Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Mitochondrial fusion"”.
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Regulation and roles of nutrient-dependent mitochondrial fusion
Mitochondria continuously alter their shape via fusion and fission and interestingly, this dynamic balance is critical for maintaining organelle function and cellular homeostasis. Studies have shown that mitochondria undergo fusion during amino acid starvation-induced autophagy. This mitochondrial …
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Role of trans-Golgi network vesicles in mitochondrial fusion
The continuous cycles of membrane fusion and fission are hallmarks of mitochondrial behaviour. In recent decades, the study of mitochondrial dynamics has come to the forefront of cell biology due to a growing recognition that the ever-changing shape of mitochondria has a basic impact on their …
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Anti-apoptotic MCL-1 Localizes to the Mitochondrial Matrix and Couples Mitochondrial Fusion to Respiration
… that different forms of MCL-1 reside in distinct mitochondrial locations and exhibit separable functions. On the outer mitochondrial membrane, a MCL-1 isoform acts like other anti-apoptotic BCL-2 molecules to antagonize apoptosis, whereas an amino-terminally truncated isoform of MCL-1 that is …
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The Mitochondrial Fusion Protein, Optic Atrophy 1 (OPA1), Alters Cellular Metabolism to Support Cancer Cell Viability
… TNBC is critically dependent upon alterations in mitochondrial-governed metabolism. To preserve homeostasis, mitochondria undergo an equilibrium of two counteracting remodelling processes: fission (division) and fusion (elongation). The inner mitochondrial membrane GTPase, OPA1, is a …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
… of mitochondria with higher levels of mitochondrial networking and they show significant changes in the proteins of mitochondrial dynamics. Observed changes in mitochondrial fusion and fission proteins including MFN1, MFN2, OPA1 and DNM1L suggest that activation of Wnt/β-catenin …
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Identification of cellular functions of cardiolipin as physiological modifiers of barth syndrome
… is an anionic phospholipid synthesized in the mitochondrial inner membrane. Perturbation of CL metabolism leads to Barth syndrome (BTHS), a life threatening genetic disorder. I utilized genetic, biochemical and cell biological approaches in yeast to elucidate the cellular functions of CL. …
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Nutrient and Stress-Induced Mitochondrial Hyperfusion Regulates Cell Death Pathways
… a precise balance of membrane fission and fusion to maintain mitochondrial genome integrity and levels of oxidative phosphorylation. Mitochondria have been shown to shift the balance of these two opposing pathways to drive a hyperfusion response following proteostasis stress conditions to …
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Autism Spectrum Disorder and Mitochondrial Dysfunction: The Role of Mitochondrial Dynamics
… disorder (ASD). Our research group reported that mitochondrial dysfunction was associated with ASD in South African children diagnosed with ASD using differential methylation and metabolomics studies. Propionyl-CoA Carboxylase Subunit Beta (PCCB) was differentially methylated in our cohort ASD …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
… to be critical for their functioning. Among the mitochondrial proteins that regulate their dynamism, OPA1 is the gatekeeper of mitochondrial fusion and thus modulates oxidative phosphorylation. AIM: The immunomodulatory role of mitochondria on the activity of antigen-presenting cells has been …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… High glucose also reduced the expression of the mitochondrial fusion regulatory protein, optic atrophy-1 (OPA1), with the inhibition of p38MAPK in high glucose attenuating this effect. Conclusion Hyperglycaemia induced pyknotic-like phenomenon, suppressed the proliferation, and reduced …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… previous work proved that this peptide induces mitochondrial fusion through Drp1 phosphorylation and prevented norepinephrine-elicited mitochondrial fission. In the present work, we aimed to elucidate the underlying mechanism by which angiotensin-(1-9) could prevent cardiomyocyte hypertrophy …
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Burn Serum Stimulates Mitochondrial Fission in C2C12 Myoblasts
… with a hypercatabolic status. Impairment of mitochondrial function has been observed in the muscle of burn patient's. OBJECTIVE: We hypothesize that muscle atrophy due to burn injur y is associated with an alteration in mitochondrial dynamics. This study was designed to investigate changes in …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… were collected and analyzed for the changes in mitochondrial DNA copy number and mitochondrial mass. We found that mitochondria mass gradually increased from G1 phase to mitotic phase and reduced back at the returning G1 phase. However, mtTFA, NRF-1, PRC, known as transcriptional factors …
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Mitofusin 2 Regulated Transport of Mitochondria is Necessary for Axonal Integrity
… has a previously defined role in facilitating mitochondrial fusion, we propose a direct role for MFN2 in mediating transport based on its interaction with key components of the mitochondrial transport apparatus and perturbation of transport in MFN2 null DRG neurons. MFN2 does not provide a …
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Mitochondrial Stress Signals Induce a Drug Tolerant Persister Phenotype in Triple Negative Breast Cancer Cell Models
… of interferon induction downstream of mitochondrial damage as a novel DTP mechanism. For this, different functional aspects of mitochondria were targeted in human (MDA-MB-231) and mouse (4T1) cell models of triple negative breast cancer including inhibition of ETC complex-1 using …
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Mitochondrial dysfunction in hereditary optic neuropathies
MITOCHONDRIAL DYSFUNCTION IN HEREDITARY OPTIC NEUROPATHIES Mitochondrial pathologies are a heterogeneous group of clinical manifestations characterized by oxidative phosphorylation impairment. At the beginning of their recognition mitochondrial pathologies were regarded as rare disorders but indeed …
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In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
Mitochondrial function is integral in the regulation of neurogenesis. Our research group previously reported differentially methylated genes and metabolomic evidence converging on mitochondrial dysfunction in a South African autism spectrum disorder (ASD) cohort. Thus, subtle mitochondrial …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
… elucidate the mechanisms by which IGF-1 promotes mitochondrial protection in cancer. Previously, we determined that the mitophagy receptor BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is induced by IGF-1 to support mitochondrial turnover and protection. Here, we analysed a …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
Mitochondrial network remodelling is crucial for cells to adapt and respond to metabolic cues and stress signals. Processes collectively known as mitochondrial dynamics, including ongoing cycles of fusion and fission, regulate mitochondrial shape, size and distribution, governing mitochondrial …
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Insights Into Mitochondrial Genetic and Morphologic Dynamics Gained by Stochastic Simulation
… involved are not completely understood. The mitochondrial genetic bottleneck has puzzled biologists for a long time. Approximate models of genetic bottleneck proposed in the literature do not accurately model underlying biology. Recent studies indicate mitochondrial morphology changes during …
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