Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Mitochondrial membranes"”.
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Mechanism Determination of the Effects of Pancratistatin on Model Mitochondrial Membranes
… a lipid composition meant to mimic the inner mitochondrial membranes (IMM). The IMM mimic was composed of three lipids: 1-palmitoyl-2-oleoyl-sn- glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), and tetraoleoyl cardiolipin (TOCL). Small-angle …
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Ion Transport Processes in Isolated Corn (Zea Mays L.) Mitochondria (Dibucaine, Methomyl, Phospholipids)
… phospholipid and fatty acid compositions of corn mitochondrial membranes were determined.
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Characterization of the Saccharomyces cerevisiae gene MGP1, a novel member of the ras gene superfamily that functions in the mitochondrial biogenesis
<p>This dissertation characterizes Mgp1p, a mitochondrial protein that functions in mitochondrial biogenesis. Mgp1p is the first protein related to the p21[superscript] H-ras oncoprotein shown to function in mitochondria;The Saccharomyces cerevisiae gene MGP1 was isolated based on its ability to …
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Hibernation is super complex: dynamics of electron transport system supercomplexes
… complexes form supercomplexes (SCs) within mitochondrial membranes, perhaps increasing respiratory capacity or reducing reactive oxygen species production. My project aimed to determine the abundance, composition, and stability of SCs in a hibernator. Hibernators have dynamic metabolisms …
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The Role of Fasting Acylcarnitines in Metabolic Flexibility from Short Term High Fat Feeding
… oxidation once fed, leading to a buildup of mitochondrial metabolites such as acylcarnitines. Carnitine, essential for fatty acyl-CoA transport through the inner and outer mitochondrial membranes, can be an indicator of mitochondrial distress as elevated levels tend to spill over into plasma …
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Mitochondrial Structure-Function in health and disease
Mitochondrial structure and function are inextricably linked ("structure-function"), with decrements in structure-function evident across diseases. Barriers to new therapies include a complete understanding of the underlying molecular culprits, as well as effective mitochondria-targeted therapies …
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Pharmacological aspects of the inhibition of mammalian respiratory complex I
Mitochondrial complex I, a large respiratory enzyme located in the inner mitochondrial membrane, catalyses electron transfer from NADH to ubiquinone while concomitantly translocating protons across the membrane to sustain ATP synthesis. A crucial aspect of the pharmacology of complex I is …
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The oxidative metabolism of malate plus pyruvate, and a-ketoglutarate by vitamin E-deficient rat liver mitochondria
… or beneficial effects of the vitamin on liver mitochondrial respiration from both groups. No significant effect of in vitro additions of vitamin E on liver mitochondrial respiration was found. Liver mitochondria from E-def rats generally had faster respiration rates than those from E-suff …
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Cardiolipin Regulates Mitophagy Through The Pkc Pathway
… (CL), the signature phospholipid of mitochondrial membranes, is important for cardiovascular health. Perturbation of CL metabolism is implicated in cardiovascular disease (CVD). The link between CL and CVD may be explained by the physiological roles of CL in pathways that are …
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Nano- and Micro-Second Electrical Pulsing of B16-F10 Mouse Melanoma Cells: Plasma Membrane and Sub-Cellular Organelle Changes
… study.</p> <p>Morphological changes on plasma membranes and cell organelles were analyzed with transmission electron microscopy (TEM) immediately after one to six applied pluses. TEM micrographs demonstrated morphological changes in plasma membrane and mitochondrial structure for treated cells …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
Mitochondrial network remodelling is crucial for cells to adapt and respond to metabolic cues and stress signals. Processes collectively known as mitochondrial dynamics, including ongoing cycles of fusion and fission, regulate mitochondrial shape, size and distribution, governing mitochondrial …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… Recently, the uncharacterised protein, mitochondrial fission regulator 1 like protein (MTFR1L), has been identified as a substrate for the metabolic kinase adenosine monophosphate kinase (AMPK). Phylogenetically, MTFR1L has been categorised within the mitochondrial fission regulator 1 …
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Morphological and histochemical observations of hepatic peroxisomes and lysosomes of rats after treatment with methylmercuric chloride, hydrogen peroxide and gamma radiation
… disruption of peroxisomal, lysosomal and mitochondrial membranes and formation of different shapes and sizes of peroxisomes at day 2. Damage appeared to be mild at day 7 and no apparent damage persisted until day 21. Following the whole body irradiation of 750 R, granularity in hepatic …
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The Role of Bax and Bak in Necrotic Cell Death
… in cells deficient for Cyclophilin D (CypD), a mitochondrial prolyl isomerase that resides in the matrix of the mitochondria. CypD is required for programmed necrosis because it regulates the mitochondrial permeability transition pore (MPTP). The MPTP is thought to span the intermembrane space …
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Non-toxic concentrations of α-synuclein exacerbate Parkinson's disease-like cell death by inducing mitochondrial dysfunction
… a decrease of total cellular energy levels. The mitochondrial toxin, 1-methyl-4-phenylpyridinium ion (MPP+), induced cell death in SHSY-5Y cells that was both concentration- and time-dependent. α-Syn (30 μM) significantly exacerbated MPP+-induced cell death in this model of PD. This suggests that …
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Some Studies on the Purification and the Properties of Monoamine Oxidase
Attempts were made to purify rat liver mitochondrial MAO in a single step by affinity chromatography. Except for tryptamine and serotonin-Sepharose, which irreversibly bound the enzyme, most adsorbents bound little if any of the enzyme. This was true for both detergent (triton X-100 and digitonin) …
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Effect of Quantum Dots, Novel Biological Imaging Agents, in Liver Cells in Vitro
… the effect on cell viability, ATP production, mitochondrial membrane potential and reactive oxygen species (ROS) production. The results showed no significant effect on cell viability, ATP production and ROS production. However, the mitochondrial membrane potential of cells was significantly …
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The Role Of Cardiolipin In Iron Homeostasis And Glutathione Metabolism
… (CL) is the signature phospholipid of mitochondrial membranes, where it is synthesized locally and plays a critical role in mitochondrial bioenergetic functions. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates …
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Host cell death in Legionella pneumophila pathogenesis and immunity
… (PE) and phosphatidylcholine (PC) on the mitochondrial membrane in a manner that appears to require host cofactor(s). The lipase activity is essential to its ability to activate caspase-3 via the production of free fatty acids and 2-lysophospholipids, which destabilize the mitochondrial …
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