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Showing 1 to 20 of 226 for “"Mitochondrial function"”.
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Effect of aflatoxin B{u2081} on mitochondrial function
… as protein sufficient animals. Both types of submitochondrial particles were found to be more sensitive to aflatoxin B₁ than the whole mitochondria. It was concluded that the inhibition was limited in whole mitochondria by the inner mitochondrial membrane; and in protein deficient mitochondria …
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The Effect of Alhagi maurorum Medik on Mitochondrial Function
Mitochondrial bioenergetics are crucial for the optimal activity of the cell and are emerging therapeutic targets for the treatment of several metabolic syndromes and cancer. Alhagi maurorum plant is traditionally used in several clinical conditions due to its potential anti-inflammatory, …
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Ankyrin Dependent Mitochondrial Function and Bioenergetics In The Heart
… has yet to be investigated. MAMs are crucial to mitochondrial function and metabolism and are signaling hubs implicated in various cardiac pathologies. Among several functions, these sites mediate the direct transfer of calcium from the ER/SR to the mitochondria to modulate ATP synthesis. Given …
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Mitochondrial function in atherosclerosis and vascular smooth muscle cells
Abstract Mitochondrial function in atherosclerosis and vascular smooth muscle cells Johannes Reinhold Atherosclerosis is the leading cause of death in the Western world. Although mitochondrial DNA (mtDNA) damage has been implicated in atherosclerosis, it is unclear whether the damage is sufficient …
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ELUCIDATING THE ROLE OF BCAT1 IN MITOCHONDRIAL FUNCTION AND NEURODEVELOPMENT
… established in cancer metabolism and immune cell function, the role of BCAT1 in neuronal development and mitochondrial function remains elusive. Further, while recent findings link alterations in BCAT1 activity to neurological disorders, few are well-studied in the context of the brain. The work …
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Developmental Regulation of Mitochondrial Function in Ovine Fetal Skeletal Muscle
… of carbohydrates, fats and amino acids. Mitochondrial function is influenced by the abundance and activity of the complexes comprising the electron transfer system (ETS) and the balance between mitochondrial fusion and fission. Any factors which affect the development of skeletal muscle, …
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Optical Analysis of Mitochondrial Function and Heterogeneity in Cultured Hippocampal Astrocytes
Diese Dissertation beschreibt die Untersuchung mitochondrialer Heterogenität in kultivierten Astrozyten des neonatalen Rattenhippocampus. Im Rahmen der Neurophysiologie und Pathologie erfuhren sowohl die Rolle von Astrozyten als auch jene zerebraler Mitochondrien während der vergangenen zwei …
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Effects of Resistance Training on aged Skeletal Muscle and Mitochondrial Function
… production of reactive oxygen species (ROS), and mitochondrial DNA (MtDNA) deletions and mutations. Muscle mass declines at a rate of 1-2% each year after the age of 50, leading to muscle weakness, functional impairments, loss of independence, and an increase in falls. Additional declines in …
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Energy metabolism in skeletal muscle: mechanistic insights into mitochondrial function and growth
… species. We showed that skeletal muscle mitochondrial abundance through mitochondrial DNA (mtDNA) and protein may not be sufficient to determine their functionality significance in muscle of livestock. Particularly, avian mitochondrial function is independent of absolute mtDNA and protein …
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Influence of Weight Loss on Metabolic and Mitochondrial Function in the Mature Horse
… alterations in glucose and lipid metabolism, mitochondrial capacity and oxidant status during weight loss have yet to be analyzed. Skeletal muscle contains subsarcolemmal (SSM) and interfibrillar (IFM) mitochondria, which respond differently to physiological stimuli, impacting tissue and whole …
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The interaction of diet and mitochondrial DNA on mitochondrial function and organismal fitness
The influence of diet on mitochondrial functions has been a longstanding question in evolutionary biology as well as human health and well-being. Discovering the interaction between diet and mitochondrial DNA (mtDNA) can facilitate a better understanding of organelle and organism evolution and may …
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Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells
… An impaired immunologic response, including dysfunctional peripheral blood immune cells has been described as part of the septic syndrome. Mitochondrial dysfunction has been suggested to be a contributing factor in the pathogenesis of these alterations and restoration of mitochondrial function …
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Mitochondrial Function as a Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas
… low potency herbal material to be challenging. Mitochondrial functional analysis presents a novel opportunity to address this deficiency. Liquorice (Glycyrrhiza glabra L., Fabaceae) was selected as an initial herb to profile due to its ubiquity in herbal medicine and commercial teas. Methods …
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Significance of DNA base excision repair in the maintenance of mitochondrial function in Saccharomyces cerevisiae /
… been linked to the development of respiratory dysfunction, apoptosis, and aging. Base excision repair (BER) is the major and the only certain repair pathway existing in mitochondria that is in responsible for removing and repairing various base modifications as well as abasic sites (AP sites). In …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… and transcriptome analyses indicated that Gcn5 functions in the HAT module of the SAGA complex to regulate mitochondrial function and respiratory growth by promoting the TCA cycle, the oxidative phosphorylation pathway, and also the antioxidant defence systems. Phenotypic analyses indicated that …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… deposition in the liver by altering hepatic mitochondrial function, we assessed how TMAO and PAA affect hepatocyte bioenergetics in cell models of liver steatosis. Proliferative and differentiated HepaRG cells were cultured under standard conditions, and steatosis was established by 48h …
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