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Showing 1 to 4 of 4 for “"Mitochondrial fission factor"”.
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The Roles of Midzone and Peripheral Mitochondrial Fission in Pulmonary Arterial Hypertension
Mitochondrial fission is vital for maintaining mitochondrial health, regulating cellular processes like proliferation and apoptosis. Disrupted fission is associated with development of cardiovascular diseases, including pulmonary arterial hypertension (PAH), ischemia-reperfusion injury, cardiac …
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The Role of FAM21 in the Regulation of Mitochondrial Dynamics
Mitochondrial network remodelling is crucial for cells to adapt and respond to metabolic cues and stress signals. Processes collectively known as mitochondrial dynamics, including ongoing cycles of fusion and fission, regulate mitochondrial shape, size and distribution, governing mitochondrial …
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Characterisation of new factors regulating mitochondrial dynamics and cellular metabolism
… behaviour depends on continuous cycles of fission or fusion, which is mediated by large GTPase enzymes, facilitating the remodelling of the network to adapt and answer to cellular needs. However, the underlying molecular details of these events have not been fully elucidated. Recently, the …
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Investigation of Drp1 inhibition as potential therapy in pesticide-based models of Parkinson's disease
… As both pesticides influence mitochondria, and mitochondrial dysfunction has been implicated in Parkinson’s disease, I investigated how modulation of the mitochondrial fission factor Drp1 influenced the pesticide-induced pathology. Exploration of rotenone in vivo recapitulated dopaminergic …