoamine oxidase (MAO)-dependent increase of mitochondrial oxidative stress in catecholaminergic substantia nigra pars compacta (SNc) dopamine and locus coeruleus (LC) norepinephrine axons. Moreover, it has been demonstrated that applying chronic meth treatment (28 days of 5mg/kg injections …
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Neuroprotective Effects of Anthocyanins on Neuronal Death Induced by Inhibition of Bcl-2 and Oxidative Stress
… pathophysiology underlying these diseases is mitochondrial oxidative stress (MOS) leading to neuronal death. Here, we investigated the neuroprotective effects of a novel class of nutraceuticals, anthocyanins, against MOS-induced death in primary cultures of rat cerebellar granule neurons …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… Cu/Zn superoxide dismutase (SOD1), resulting in mitochondrial oxidative stress and intrinsic apoptosis. Transgenic mice expressing a G93A mutant of SOD1 provide an in vivo model to investigate motor neuron death during disease progression. The principal regulators of intrinsic apoptosis are the …
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Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model
… responses to ER calcium perturbation, mitochondrial oxidative stress and subsequent cell death. Our results argue for unique and undiscovered regulatory effects of gingerol on the ER calcium circulation system, and suggest that the expression of STIM1 in these neurons protects against …
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The use of a genetic strategy to study the role of modulation of oxidative stress by uncoupling proteins 2 and 3 in the pathogenesis of Type 2 Diabetes
Mitochondrial dysfunction has been implicated in the early pathogenesis of Type 2 Diabetes. The uncoupling proteins 2 and 3 are mitochondrial proteins found in man that have been implicated in protecting mammals from the effects of over-nutrition. Examination of the effect of genetic variation in …
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Toward Quantitative Understanding of Compartmentalized NADPH Metabolism in Cancer Cells
… biosynthesis and protecting cells against oxidative stress. Over the past decades, extensive research has studied key NADPH regeneration pathways and investigated whether targeting these pathways constitutes an effective cancer therapy. However, fundamental questions still remain …
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The effect of acute alcohol exposure on hepatic oxidative stress and function: prevention by micronutrients
… of acute ethanol administration on hepatic oxidative damage and apoptosis was examined using both an in vivo and in vitro approach; the effect of micronutrient supplementation prior and during ethanol exposure was also studied. The following studies were performed: (1) ethanol administration …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… the senescence, recent studies have emphasized mitochondrial DNA hypothesis because mitochondria is the major ROS generator in addition to its high vulnerability to oxidative damage. Transforming growth factor β1 (TGF β1) has well been known to suppress epithelial cell growth and recently been …
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Investigating the role of mitochondrial dysfunction in a Drosophila model of C9orf72 ALS/FTD
Mitochondrial dysfunction is a prevalent feature in many neurodegenerative diseases including Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). ALS is a debilitating and incurable disease characterised by the loss of upper and lower motor neurons leading to symptoms such as …